Projects per year
Personal profile
Biography
Our gut microbiome is vital for health and carries out many functions that we can’t ourselves. An imbalance in the microbiome is associated with multiple diseases. Dr O’Brien’s work aims at identifying the nature of gut microbiome imbalance in different disease states; attempts to determine whether the observed changes cause disease or are a consequence of the disease process; as well as understand ways in which we can restore the gut microbiome following perturbation. Dr O’Brien has a particular interest in the inflammatory bowel diseases, and uses in vitro co-culture of bacteria and macrophages, combined with molecular genetic techniques, to increase our mechanistic understanding of host-bacteria interactions in these diseases.
Claire was awarded her PhD by the ANU Medical School in 2012 for her work investigating the role of microbes in the Inflammatory Bowel Diseases. Following her PhD, she was awarded an Australian Academy of Science France-Australia Science Innovation Collaboration Early Career Fellowship, and an NHMRC Peter Doherty Biomedical Research Fellowship. Previously, she was a Lecturer at the ANU Medical School and Senior Lecturer at the University of Wollongong. Claire joined UC in July 2020, and is Group Leader of the Host-Microbe Interactions group.
Education/Academic qualification
PhD, Microbiological aspects of Crohn's disease, Australian National University
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Collaborations and top research areas from the last five years
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Increasing Myogenesis and Reducing Inflammatory Pathways to Attenuate Sarcopenia in Crohn’s Disease – The ‘GUTSY’ project.
Etxebarria, N., Pyne, D., Beard, N., O'Brien, C., Pumpa, K. & Subramaniam, K.
31/01/22 → 31/12/23
Project: Research
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Microbial community stability dynamics to environmental triggers
Hold, G., Gordon, D. & O'Brien, C.
1/01/21 → 31/12/23
Project: Research
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AMR: Antimicrobial resistance in bacteria isolated from retail meat
20/01/21 → 19/12/21
Project: Research
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Comparative genomics and phenotypic studies to determine site-specificity of Escherichia coli in the lower gastrointestinal tract of humans
Barua, R., Pavli, P., Gordon, D. M. & O'Brien, C. L., 22 Jun 2023, In: Gut Microbes. 15, 1, p. 1-19 19 p., 2223332.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
A narrative review of the role of gastrointestinal dysbiosis in the pathogenesis of polycystic ovary syndrome
Parker, J., O'Brien, C. & Hawrelak, J., Jan 2022, In: Obstetrics & gynecology science. 65, 1, p. 14-28 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)18 Downloads (Pure) -
Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
Parker, J., O’brien, C., Hawrelak, J. & Gersh, F. L., 1 Feb 2022, In: International Journal of Environmental Research and Public Health. 19, 3, p. 1-25 1336.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)35 Downloads (Pure) -
Prevalence, diversity and genetic structure of Escherichia coli isolates from septic tanks
Behruznia, M., O'Brien, C. L. & Gordon, D. M., Feb 2022, In: Environmental Microbiology Reports. 14, 1, p. 138-146 9 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Review article: the future of microbiome-based therapeutics
Gulliver, E. L., Young, R. B., Chonwerawong, M., D'Adamo, G. L., Thomason, T., Widdop, J. T., Rutten, E. L., Rossetto Marcelino, V., Bryant, R. V., Costello, S. P., O'Brien, C. L., Hold, G. L., Giles, E. M. & Forster, S. C., 24 May 2022, In: Alimentary Pharmacology and Therapeutics. 56, 2, p. 192-208 17 p.Research output: Contribution to journal › Review article › peer-review
Open Access9 Citations (Scopus)
Activities
- 1 Invited talk
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Australian Academy of Science Food for Thought seminar series
Claire O'Brien (Speaker)
8 Jun 2021Activity: Talk or presentation › Invited talk