Projects per year
Personal profile
Biography
Our gut microbiome is vital for health and carries out many functions that we can’t ourselves. An imbalance in the microbiome is associated with multiple diseases. Dr O’Brien’s work aims at identifying the nature of gut microbiome imbalance in different disease states; attempts to determine whether the observed changes cause disease or are a consequence of the disease process; as well as understand ways in which we can restore the gut microbiome following perturbation. Dr O’Brien has a particular interest in the inflammatory bowel diseases, and uses in vitro co-culture of bacteria and macrophages, combined with molecular genetic techniques, to increase our mechanistic understanding of host-bacteria interactions in these diseases.
Claire was awarded her PhD by the ANU Medical School in 2012 for her work investigating the role of microbes in the Inflammatory Bowel Diseases. Following her PhD, she was awarded an Australian Academy of Science France-Australia Science Innovation Collaboration Early Career Fellowship, and an NHMRC Peter Doherty Biomedical Research Fellowship. Previously, she was a Lecturer at the ANU Medical School and Senior Lecturer at the University of Wollongong. Claire joined UC in July 2020, and is Group Leader of the Host-Microbe Interactions group.
Education/Academic qualification
PhD, Microbiological aspects of Crohn's disease, Australian National University
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Projects
- 4 Finished
-
CRISPR/Cas9 knockout of Escherichia coli genes found to be associated with Crohn’s disease patients using comparative whole genome sequencing
O'BRIEN, C. (CI)
1/09/23 → 31/08/24
Project: Research
-
Increasing Myogenesis and Reducing Inflammatory Pathways to Attenuate Sarcopenia in Crohn’s Disease – The ‘GUTSY’ project.
ETXEBARRIA, N. (CI), PYNE, D. (CoI), BEARD, N. (CoI), O'BRIEN, C. (CoI), PUMPA, K. (CoI) & Subramaniam, K. (CoI)
31/01/22 → 31/08/24
Project: Research
-
AMR: Antimicrobial resistance in bacteria isolated from retail meat
O'BRIEN, C. (CI)
20/01/21 → 19/12/21
Project: Research
-
Microbial community stability dynamics to environmental triggers
Hold, G. (CoI), Gordon, D. (CoI) & O'BRIEN, C. (CI)
1/01/21 → 31/12/23
Project: Research
-
The Relationship Between CSF1R Signaling, Monocyte-Macrophage Differentiation, and Susceptibility to Inflammatory Bowel Disease
Hume, D. A., M. Summers, K., O'BRIEN, C. & Pavli, P., 2025, In: CMGH Cellular and Molecular Gastroenterology and Hepatology. 19, 8, p. 1-27 27 p., 101510.Research output: Contribution to journal › Review article › peer-review
1 Citation (Scopus) -
Transcriptomic signatures of host immune responses in aphthous ulcers, the earliest lesions of Crohn's disease, suggest that bacterial uptake, rather than global dysbiosis, is the initiating factor
Whiley, P. J., Dixit, O. V., Das Gupta, M., Patel, H., Zhao, G., Connor, S. J., Summers, K. M., Hume, D. A., Pavli, P. & O'Brien, C. L., May 2025, In: Immunology and Cell Biology. p. 1-12 12 p.Research output: Contribution to journal › Article › peer-review
-
Diversity of antimicrobial-resistant bacteria isolated from Australian chicken and pork meat
Dixit, O. V. A., Behruznia, M., Preuss, A. L. & O'Brien, C. L., Feb 2024, In: Frontiers in Microbiology. 15, p. 1-15 15 p., 1347597.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Downloads (Pure) -
Prevention of pregnancy complications should be a priority
O'BRIEN, C., 1 Jun 2024, MJA Insight, p. 1-6 6 p.Research output: Contribution to Newspaper/Magazine/Bulletin › Article
-
Reducing the Risk of Pre-Eclampsia in Women with Polycystic Ovary Syndrome Using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies
Parker, J., O'Brien, C., Yeoh, C., L. Gersh, F. & Brennecke, S., Mar 2024, In: Journal of Clinical Medicine. 13, 6, p. 1-31 31 p., 1774.Research output: Contribution to journal › Review article › peer-review
Open AccessFile8 Citations (Scopus)
Activities
- 2 Invited talk
-
The gut microbiota: what do we know?
O'Brien, C. (Speaker)
8 Jun 2021Activity: Talk or presentation › Invited talk
-
Australian Academy of Science Food for Thought seminar series
O'Brien, C. (Speaker)
8 Jun 2021Activity: Talk or presentation › Invited talk