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Human rhinovirus (HRV) is a small RNA virus that causes the majority of common cold episodes and contributes significantly to viral-induced asthma exacerbations. It is therefore important to understand the molecular mechanisms behind HRV infection, in order to identify pathways that could be targeted for treatment, particularly with regards to high-risk patients such as those with asthma. The HRV genome encodes a number of different proteins, including two proteases that function to disrupt normal processes in infected cells, making it difficult for infected cells to respond to the virus.  Since the activity of these proteases contributes to the cellular damage observed during severe infection and is vital to the replication of HRV, our research aims to identify cellular pathways that are altered by HRV proteases. We use a variety of molecular virology techniques to study the effects of viral proteases and altered viruses on host cells, as well as examining the differences between asthmatic and non-asthmatic lung tissues.

Research Area

Biomedical discovery for disease prevention and treatment.

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Projects 2012 2014

Research Output 2006 2017

Scabies—An ancient itch that is still rampant today

THOMAS, J., Christenson, J., WALKER, E., Baby, K. & Peterson, G. M. 2017 In : Journal of Clinical Pharmacy and Therapeutics. p. 1-7 7 p.

Research output: Contribution to journalComment/debate

3 Citations

Rhinovirus 16 2A protease affects nuclear localization of 3CD during infection

WALKER, E., CROFT, S., Wei, K., Jans, D., Fulcher, A. J. & GHILDYAL, R. 2016 In : Journal of Virology. 90, 24, p. 11032-11042 11 p.

Research output: Contribution to journalArticle

Open Access
Human rhinovirus
Enterovirus
proteinases
infection
cytoplasm

A protocol to express and isolate HRV16 3C protease for use in protease assays

WALKER, E. & GHILDYAL, R. 2015 Rhinoviruses: Methods and Protocols. Jans, D. A. & Ghildyal, R. (eds.). USA: Humana Press, p. 143-148 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations

Nucleocytoplasmic transport of nucleocapsid proteins of enveloped RNA viruses

WALKER, E., GAHAN, M. & GHILDYAL, R. 2015 In : Frontiers in Microbiology. 6, JUN, p. 1-10 10 p.

Research output: Contribution to journalArticle

Protease of human rhinovirus: role in infection

WALKER, E., Jans, D. & GHILDYAL, R. 2015 Rhinoviruses: Methods and Protocols. Jans, D. A. & Ghildyal, R. (eds.). USA: Humana Press, p. 129-141 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter