Nicole BEARD

Available to supervise Higher Degree by Research students

20022019
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Personal profile

Biography

Dr Beard and her research team investigate how intracellular calcium signaling pathways initiate muscle contraction. We explore and define the mechanisms which lead to control of calcium signalling and the way in which these are disrupted in skeletal myopathies, cardiomyopathy and heart failure.

Muscle contraction occurs due to a cascade of events and relies on calcium release from intracellular stores. The four main cogs in the intracellular calcium signalling pathway are the calcium binding protein calsequestrin (CSQ), the ryanodine receptor (RyR) calcium release channel, and two linking proteins - triadin and junctin - which bind CSQ to the RyR. Control of calcium release in muscle is vital; disturbances in the process can lead to potentially fatal skeletal and cardiac conditions.

Despite their essential role in skeletal muscle and the heart, the functional and structural interactions between the proteins that drive calcium signalling are poorly understood and form the broad aims of our research.

Currently funded projects include:

  • Calcium signalling by intracellular calcium stores: implications for muscle performance and athletic ability
  • Calcium homeostatis disturbances and human heart failure
  • Understanding how chemotherapy agents cause cardiotoxicity

Research interests

  • Heart failure
  • Cardiomyopathy
  • Skeletal muscle ageing and myopathy

 

Related Links

External positions

Secretary, Gage Conferences on Musclee

20112020

Fingerprint Dive into the research topics where Nicole BEARD is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

Ryanodine Receptor Calcium Release Channel Medicine & Life Sciences
Calsequestrin Medicine & Life Sciences
Skeletal Muscle Medicine & Life Sciences
Sarcoplasmic Reticulum Medicine & Life Sciences
Muscle Chemical Compounds
Muscular Diseases Medicine & Life Sciences
Excitation Contraction Coupling Medicine & Life Sciences
Calcium Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2011 2015

Anthracyclines disrupt Ca2+ signalling in cardiomyocytes: a contribution to cardiac toxicity

BEARD, N., Dulhunty, A. F., Arnolda, L. & Blackburn, A.

1/01/1231/12/15

Project: OtherResearch

Research Output 2002 2019

2 Citations (Scopus)

Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814

Walweel, K., Gomez-Hurtado, N., Rebbeck, R. T., Oo, Y. W., Beard, N. A., Molenaar, P., dos Remedios, C., van Helden, D. F., Cornea, R. L., Knollmann, B. C. & Laver, D. R., 1 May 2019, In : Journal of Molecular and Cellular Cardiology. 130, p. 96-106 11 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Calmodulin
Phosphorylation
Calcium-Calmodulin-Dependent Protein Kinases

Characterising the effect of heat strain and exercise intensity on gut permeability in well-trained male runners

WALLETT, A., ETXEBARRIA, N., BEARD, N., PERIARD, J., SAUNDERS, P., MCKUNE, A. & PYNE, D., Nov 2018.

Research output: Contribution to conference (non-published works)Abstract

Permeability
Hot Temperature
Exercise
Lipopolysaccharides
Heart Rate
2 Citations (Scopus)
Ryanodine Receptor Calcium Release Channel
Post Translational Protein Processing
Muscle
Myocardium
Skeletal Muscle
3 Citations (Scopus)

Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding

Richardson, S. J., Steele, G. A., Gallant, E. M., Lam, A., Schwartz, C. E., Board, P. G., Casarotto, M. G., Beard, N. A. & Dulhunty, A. F., 1 Jan 2017, In : Journal of Cell Science. 130, 20, p. 3588-3600 13 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Ryanodine Receptor Calcium Release Channel
Protein Binding
Channelopathies
Tacrolimus
2 Citations (Scopus)

Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels

Walweel, K., Gomez-Hurtado, N., Oo, Y. W., Beard, N. A., dos Remedios, C., Johnson, C. N., Chazin, W. J., van Helden, D. F., Knollmann, B. C. & Laver, D. R., 4 Jul 2017, In : Journal of the American College of Cardiology. 70, 1, p. 115-117 3 p.

Research output: Contribution to journalLetter