Available to supervise Higher Degree by Research students

20022017
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Personal profile

Biography

Dr Beard and her research team investigate how intracellular calcium signaling pathways initiate muscle contraction. We explore and define the mechanisms which lead to control of calcium signalling and the way in which these are disrupted in skeletal myopathies, cardiomyopathy and heart failure.

Muscle contraction occurs due to a cascade of events and relies on calcium release from intracellular stores. The four main cogs in the intracellular calcium signalling pathway are the calcium binding protein calsequestrin (CSQ), the ryanodine receptor (RyR) calcium release channel, and two linking proteins - triadin and junctin - which bind CSQ to the RyR. Control of calcium release in muscle is vital; disturbances in the process can lead to potentially fatal skeletal and cardiac conditions.

Despite their essential role in skeletal muscle and the heart, the functional and structural interactions between the proteins that drive calcium signalling are poorly understood and form the broad aims of our research.

Currently funded projects include:

  • Calcium signalling by intracellular calcium stores: implications for muscle performance and athletic ability
  • Calcium homeostatis disturbances and human heart failure
  • Understanding how chemotherapy agents cause cardiotoxicity

Research interests

  • Heart failure
  • Cardiomyopathy
  • Skeletal muscle ageing and myopathy

 

Related Links

External positions

Secretary, Gage Conferences on Musclee

20112020

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Ryanodine Receptor Calcium Release Channel Medicine & Life Sciences
Calsequestrin Medicine & Life Sciences
Skeletal Muscle Medicine & Life Sciences
Sarcoplasmic Reticulum Medicine & Life Sciences
Muscle Chemical Compounds
Muscular Diseases Medicine & Life Sciences
Calcium Medicine & Life Sciences
Excitation Contraction Coupling Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2011 2015

Anthracyclines disrupt Ca2+ signalling in cardiomyocytes: a contribution to cardiac toxicity

BEARD, N., Dulhunty, A. F., Arnolda, L. & Blackburn, A.

1/01/1231/12/15

Project: OtherResearch

Research Output 2002 2017

Association of FK506 binding proteins with RyR channels - effect of CLIC2 binding on sub-conductance opening and FKBP binding

Richardson, S. J., Steele, G. A., Gallant, E. M., Lam, A., Schwartz, C. E., Board, P. G., Casarotto, M. G., Beard, N. A. & Dulhunty, A. F. 1 Jan 2017 In : Journal of Cell Science. 130, 20, p. 3588-3600 13 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Ryanodine Receptor Calcium Release Channel
Protein Binding
Channelopathies
Tacrolimus
1 Citations

Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels

Walweel, K., Gomez-Hurtado, N., Oo, Y. W., Beard, N. A., dos Remedios, C., Johnson, C. N., Chazin, W. J., van Helden, D. F., Knollmann, B. C. & Laver, D. R. 4 Jul 2017 In : Journal of the American College of Cardiology. 70, 1, p. 115-117 3 p.

Research output: Contribution to journalLetter

8 Citations

Core skeletal muscle ryanodine receptor calcium release complex

Casarotto, M., Wei-LaPierre, L. & BEARD, N. 2017 In : Clinical and Experimental Pharmacology and Physiology. 44, 1, p. 3-12 10 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Excitation Contraction Coupling
Skeletal Muscle
Sarcoplasmic Reticulum
Proteins

Physiology and Pharmacology of Ryanodine Receptor Calcium Release Channels

Dulhunty, A. F., Board, P. G., Beard, N. A. & Casarotto, M. G. 2017 In : Advances in Pharmacology. 79, p. 287-324 38 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Pharmacology
Muscular Diseases
Ion Channels
Tacrolimus Binding Proteins
3 Citations

Ryanodine receptor modification and regulation by intracellular Ca2 + and Mg2 + in healthy and failing human hearts

Walweel, K., Molenaar, P., Imtiaz, M., dos Remedios, C., van Helden, D., laver, D. & BEARD, N. 2017 In : Journal of Molecular and Cellular Cardiology. 104, p. 53-62 10 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
Sulfhydryl Compounds
Homeostasis
Heart Failure
Proteins