Nicole Beard

Accepting PhD Students

20022020

Research output per year

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Personal profile

Biography

Dr Beard and her research team investigate how intracellular calcium signaling pathways initiate muscle contraction. We explore and define the mechanisms which lead to control of calcium signalling and the way in which these are disrupted in skeletal myopathies, cardiomyopathy and heart failure.

Muscle contraction occurs due to a cascade of events and relies on calcium release from intracellular stores. The four main cogs in the intracellular calcium signalling pathway are the calcium binding protein calsequestrin (CSQ), the ryanodine receptor (RyR) calcium release channel, and two linking proteins - triadin and junctin - which bind CSQ to the RyR. Control of calcium release in muscle is vital; disturbances in the process can lead to potentially fatal skeletal and cardiac conditions.

Despite their essential role in skeletal muscle and the heart, the functional and structural interactions between the proteins that drive calcium signalling are poorly understood and form the broad aims of our research.

Currently funded projects include:

  • Calcium signalling by intracellular calcium stores: implications for muscle performance and athletic ability
  • Calcium homeostatis disturbances and human heart failure
  • Understanding how chemotherapy agents cause cardiotoxicity

Research interests

  • Heart failure
  • Cardiomyopathy
  • Skeletal muscle ageing and myopathy

 

Related Links

External positions

Secretary, Gage Conferences on Musclee

20112020

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Projects

Research Output

Running at Increasing Intensities in the Heat Induces Transient Gut Perturbations

Wallett, A., Etxebarria, N., Beard, N., Saunders, P., Welvaert, M., Periard, J., Mckune, A. & Pyne, D., 7 Aug 2020, (Accepted/In press) In : International Journal of Sports Physiology and Performance. p. 1-8 8 p.

Research output: Contribution to journalArticle

  • Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814

    Walweel, K., Gomez-Hurtado, N., Rebbeck, R. T., Oo, Y. W., Beard, N. A., Molenaar, P., dos Remedios, C., van Helden, D. F., Cornea, R. L., Knollmann, B. C. & Laver, D. R., 1 May 2019, In : Journal of Molecular and Cellular Cardiology. 130, p. 96-106 11 p.

    Research output: Contribution to journalArticle

  • 4 Citations (Scopus)

    Interventions for the long-term prevention of hereditary angioedema attacks

    BEARD, N., FRESE, M., Mere, P., Katelaris, C. & MILLS, K., 19 Aug 2019, In : Cochrane Database of Systematic Reviews. 2019, 8, p. 1-12 12 p., CD013403.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 1 Citation (Scopus)

    Interventions for the treatment of acute hereditary angioedema attacks

    FRESE, M., BEARD, N., Mere, P., Katelaris, C. & MILLS, K., 2019, In : Cochrane Database of Systematic Reviews. 2019, 8, p. 1-14 14 p., CD013402.

    Research output: Contribution to journalArticle

  • 1 Citation (Scopus)