Projects per year
Personal profile
Biography
Reena Ghildyal is currently Research Leader of the Biomedical Research Cluster within Faculty of Science and Technology. The research focus of the Cluster is to understand the basic mechanistic drivers of chronic inflammatory disease in order to develop novel therapeutics. Previous positions held by Reena include Head of School, Science and Deputy Director Health Research Institute.
Reena obtained her PhD in Life Science from Jawaharlal Nehru University, New Delhi, India; a premier Indian research university. This was followed by postdoctoral fellowships at the State Department of Agriculture, and Macfarlane Burnet Institute in Melbourne, Australia.
In 2004 Reena was invited to establish a respiratory virology research group as part of a new Chinese Government initiative within Fudan University, Shanghai. On her return to Australia in 2007, she has continued her association with Fudan University and has been instrumental in establishing several bilateral research collaborations between Chinese and Australian scientists.
Reena moved to University of Canberra in 2010 where she is currently Professor in Microbiology and Director, Centre for Research in Therapeutic Solutions.
The focus of Reena's research is molecular pathogenesis of respiratory viruses with special reference to asthma exacerbations. Current projects include the validation of respiratory syncytial virus (RSV) vaccine candidates in vitro and in vivo; elucidating the role of cytoskeleton in RSV assembly, investigating the role of rhinovirus (HRV) proteases in disease.
Reena collaborates with research groups within Australia (Monash University, University of Queensland) and Internationally (University of South Florida, University of Georgia, Imperial College, Fudan University) and her research is funded by National Health and Medical Research Council, Australia-China Science Research Fund and Australia-India Science and Technology Research Fund.
Research interests
- Molecular pathogenesis of respiratory viruses
- Molecular basis of asthma
- Respiratory virus assembly
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Preclinical assessment of Diferulylmethane-2, an Anti- RSV Therapeutic (PreDART)
Ghildyal, R., Looi, K., Kicic, A., Stick, S. & Larcombe, A.
29/06/22 → 1/01/24
Project: Research
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Mode of action of a drug targeting the polymerase on RSV M protein function
1/03/18 → 1/01/19
Project: Other
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Natural Exportin 1(XPO1) inhibitors as antiviral agents against Respiratory Syncytial Virus (RSV)
Ghildyal, R. & Mathew, C.
3/10/16 → 27/09/19
Project: Other
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KPT-335 as novel therapeutic for respiratory syncytial virus-via Univeristy of Georgia
24/07/15 → 30/06/17
Project: Other
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Ayurvedic formulations: potential COVID-19 therapeutics?
Mahaboob Ali, A. A., Bugarcic, A., Naumovski, N. & Ghildyal, R., Aug 2022, In: Phytomedicine Plus : International journal of phytotherapy and phytopharmacology. 2, 3, p. 1-14 14 p., 100286.Research output: Contribution to journal › Review article › peer-review
Open AccessFile2 Citations (Scopus)51 Downloads (Pure) -
Nuclear Transport of Respiratory Syncytial Virus Matrix Protein Is Regulated by Dual Phosphorylation Sites
Ghildyal, R., Teng, M. N., Tran, K. C., Mills, J., Casarotto, M. G., Bardin, P. G. & Jans, D. A., 19 Jul 2022, In: International Journal of Molecular Sciences. 23, 14, p. 1-13 13 p., 7976.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Downloads (Pure) -
Animal Models for the Study of Hepatitis B Virus Pathobiology and Immunity: Past, Present, and Future
Zhang, X., Wang, X., Wu, M., Ghildyal, R. & Yuan, Z., 16 Jul 2021, In: Frontiers in Microbiology. 12, p. 1-10 10 p., 715450.Research output: Contribution to journal › Review article › peer-review
Open AccessFile8 Citations (Scopus)10 Downloads (Pure) -
Lauric acid ameliorates lipopolysaccharide (LPS)-induced liver inflammation by mediating TLR4/MyD88 pathway in Sprague Dawley (SD) rats
Khan, H. U., Aamir, K., Jusuf, P. R., Sethi, G., Sisinthy, S. P., Ghildyal, R. & Arya, A., 15 Jan 2021, In: Life Sciences. 265, p. 1-17 17 p., 118750.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Respiratory Syncytial Virus Matrix Protein-Chromatin Association Is Key to Transcriptional Inhibition in Infected Cells
Li, H-M., Ghildyal, R., Hu, M., Tran, K. C., Starrs, L. M., Mills, J., Teng, M. N. & Jans, D. A., 18 Oct 2021, In: Cells. 10, 10, p. 1-21 21 p., 2786.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)6 Downloads (Pure)