Reena Ghildyal

Accepting PhD Students

1990 …2019
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Personal profile

Biography

Reena Ghildyal obtained her PhD in Life Science from Jawaharlal Nehru University, New Delhi, India; a premier Indian research university. This was followed by postdoctoral fellowships at the State Department of Agriculture, and Macfarlane Burnet Institute in Melbourne, Australia. 

In 2004 Reena was invited to establish a respiratory virology research group as part of a new Chinese Government initiative within Fudan University, Shanghai. On her return to Australia in 2007, she has continued her association with Fudan University and has been instrumental in establishing several bilateral research collaborations between Chinese and Australian scientists.

Reena moved to University of Canberra in 2010 where she is currently Professor in Microbiology and Director, Centre for Research in Therapeutic Solutions.

The focus of Reena's research is molecular pathogenesis of respiratory viruses with special reference to asthma exacerbations. Current projects include the validation of respiratory syncytial virus (RSV) vaccine candidates in vitro and in vivo; elucidating the role of cytoskeleton in RSV assembly, investigating the role of rhinovirus (HRV) proteases in disease.

Reena collaborates with research groups within Australia (Monash University, University of Queensland) and Internationally (University of South Florida, University of Georgia, Imperial College, Fudan University) and her research is funded by National Health and Medical Research Council, Australia-China Science Research Fund and Australia-India Science and Technology Research Fund.

Research interests

  • Molecular pathogenesis of respiratory viruses
  • Molecular basis of asthma
  • Respiratory virus assembly

Fingerprint Dive into the research topics where Reena Ghildyal is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

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Respiratory Syncytial Viruses Medicine & Life Sciences
Rhinovirus Medicine & Life Sciences
Cell Nucleus Active Transport Medicine & Life Sciences
Proteins Medicine & Life Sciences
Viruses Medicine & Life Sciences
Virus Assembly Medicine & Life Sciences
RNA Viruses Medicine & Life Sciences
Peptide Hydrolases Medicine & Life Sciences

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Projects 2009 2019

Research Output 1990 2019

1 Downloads (Pure)
Open Access
File
Unfolded Protein Response
Endoplasmic Reticulum Stress
Obesity
Inflammation
Cardiovascular Diseases
1 Downloads (Pure)

Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production

Hu, M., Schulze, K. E., Ghildyal, R., Henstridge, D. C., Kolanowski, J. L., New, E. J., Hong, Y., Hsu, A. C., Hansbro, P. M., Wark, P. A., Bogoyevitch, M. A. & Jans, D. A., 27 Jun 2019, In : eLife. 8, p. 1-30 30 p., 42448.

Research output: Contribution to journalArticle

Open Access
File
Respiratory Syncytial Viruses
Viruses
Dyneins
Mitochondrial Membrane Potential
Microtubules

Verdinexor (KPT-335), a Selective Inhibitor of Nuclear Export, Reduces Respiratory Syncytial Virus Replication In Vitro

Jorquera, P. A., Mathew, C., Pickens, J., Williams, C., Luczo, J. M., Tamir, S., Ghildyal, R. & Tripp, R. A., 1 Feb 2019, In : Journal of Virology. 93, 4, p. 1-17 17 p., e0168418.

Research output: Contribution to journalArticle

Open Access
Respiratory Syncytial Viruses
Cell Nucleus Active Transport
Virus Replication
virus replication
viruses
3 Citations (Scopus)
4 Downloads (Pure)

Human Rhinovirus 3C protease cleaves RIPK1, concurrent with caspase 8 activation

Croft, S. N., Walker, E. J. & Ghildyal, R., 1 Dec 2018, In : Scientific Reports. 8, 1, 11 p., 1569.

Research output: Contribution to journalArticle

Open Access
File
Receptor-Interacting Protein Serine-Threonine Kinases
Caspase 8
Rhinovirus
Protein Kinases
Apoptosis
6 Citations (Scopus)
1 Downloads (Pure)

Molecular changes during TGFβ-mediated lung fibroblast-myofibroblast differentiation: implication for glucocorticoid resistance

Breton, J-D., Heydet, D., Starrs, L., Veldre, T. & Ghildyal, R., Apr 2018, In : Physiological Reports. 6, 7, 12 p., e13669.

Research output: Contribution to journalArticle

Open Access
File
Myofibroblasts
Glucocorticoid Receptors
Airway Remodeling
Fibroblasts
Lung