Regan ASHBY

Former affiliation
20032019
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Personal profile

Biography

Regan graduated with his PhD in Medical Science from the Australian National University in 2007, under the supervision of Professor Ian Morgan. After completing his PhD, Regan received a two year Early Career Postdoctoral Fellowship from the University of Tuebingen, Germany, as part of the European Union, Marie-Curie European Training Program, with Dr Marita Feldkaemper and Professor Frank Schaeffel. On returning to Australia, Regan took up a lecturing position at the University of Canberra in 2011 before accepting the position of Assistant Professor within the Faculty in 2012. He now heads the Visual Neuroscience Group within the Centre for Research into Therapeutic Solutions (Health Research Institute). 

Regan's research focuses on the molecular pathways underlying the regulation of normal ocular growth, and how such neural pathways are affected during the development of the visual disorder myopia (short-sightedness). Myopia is now at epidemic proportion in many parts of the world, most notably in urban East Asia, where 80-90% of school-leavers are myopic. Recently, Regan’s research has shown that exposure to bright light levels; similar to that experienced by being outdoors, can prevent the development of experimental myopia in animal models. This protection appears to be driven by light-induced increases in the release of the neurotransmitter dopamine within the eye. This work has culminated in Regan being awarded the prestigious Attempto Prize for Neuroscience, from the University of Tuebingen, Germany (2010), and the Carl Zeiss Young Investigators Award in Vision Science (2013).  

Regan's current research looks at better understanding the genomic and epigenomic regulatory mechanisms by which exposure to high light levels can retard the development of myopia. 

Research interests

  • Investigating the underlying causes of the visual disorder myopia (short-sightedness)
  • Genomic/epigenomic regulation of ocular growth
  • Retinal neural development

External positions

Visiting Fellow, Australian National University

1 Feb 2012 → …

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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Projects 2016 2019

Research Output 2003 2018

16 Citations

The epidemics of myopia: Aetiology and prevention

Morgan, I. G., French, A. N., Ashby, R. S., Guo, X., Ding, X., He, M. & Rose, K. A. Jan 2018 In : Progress in Retinal and Eye Research. 62, p. 1-16 16 p.

Research output: Contribution to journalReview article

Myopia
Causality
Young Adult
Degenerative Myopia
Pressure
3 Citations

Bright light blocks the development of form deprivation myopia in mice, acting on D1 dopamine receptors

Morgan, I. G. & Ashby, R. S. 1 Apr 2017 In : Investigative Ophthalmology and Visual Science. 58, 4, p. 2317 1 p.

Research output: Contribution to journalComment/debate

Dopamine D1 Receptors
Myopia
Light
Retina
Dopamine
4 Citations

Contrasting Sex-and Caste-Dependent piRNA Profiles in the Transposon Depleted Haplodiploid Honeybee Apis mellifera

Wang, W., Ashby, R., Ying, H., Maleszka, R. & Forêt, S. 1 Jun 2017 In : Genome Biology and Evolution. 9, 5, p. 1341-1356 16 p.

Research output: Contribution to journalArticle

Open Access
File
caste
honeybee
Bees
methylation
Apis mellifera
1 Citations

Developmental and loco-like effects of a swainsonine-induced inhibition of a-mannosidase in the honey bee, apis mellifera

Wedd, L., ASHBY, R., Foret, S. & Maleszka, R. 2017 In : PeerJ. 2017, 3, p. 1-22 22 p.

Research output: Contribution to journalArticle

Open Access
File
Swainsonine
Mannosidases
mannosidases
swainsonine
Honey
6 Citations

Animal studies and the mechanism of Myopia - Protection by light?

Ashby, R. 1 Sep 2016 In : Optometry and Vision Science. 93, 9, p. 1052-1054 3 p.

Research output: Contribution to journalReview article

Myopia
Light
Neurotransmitter Agents
Epidemiologic Studies
Dopamine