Projects per year
Personal profile
Biography
Regan graduated with his PhD in Medical Science from the Australian National University in 2007, under the supervision of Professor Ian Morgan. After completing his PhD, Regan received a two year Early Career Postdoctoral Fellowship from the University of Tuebingen, Germany, as part of the European Union, Marie-Curie European Training Program, with Dr Marita Feldkaemper and Professor Frank Schaeffel. On returning to Australia, Regan took up a lecturing position at the University of Canberra in 2011 before accepting the position of Assistant Professor within the Faculty in 2012. He now heads the Visual Neuroscience Group within the Centre for Research into Therapeutic Solutions (Health Research Institute).
Regan's research focuses on the molecular pathways underlying the regulation of normal ocular growth, and how such neural pathways are affected during the development of the visual disorder myopia (short-sightedness). Myopia is now at epidemic proportion in many parts of the world, most notably in urban East Asia, where 80-90% of school-leavers are myopic. Recently, Regan’s research has shown that exposure to bright light levels; similar to that experienced by being outdoors, can prevent the development of experimental myopia in animal models. This protection appears to be driven by light-induced increases in the release of the neurotransmitter dopamine within the eye. This work has culminated in Regan being awarded the prestigious Attempto Prize for Neuroscience, from the University of Tuebingen, Germany (2010), and the Carl Zeiss Young Investigators Award in Vision Science (2013).
Regan's current research looks at better understanding the genomic and epigenomic regulatory mechanisms by which exposure to high light levels can retard the development of myopia.
Research interests
- Investigating the underlying causes of the visual disorder myopia (short-sightedness)
- Genomic/epigenomic regulation of ocular growth
- Retinal neural development
External positions
Visiting Fellow, Australian National University
1 Feb 2012 → …
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Collaborations and top research areas from the last five years
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Novel therapeutic agent: Dopamine treatment of Myopia (DTOM)
Chia, A. (CoI), Sim, B. (CoI), Foo, L. (CoI), Ashby, R. (CI) & THOMSON, K. (CoI)
9/10/23 → 8/10/26
Project: Research
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Refinement of a novel biomarker assay for myopia screening
THOMSON, K. (CI), KAROUTA, C. (CoI) & Ashby, R. (CoI)
16/06/23 → 6/09/24
Project: Research
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Commercialization of a novel treatment for myopia – generation of pharmacokinetic data for Phase II clinical trials
Ashby, R. (CI)
1/11/21 → 1/08/24
Project: Research
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Temporal integration of visual signals by the retina
Kang, P. (CoI) & Ashby, R. (CI)
17/06/21 → 31/03/22
Project: Research
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Improving chalkbrood disease protection in honey bee colonies using probiotics and prebiotics
NAYUDU, M. (CI), FRESE, M. (CoI) & ASHBY, R. (CoI)
1/09/20 → 19/04/23
Project: Research
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Retinal Function in Young Adults Following Topical Application of Levodopa to the Eye
Sabeti, F., Thomson, K., Maddess, T., Karouta, C., Leung, M., Anstice, N., Jong, T. & Ashby, R., 1 Oct 2024, In: Translational Vision Science and Technology. 13, 10, p. 1-16 16 p., 12.Research output: Contribution to journal › Article › peer-review
Open Access -
Rhinovirus protease cleavage of nucleoporins: perspective on implications for airway remodeling
Moorhouse, J., Val, N., Shahriari, S., Nelson, M., Ashby, R. & Ghildyal, R., 2023, In: Frontiers in Microbiology. 14, p. 1-7 7 p., 1321531.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Downloads (Pure) -
The role of the serotonergic system in atropine's anti-myopic effects
Thomson, K., Karouta, C., Weber, D., Hoffmann, N., Morgan, I. G., Kelly, T. & Ashby, R., 22 Sept 2023, (E-pub ahead of print) In: Biomedicine and Pharmacotherapy. 167, p. 1-13 13 p., 115542.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)38 Downloads (Pure) -
Correlation between small-scale methylation changes and gene expression during the development of myopia
Thomson, K., Game, J., Karouta, C., Morgan, I. G. & Ashby, R., Jan 2022, In: FASEB Journal. 36, 1, p. 1-25 25 p., e22129.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)96 Downloads (Pure) -
The safety and tolerability of levodopa eye drops for the treatment of ocular disorders: A randomized first-in-human study
Thomson, K., Karouta, C., Sabeti, F., Anstice, N., Leung, M., Jong, T., Maddess, T., Morgan, I. G., Game, J. & Ashby, R., Nov 2022, In: Clinical and Translational Science. 15, 11, p. 2673-2684 12 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus)