Projects per year
Personal profile
Biography
Regan graduated with his PhD in Medical Science from the Australian National University in 2007, under the supervision of Professor Ian Morgan. After completing his PhD, Regan received a two year Early Career Postdoctoral Fellowship from the University of Tuebingen, Germany, as part of the European Union, Marie-Curie European Training Program, with Dr Marita Feldkaemper and Professor Frank Schaeffel. On returning to Australia, Regan took up a lecturing position at the University of Canberra in 2011 before accepting the position of Assistant Professor within the Faculty in 2012. He now heads the Visual Neuroscience Group within the Centre for Research into Therapeutic Solutions (Health Research Institute).
Regan's research focuses on the molecular pathways underlying the regulation of normal ocular growth, and how such neural pathways are affected during the development of the visual disorder myopia (short-sightedness). Myopia is now at epidemic proportion in many parts of the world, most notably in urban East Asia, where 80-90% of school-leavers are myopic. Recently, Regan’s research has shown that exposure to bright light levels; similar to that experienced by being outdoors, can prevent the development of experimental myopia in animal models. This protection appears to be driven by light-induced increases in the release of the neurotransmitter dopamine within the eye. This work has culminated in Regan being awarded the prestigious Attempto Prize for Neuroscience, from the University of Tuebingen, Germany (2010), and the Carl Zeiss Young Investigators Award in Vision Science (2013).
Regan's current research looks at better understanding the genomic and epigenomic regulatory mechanisms by which exposure to high light levels can retard the development of myopia.
Research interests
- Investigating the underlying causes of the visual disorder myopia (short-sightedness)
- Genomic/epigenomic regulation of ocular growth
- Retinal neural development
External positions
Visiting Fellow, Australian National University
1 Feb 2012 → …
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Collaborations and top research areas from the last five years
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RLRL Project: Efficacy of once daily Repeated Low-level Red Light (RLRL) therapy compared to twice daily standard therapy in high myopes: A Non-Inferiority Trial
KAPHLE, D. (CI), ASHBY, R. (CoI), HARTONO, S. (CoI), Rose, L. (CoI), Schulz, A. (CoI), Deen, N. (CoI), Fakih, Z. (CoI), Chakraborty, R. (CoI) & Schmid, K. (CoI)
19/06/26 → 30/06/28
Project: Research
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Novel therapeutic agent: Dopamine treatment of Myopia (DTOM)
Chia, A. (CoI), Sim, B. (CoI), Foo, L. (CoI), ASHBY, R. (CI) & THOMSON, K. (CoI)
9/10/23 → 31/12/28
Project: Research
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The analysis of ocular samples in the chicken myopia model
ASHBY, R. (CI) & Schmid, K. (CoI)
1/03/17 → 30/06/28
Project: Other
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Refinement of a novel biomarker assay for myopia screening
THOMSON, K. (CI), KAROUTA, C. (CoI) & Ashby, R. (CoI)
16/06/23 → 6/09/24
Project: Research
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Commercialization of a novel treatment for myopia – generation of pharmacokinetic data for Phase II clinical trials
Ashby, R. (CI)
1/11/21 → 1/08/24
Project: Research
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Contribution of the serotonergic system to myopia and the therapeutic effects of atropine and pirenzepine
Thomson, K., Karouta, C. & Ashby, R., 1 Jan 2026, In: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 194, p. 118922 1 p., 118922.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
IMI: The Role of Light in Refractive Development and Myopia: Evidence from Animal and Human Studies: The Role of Light in Refractive Development and Myopia: Evidence from Animal and Human Studies
Ashby, R., Harb, E. N., Ostrin, L. A., Flitcroft, D. I., Schaeffel, F., Karouta, C., Gawne, T., Chakraborty, R., Thomson, K., Read, S., Baraas, R. C., Najjar, R. P., Rose, K., Phillips, J. R., Wu, P. C., He, X., Liu, X. N., Lan, W., Swiatczak, B. & Torii, H. & 2 others, , Dec 2025, In: Investigative Ophthalmology and Visual Science. 66, 15, p. 1-32 32 p., 5.Research output: Contribution to journal › Review article › peer-review
Open AccessFile14 Link opens in a new tab Citations (Scopus) -
Light Inhibits Lens-Induced Myopia through an Intensity-Dependent Dopaminergic Mechanism
Karouta, C., Thomson, K., Morgan, I. G. & Ashby, R., 2025, In: Ophthalmology Science. 5, 5, p. 100779 100779.Research output: Contribution to journal › Article › peer-review
Open Access14 Link opens in a new tab Citations (Scopus) -
Methylphenidate Inhibits the Development of Myopia by Altering Dopamine and Norepinephrine Reuptake
Karouta, C., Thomson, K., Morgan, I., Booth, L. & Ashby, R., Sept 2025, In: Investigative Ophthalmology and Visual Science. 66, 12, p. 1-20 20 p., 52.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Link opens in a new tab Citations (Scopus) -
Administration of Nicotine Can Inhibit Myopic Growth in Animal Models
Thomson, K., Karouta, C. & Ashby, R., 3 Sept 2024, In: Investigative ophthalmology & visual science. 65, 11, p. 1-17 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Link opens in a new tab Citations (Scopus)72 Downloads (Pure)
Press/Media
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Studies Conducted at University of Canberra on Myopia Recently Reported (Methylphenidate Inhibits the Development of Myopia by Altering Dopamine and Norepinephrine Reuptake)
ASHBY, R., KAROUTA, C. & THOMSON, K.
7/10/25
1 item of Media coverage
Press/Media: Expert Comment
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University of Canberra Researchers Yield New Study Findings on Ophthalmology (Light Inhibits Lens-Induced Myopia through an Intensity-Dependent Dopaminergic Mechanism)
ASHBY, R., KAROUTA, C. & THOMSON, K.
9/09/25
1 item of Media coverage
Press/Media: Expert Comment
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32nd Hong Kong International Optical Fair Opens Today
6/11/24
1 item of Media coverage
Press/Media: Expert Comment
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32nd Hong Kong International Optical Fair Opens Today Showcasing the Latest Eyewear Technology and Design Trends
6/11/24
1 item of Media coverage
Press/Media: Expert Comment
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Reuters 32nd Hong Kong International Optical Fair Opens Today
6/11/24
11 items of Media coverage
Press/Media: Expert Comment