Projects per year
Xiaonan Zhang is the Associate Professor in the Faculty of Science and Technology, University of Canberra. He now heads the Hepatitis B Virus (HBV) Group within the Centre for Research into Therapeutic Solution. His group focuses on clinic-oriented molecular biology and translational medicine of Hepatitis B Virus.
Xiaonan received his PhD degree from Fudan University, Shanghai, China, in 2012 and then worked at Shanghai Public Health Clinical Centre till 2021. In the past decade, his research has been dedicated to viral infections of public health importance, and particularly the molecular underpinnings of divergent outcomes of viral infections. His long-term focus on HBV has yielded unique insights that changed some key perceptions on the virus, one of which led to the discovery of a novel viral particle (Capsid-Antibody-Complexes, CACs) that has a substantial role in HBV pathogenesis. In addition, he also made significant contribution in emerging viral infections such as enterovirus 71 (hand foot and mouth disease), H7N9 Influenza virus, and COVID-19. After the initial identification of H7N9 influenza in human (2013), he and his colleagues soon unravelled the rapid emergence of oseltamivir resistance in patients with unfavourable outcomes. In 2020, during the first wave of the COVID-19 pandemic, he led a team of scientists from six institutions and performed a comprehensive analysis of SARS-CoV-2 infected patients in Shanghai. The unique dataset offered a first glimpse into the viral and host factors related to the clinical outcome of the disease.
Xiaonan moved to University of Canberra in 2021 where he continued to pursue his translational research on Hepatitis B virus. He collaborates with research groups within Australia (Peter Doherty Institute, University of Queensland) and internationally (Fudan University, National University of Singapore, University of Duisburg-Essen).
- Molecular pathogenesis of Hepatitis B Virus infection
- Development of therapeutic vaccine for chronic hepatitis B
- Next-generation sequencing and its application in viral infections
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
- 1 Similar Profiles
Dive into details
Select a country/territory to view shared publications and projects
- 3 Active
8/07/22 → 30/06/23
1/04/22 → 11/09/23
Performance of the pre-diagnostic pilot ELISA assay for capsid-antibody-complex in HBV mono-infection and HIV/HBV co-infection.
22/11/21 → 28/02/23
Zheng, Y., Xu, M., Zeng, D., Tong, H., Shi, Y., Feng, Y. & Zhang, X., Dec 2022, In: Diagnostic Pathology. 17, 1, 11.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile4 Downloads (Pure)
Zhang, X., Li, J., Hu, Y., Kozlowski, M., & 2 others, 4 Apr 2022, In: Journal of Experimental Medicine. 219, 4, p. 1-18 18 p., e20211838.
Research output: Contribution to journal › Article › peer-review
The role of hepatitis B virus surface proteins in regulating the maturation and secretion of complete and incomplete virionsXu, M., Li, C., Ding, J., Wu, M., Tang, Y., Yuan, Z. & Zhang, X., 2022, In: Journal of General Virology. 103, 4, p. 1-12 12 p., 001733.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile
Animal Models for the Study of Hepatitis B Virus Pathobiology and Immunity: Past, Present, and FutureZhang, X., Wang, X., Wu, M., Ghildyal, R. & Yuan, Z., 16 Jul 2021, In: Frontiers in Microbiology. 12, p. 1-10 10 p., 715450.
Research output: Contribution to journal › Review article › peer-reviewOpen AccessFile
Jia, X., Hu, L., Wu, M., Ling, Y., Wang, W., Lu, H., Yuan, Z., Yi, Z. & Zhang, X., Dec 2021, In: Scientific Reports. 11, 1, p. 4405 4405.
Research output: Contribution to journal › Short Survey/Scientific Report › peer-reviewOpen AccessFile