Research output per year
Research output per year
- 1 - 50 out of 75 results
Search results
-
2025
Potential role of liver-resident CD3+ macrophages in HBV clearance in a mouse hepatitis B model
Wang, C., Zai, W., Zhao, K., Li, Y., Shi, B., Wu, M., Zhou, X., Kozlowski, M., Zhang, X., Fang, Z. & Yuan, Z., Apr 2025, In: JHEP Reports. 7, 4, p. 1-15 15 p., 101323.Research output: Contribution to journal › Article › peer-review
Open Access -
2024
A Chromogenic In Situ Hybridization (CISH) Assay for Detection of HBV RNA, DNA, and cccDNA in Liver Tissue
Zhang, X., Lu, W., Feng, Y., Zhang, Z. & Yuan, Z., 2024, Hepatitis B Virus: Methods and Protocols. Guo, H. & Cuconati, A. (eds.). 2 ed. Netherlands: Springer, Vol. 2837. p. 137-148 12 p. (Methods in molecular biology (Clifton, N.J.)).Research output: A Conference proceeding or a Chapter in Book › Chapter › peer-review
-
A Fluorescent In Situ Hybridization (FISH) Assay for Detection of HBV RNA, DNA, and cccDNA in Cell Culture
Zhang, X., Yue, L., Li, C. & Yuan, Z., 2024, Hepatitis B Virus: Methods and Protocols. Guo, H. & Cuconati, A. (eds.). 2 ed. Springer, Vol. 2837. p. 125-135 11 p. (Methods in molecular biology (Clifton, N.J.)).Research output: A Conference proceeding or a Chapter in Book › Chapter › peer-review
-
Circulating capsid-antibody-complexes (CACs) drive intrahepatic complement deposition and inform subclinical liver inflammation in chronic hepatitis B
Tang, Y., Xu, M., Wang, C., Wu, M., Hu, L., Li, J., Lu, W., Zheng, Y., Zhang, M., Jiang, X., Zhu, C., Audsley, J., Tangkijvanich, P., Avihingsanon, A., Song, S., Liu, S., Lewin, S. R., George, J., Douglas, M. & Ling, Y. & 4 others, , Nov 2024, In: Antiviral Research. 231, p. 1-13 13 p., 106017.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Editorial: Viral interactions with the nucleus, volume II
Ciccarese, F., Zhang, X., Shahriari, S. & Ghildyal, R., 2024, In: Frontiers in Microbiology. 15, p. 1-2 2 p., 1419921.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Empirical assessment of the enrichment-based metagenomic methods in identifying diverse respiratory pathogens
Jia, X., Wang, W., Wu, M., Pang, L., Yang, C., Ling, Y., Yi, Z. & Zhang, X., Dec 2024, In: Scientific Reports. 14, 1, p. 1-11 11 p., 24493.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Modulation of monocyte activity by hepatocellular MicroRNA delivery through HBsAg particles: Implications for pathobiology of chronic hepatitis B
Li, J., Ma, X., Xuan, Q., Li, Q., Wu, M., Shi, B., Fang, Z., Chen, L., Chen, J., Wen, Y., Zhu, C., Zhu, L., Zhang, X. & Yuan, Z., Jun 2024, In: Hepatology. p. 1-17 17 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
2023
Illuminating the Live-Cell Dynamics of Hepatitis B Virus Covalently Closed Circular DNA Using the CRISPR-Tag System
Ding, J., Yi, Z., Zai, W., Wu, M., Chen, B., Cai, Q., Zhang, X. & Yuan, Z., Mar 2023, In: mBio. 14, 2, p. 1-17 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus) -
2022
In situ analysis of hepatitis B virus (HBV) antigen and DNA in HBV-induced hepatocellular carcinoma
Zheng, Y., Xu, M., Zeng, D., Tong, H., Shi, Y., Feng, Y. & Zhang, X., Dec 2022, In: Diagnostic Pathology. 17, 1, 11.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)102 Downloads (Pure) -
Monocytic MDSCs homing to thymus contribute to age-related CD8+ T cell tolerance of HBV
Fang, Z., Zhang, Y., Zhu, Z., Wang, C., Hu, Y., Peng, X., Zhang, D., Zhao, J., Shi, B., Shen, Z., Wu, M., Xu, C., Chen, J., Zhou, X., Xie, Y., Yu, H., Zhang, X., Li, J., Hu, Y. & Kozlowski, M. & 2 others, , 4 Apr 2022, In: Journal of Experimental Medicine. 219, 4, p. 1-18 18 p., e20211838.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)31 Downloads (Pure) -
The Origin of Capsid-Derived Immune Complexes and their Impact on HBV-Induced Liver Diseases
Zhang, X., Tang, Y., Wu, M., Wang, C., Hu, L. & Zhang, Z., 12 Dec 2022, In: Viruses. 14, 12, p. 1-9 9 p., 2766.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)60 Downloads (Pure) -
The role of hepatitis B virus surface proteins in regulating the maturation and secretion of complete and incomplete virions
Xu, M., Li, C., Ding, J., Wu, M., Tang, Y., Yuan, Z. & Zhang, X., 2022, In: Journal of General Virology. 103, 4, p. 1-12 12 p., 001733.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)78 Downloads (Pure) -
2021
Animal Models for the Study of Hepatitis B Virus Pathobiology and Immunity: Past, Present, and Future
Zhang, X., Wang, X., Wu, M., Ghildyal, R. & Yuan, Z., 16 Jul 2021, In: Frontiers in Microbiology. 12, p. 1-10 10 p., 715450.Research output: Contribution to journal › Review article › peer-review
Open AccessFile15 Citations (Scopus)65 Downloads (Pure) -
Application of nanopore sequencing in diagnosis of secondary infections in patients with severe COVID-19
Jia, X., Zhang, X., Ling, Y., Zhang, X., Tian, D., Liao, Y., Yi, Z. & Lu, H., 25 Dec 2021, In: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 50, 6, p. 748-754 7 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
A streamlined clinical metagenomic sequencing protocol for rapid pathogen identification
Jia, X., Hu, L., Wu, M., Ling, Y., Wang, W., Lu, H., Yuan, Z., Yi, Z. & Zhang, X., Dec 2021, In: Scientific Reports. 11, 1, p. 4405 4405.Research output: Contribution to journal › Short Survey/Scientific Report › peer-review
Open AccessFile20 Citations (Scopus)93 Downloads (Pure) -
Co-infection in COVID-19, a cohort study
Song, W., Jia, X., Zhang, X., Ling, Y. & Yi, Z., Mar 2021, In: Journal of Infection. 82, 3, p. 440-442 3 p.Research output: Contribution to journal › Letter
Open Access7 Citations (Scopus) -
Evaluation of the in situ assay for HBV DNA: An observational real-world study in chronic hepatitis B
Li, C., Zhang, W., Shi, B., Chen, G., Zheng, Y., An, Y., Sun, M., Feng, Y., Shang, Q. & Zhang, X., 17 Sept 2021, In: Medicine. 100, 37, p. 1-7 7 p., e27220.Research output: Contribution to journal › Short Survey/Scientific Report › peer-review
Open Access3 Citations (Scopus) -
Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ Signaling
Chen, J., Li, Y., Lai, F., Wang, Y., Sutter, K., Dittmer, U., Ye, J., Zai, W., Liu, M., Shen, F., Wu, M., Hu, K., Li, B., Lu, M., Zhang, X., Zhang, J., Li, J., Chen, Q. & Yuan, Z., Feb 2021, In: Hepatology. 73, 2, p. 486-502 17 p.Research output: Contribution to journal › Review article › peer-review
57 Citations (Scopus) -
Probing the spatiotemporal patterns of HBV multiplication reveals novel features of its subcellular processes
Yue, L., Li, C., Xu, M., Wu, M., Ding, J., Liu, J., Zhang, X. & Yuan, Z., 9 Aug 2021, (E-pub ahead of print) In: PLoS Pathogens. 17, 8, p. 1-23 23 p., e1009838.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)102 Downloads (Pure) -
2020
An infectious clone of enterovirus 71(EV71) that is capable of infecting neonatal immune competent mice without adaptive mutations
Zhang, H., Song, Z., Zou, J., Feng, Y., Zhang, J., Ren, L., Zhang, X., Hu, Y., Yuan, Z. & Yi, Z., 1 Jan 2020, In: Emerging Microbes and Infections. 9, 1, p. 427-438 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)39 Downloads (Pure) -
An integrated software for virus community sequencing data analysis
Wang, M., Li, J., Zhang, X., Han, Y., Yu, D., Zhang, D., Yuan, Z., Yang, Z., Huang, J. & Zhang, X., 15 May 2020, In: BMC Genomics. 21, 1, p. 1-10 10 p., 363.Research output: Contribution to journal › Review article › peer-review
Open AccessFile4 Citations (Scopus)89 Downloads (Pure) -
A novel recombinant cccDNA-based mouse model with long term maintenance of rcccDNA and antigenemia
Wu, M., Wang, C., Shi, B., Fang, Z., Qin, B., Zhou, X., Zhang, X. & Yuan, Z., Aug 2020, In: Antiviral Research. 180, p. 1-10 10 p., 104826.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Clinical relevance of the in situ assay for HBV DNA: a cross-sectional study in patients with chronic hepatitis B
Liu, D., Xu, T., Shi, B., Lu, W., Zheng, Y., Feng, Y., Yuan, Z., Zhang, X. & Zhang, Z., Dec 2020, In: Journal of Clinical Pathology. 73, 12, p. 813-818 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)34 Downloads (Pure) -
Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19 convalescent population
Yi, Z., Ling, Y., Zhang, X., Chen, J., Hu, K., Wang, Y., Song, W., Ying, T., Zhang, R., Lu, H. & Yuan, Z., Dec 2020, In: Emerging Microbes and Infections. 9, 1, p. 1988-1996 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile49 Citations (Scopus)95 Downloads (Pure) -
Serum HBV RNA levels predict significant liver fibrosis in patients with chronic HBV infection
Huang, C., Li, Q., Xu, W., Wang, Q., Hu, Q., Zhang, X., Huang, Y. & Chen, L., 2 Oct 2020, In: Discovery medicine. 29, 157, p. 119-128 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Viral and host factors related to the clinical outcome of COVID-19
Zhang, X., Tan, Y., Ling, Y., Lu, G., Liu, F., Yi, Z., Jia, X., Wu, M., Shi, B., Xu, S., Chen, J., Wang, W., Chen, B., Jiang, L., Yu, S., Lu, J., Wang, J., Xu, M., Yuan, Z. & Zhang, Q. & 5 others, , Jul 2020, In: Nature. 583, 7816, p. 437-440 4 p.Research output: Contribution to journal › Article › peer-review
Open Access659 Citations (Scopus) -
2019
A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts
Xie, B., Sun, D., Du, Y., Jia, J., Sun, S., Xu, J., Liu, Y., Xiang, C., Chen, S., Xie, H., Wang, Q., Li, G., Lyu, X., Shen, H., Li, S., Wu, M., Zhang, X., Pu, Y., Xiang, K. & Lai, W. & 6 others, , Sept 2019, In: Cell Research. 29, 9, p. 696-710 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Citations (Scopus)156 Downloads (Pure) -
Long-term functional maintenance of primary human hepatocytes in vitro
Xiang, C., Du, Y., Meng, G., Soon Yi, L., Sun, S., Song, N., Zhang, X., Xiao, Y., Wang, J., Yi, Z., Liu, Y., Xie, B., Wu, M., Shu, J., Sun, D., Jia, J., Liang, Z., Sun, D., Huang, Y. & Shi, Y. & 7 others, , 26 Apr 2019, In: Science. 364, 6438, p. 399-402 4 p.Research output: Contribution to journal › Review article › peer-review
Open Access166 Citations (Scopus)29 Downloads (Pure) -
Visualization of macrophage lytic cell death during mycobacterial infection in zebrafish embryos via intravital microscopy
Niu, L., Wang, C., Zhang, K., Kang, M., Liang, R., Zhang, X. & Yan, B., 2019, In: Journal of Visualized Experiments. 2019, 143, p. 1-12 12 p., e60698.Research output: Contribution to journal › Review article › peer-review
6 Citations (Scopus) -
原位杂交技术在检测 HBV 核酸和 cccDNA 中的应用
Translated title of the contribution :Application of in situ hybridization in the detection of hepatitis B virus nucleic acids and cccDNA Research output: Contribution to journal › Review article › peer-review
-
2018
Differentially Expressed Intrahepatic Genes Contribute to Control of Hepatitis B Virus Replication in the Inactive Carrier Phase
Liu, H., Li, F., Zhang, X., Yu, J., Wang, J., Jia, J., Yu, X., Shen, Z., Yuan, Z., Zhang, X., Zhang, Z., Zhang, X., Lu, L., Li, H., Lu, M. & Zhang, J., 13 Mar 2018, In: Journal of Infectious Diseases. 217, 7, p. 1044-1054 11 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Citations (Scopus) -
Establishment of Cre-mediated HBV recombinant cccDNA (rcccDNA) cell line for cccDNA biology and antiviral screening assays
Wu, M., Li, J., Yue, L., Bai, L., Li, Y., Chen, J., Zhang, X. & Yuan, Z., Apr 2018, In: Antiviral Research. 152, p. 45-52 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)50 Downloads (Pure) -
Extracellular Hepatitis B Virus RNAs Are Heterogeneous in Length and Circulate as Capsid-Antibody Complexes in Addition to Virions in Chronic Hepatitis B Patients
Bai, L., Zhang, X., Kozlowski, M., Li, W., Wu, M., Liu, J., Chen, L., Zhang, J., Huang, Y. & Yuan, Z., 1 Dec 2018, In: Journal of Virology. 92, 24, p. 1-24 24 p., e0079818.Research output: Contribution to journal › Article › peer-review
Open Access66 Citations (Scopus) -
Performance of hepatitis B core-related antigen versus hepatitis B surface antigen and hepatitis B Virus DNA in predicting HBeAg-positive and HBeAg-negative chronic hepatitis
Zhang, Z. Q., Wang, Y. B., Lu, W., Liu, D. P., Shi, B. S., Zhang, X. N., Huang, D., Li, X. F., Zhou, X. L. & Ding, R. R., 2018, In: Annals of Laboratory Medicine. 39, 1, p. 67-75 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)63 Downloads (Pure) -
2017
Characterization of gene expression profiles in HBV-related liver fibrosis patients and identification of ITGBL1 as a key regulator of fibrogenesis
Wang, M., Gong, Q., Zhang, J., Chen, L., Zhang, Z., Lu, L., Yu, D., Han, Y., Zhang, D., Chen, P., Zhang, X., Yuan, Z., Huang, J. & Zhang, X., 6 Mar 2017, In: Scientific Reports. 7, p. 1-13 13 p., 43446.Research output: Contribution to journal › Article › peer-review
Open AccessFile92 Citations (Scopus)43 Downloads (Pure) -
Circulating miR-210 and miR-22 combined with ALT predict the virological response to interferon-alpha therapy of CHB patients
Li, J., Zhang, X., Chen, L., Zhang, Z., Zhang, J., Wang, W., Wu, M., Shi, B., Zhang, X., Kozlowski, M., Hu, Y. & Yuan, Z., 1 Dec 2017, In: Scientific Reports. 7, 1, p. 1-10 10 p., 15658.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)43 Downloads (Pure) -
Clinicopathologic characteristics of HIV/AIDS-related plasmablastic lymphoma
Wang, D., Zheng, Y., Zeng, D., Yang, Y., Zhang, X., Feng, Y. & Lu, H., 1 Mar 2017, In: International Journal of STD and AIDS. 28, 4, p. 380-388 9 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Establishment of a fluorescent in situ hybridization assay for imaging hepatitis B virus nucleic acids in cell culture models
Zhang, X., Yue, L., Zhang, Z. & Yuan, Z., 8 Nov 2017, In: Emerging Microbes and Infections. 6, 1, p. 1-6 6 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile12 Citations (Scopus)41 Downloads (Pure) -
Interplay between hepatitis B virus and the type I interferon system and new therapeutic strategies
Chen, J. L., Li, J. H., Zhang, X. N., Wu, M., Shi, B. S., Fang, Z. & Yuan, Z. H., 25 Nov 2017, In: Fudan University Journal of Medical Sciences. 44, 6, p. 793-798 6 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Label-free proteomic analysis of exosomes derived from inducible hepatitis B virus-replicating HepAD38 cell line
Jia, X., Chen, J., Megger, D. A., Zhang, X., Kozlowski, M., Zhang, L., Fang, Z., Li, J., Chu, Q., Wu, M., Li, Y., Sitek, B. & Yuan, Z., Apr 2017, In: Molecular and Cellular Proteomics. 16, 4, p. 144-160 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile55 Citations (Scopus)93 Downloads (Pure) -
Predictive model for inflammation grades of chronic hepatitis B: Large-scale analysis of clinical parameters and gene expressions
Zhou, W., Ma, Y., Zhang, J., Hu, J., Zhang, M., Wang, Y., Li, Y., Wu, L., Pan, Y., Zhang, Y., Zhang, X., Zhang, X., Zhang, Z., Zhang, J., Li, H., Lu, L., Jin, L., Wang, J., Yuan, Z. & Liu, J., Nov 2017, In: Liver International. 37, 11, p. 1632-1641 10 p.Research output: Contribution to journal › Article › peer-review
58 Citations (Scopus) -
PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation
Zhang, W., Chen, J., Wu, M., Zhang, X., Zhang, M., Yue, L., Li, Y., Liu, J., Li, B., Shen, F., Wang, Y., Bai, L., Protzer, U., Levrero, M. & Yuan, Z., Aug 2017, In: Journal of Hepatology and Gastroenterology. 66, 2, p. 398-415 18 p.Research output: Contribution to journal › Article › peer-review
Open Access126 Citations (Scopus) -
2016
A Pilot Study of MicroRNAs Expression Profile in Serum and HBsAg Particles: Predictors of Therapeutic Vaccine Efficacy in Chronic Hepatitis B Patients
Wang, W., Li, J., Zhang, X., Wen, Y., Wang, X.-Y. & Yuan, Z., Jan 2016, In: Medicine. 95, 2, p. 1-8 8 p., e2511.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
In situ analysis of intrahepatic virological events in chronic hepatitis B virus infection
Zhang, X., Lu, W., Zheng, Y., Wang, W., Bai, L., Chen, L., Feng, Y., Zhang, Z. & Yuan, Z., 1 Mar 2016, In: Journal of Clinical Investigation. 126, 3, p. 1079-1092 14 p.Research output: Contribution to journal › Article › peer-review
Open Access94 Citations (Scopus) -
Involvement of Lysosome Membrane Permeabilization and Reactive Oxygen Species Production in the Necrosis Induced by Chlamydia muridarum Infection in L929 Cells
Chen, L., Wang, C., Li, S., Yu, X., Liu, X., Ren, R., Liu, W., Zhou, X., Zhang, X. & Zhou, X., 28 Apr 2016, In: Journal of Microbiology and Biotechnology. 26, 4, p. 790-798 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)52 Downloads (Pure) -
MicroRNA-939 restricts Hepatitis B virus by targeting Jmjd3-mediated and C/EBPα-coordinated chromatin remodeling
Chen, C., Wu, M., Zhang, W., Lu, W., Zhang, M., Zhang, Z., Zhang, X. & Yuan, Z., 25 Oct 2016, In: Scientific Reports. 6, p. 1-15 15 p., 35974.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)73 Downloads (Pure) -
The discovery and characterization of a novel scaffold as a potent hepatitis C virus inhibitor
Liu, N., Zhu, S., Zhang, X., Yin, X., Dong, G., Yao, J., Miao, Z., Zhang, W., Zhang, X. & Sheng, C., 25 Feb 2016, In: Chemical Communications. 52, 16, p. 3340-3343 4 p.Research output: Contribution to journal › Review article › peer-review
8 Citations (Scopus) -
2015
Extra-pulmonary viral shedding in H7N9 Avian Influenza patients
Zhu, Z., Liu, Y., Xu, L., Guan, W., Zhang, X., Qi, T., Shi, B., Song, Z., Liu, X., Wan, Y., Tian, D., He, J., Zhang, X., Wu, M., Lu, H., Lu, S., Zhang, Z., Yuan, Z. & Hu, Y., Aug 2015, In: Clinical and Diagnostic Virology. 69, p. 30-32 3 p.Research output: Contribution to journal › Comment/debate
25 Citations (Scopus) -
Genetic and phenotypic characterization of Candida albicans strains isolated from infectious disease patients in Shanghai
Hu, L., Du, X., Li, T., Song, Y., Zai, S., Hu, X., Zhang, X. & Li, M., Jan 2015, In: Journal of Medical Microbiology. 64, 1, p. 74-83 10 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Citations (Scopus) -
Hepatitis B virus spliced variants are associated with an impaired response to interferon therapy
Chen, J., Wu, M., Wang, F., Zhang, W., Wang, W., Zhang, X., Zhang, J., Liu, Y., Liu, Y., Feng, Y., Zheng, Y., Hu, Y. & Yuan, Z., 20 Nov 2015, In: Scientific Reports. 5, p. 16459 16459.Research output: Contribution to journal › Article › peer-review
Open AccessFile58 Citations (Scopus)47 Downloads (Pure)