The development of an effective antigen delivery technology for enhancing mucosal immunisation

Strategies will be conducted to develop effective technologies to optimise immunity induced by orally administered antigens. These include increasing the efficiency of antigen uptake by M-cells, increasing M-cell (and lymphoid) mass in the intestine and the development of an antigen release technology to release antigen in proportion to the M-cell mass along the intestine. This proposal aims to overcome this problem at the fundamental level and provide a generic basis for vaccine formulation by the oral route.