Togavirus Tropism for Bones, Joints and CNS

VIrus-induced inflammatory diseases, including arthritis, pneumonia, and encephalitis, are a significant cause of human disease, and there is a clear need to improve our overall understanding of the pathogenesis of this diverse array of conditions.Togaviruses, which include the mosquito-borne alphaviruses such as Chikungunya, O'nyong-nyong, and Ross River virus cause massive outbreaks of infectious arthritis/athralgia/myalgia and affected thousands to millions of individuals and continues to be an emerging threat. The project will models to study how the virus replicates.