α1– Antitrypsin: Anti-inflammatory roles in exercise and atherosclerosis

Research output: Contribution to journalLiterature review

Abstract

α1-Antitrypsin, also known as serum trypsin inhibitor, is an acute phase protein that is upregulated in response to tissue damage and infection. More specifically this glycoprotein affords the host protection against enzymes that are released by immune inflammatory cells. The most notable of these enzymes is neutrophil elastase. Neutrophil elastase has the ability to damage vasculature and in doing so may contribute to atherosclerosis and other chronic diseases in which inflammation is an integral component of the pathology. Exercise has recently been defined as anti-inflammatory in nature, however, the complex mechanism underlying this beneficial effect is not fully understood. This paper provides an overview of the roles that α1-antitrypsin may play in atherogenesis, summarises the findings from exercise studies in which α1-antitrypsin was measured, and proposes that transient exercise induced elevations in α1-antitrypsin may potentially contribute to the anti-inflammatory effect of exercise.
Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalAfrican Journal of Biochemistry Research
Volume5
Issue number5
Publication statusPublished - 2011
Externally publishedYes

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Leukocyte Elastase
Atherosclerosis
Anti-Inflammatory Agents
Trypsin Inhibitors
Acute-Phase Proteins
Enzymes
Glycoproteins
Chronic Disease
Pathology
Inflammation
Infection
Serum

Cite this

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title = "α1– Antitrypsin: Anti-inflammatory roles in exercise and atherosclerosis",
abstract = "α1-Antitrypsin, also known as serum trypsin inhibitor, is an acute phase protein that is upregulated in response to tissue damage and infection. More specifically this glycoprotein affords the host protection against enzymes that are released by immune inflammatory cells. The most notable of these enzymes is neutrophil elastase. Neutrophil elastase has the ability to damage vasculature and in doing so may contribute to atherosclerosis and other chronic diseases in which inflammation is an integral component of the pathology. Exercise has recently been defined as anti-inflammatory in nature, however, the complex mechanism underlying this beneficial effect is not fully understood. This paper provides an overview of the roles that α1-antitrypsin may play in atherogenesis, summarises the findings from exercise studies in which α1-antitrypsin was measured, and proposes that transient exercise induced elevations in α1-antitrypsin may potentially contribute to the anti-inflammatory effect of exercise.",
author = "Stuart SEMPLE and Andrew MCKUNE",
year = "2011",
language = "English",
volume = "5",
pages = "143--147",
journal = "African Journal of Biochemistry Research",
issn = "1996-0778",
number = "5",

}

α1– Antitrypsin: Anti-inflammatory roles in exercise and atherosclerosis. / SEMPLE, Stuart; MCKUNE, Andrew.

In: African Journal of Biochemistry Research, Vol. 5, No. 5, 2011, p. 143-147.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - α1– Antitrypsin: Anti-inflammatory roles in exercise and atherosclerosis

AU - SEMPLE, Stuart

AU - MCKUNE, Andrew

PY - 2011

Y1 - 2011

N2 - α1-Antitrypsin, also known as serum trypsin inhibitor, is an acute phase protein that is upregulated in response to tissue damage and infection. More specifically this glycoprotein affords the host protection against enzymes that are released by immune inflammatory cells. The most notable of these enzymes is neutrophil elastase. Neutrophil elastase has the ability to damage vasculature and in doing so may contribute to atherosclerosis and other chronic diseases in which inflammation is an integral component of the pathology. Exercise has recently been defined as anti-inflammatory in nature, however, the complex mechanism underlying this beneficial effect is not fully understood. This paper provides an overview of the roles that α1-antitrypsin may play in atherogenesis, summarises the findings from exercise studies in which α1-antitrypsin was measured, and proposes that transient exercise induced elevations in α1-antitrypsin may potentially contribute to the anti-inflammatory effect of exercise.

AB - α1-Antitrypsin, also known as serum trypsin inhibitor, is an acute phase protein that is upregulated in response to tissue damage and infection. More specifically this glycoprotein affords the host protection against enzymes that are released by immune inflammatory cells. The most notable of these enzymes is neutrophil elastase. Neutrophil elastase has the ability to damage vasculature and in doing so may contribute to atherosclerosis and other chronic diseases in which inflammation is an integral component of the pathology. Exercise has recently been defined as anti-inflammatory in nature, however, the complex mechanism underlying this beneficial effect is not fully understood. This paper provides an overview of the roles that α1-antitrypsin may play in atherogenesis, summarises the findings from exercise studies in which α1-antitrypsin was measured, and proposes that transient exercise induced elevations in α1-antitrypsin may potentially contribute to the anti-inflammatory effect of exercise.

M3 - Literature review

VL - 5

SP - 143

EP - 147

JO - African Journal of Biochemistry Research

JF - African Journal of Biochemistry Research

SN - 1996-0778

IS - 5

ER -