A novel role of probiotics in improving host defence of elite rugby union athlete: A double blind randomised controlled trial

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Abstract

Objective: To examine the effects of a probiotic protocol on the incidence and severity of respiratory and gastrointestinal infections in elite rugby union athletes across an international competition season. Associations were also investigated between salivary biomarkers of stress (cortisol, alpha-amylase) and mucosal immunity (secretory(s)-IgA). Design: A double-blind RCT was conducted over 27-weeks, divided into three stages: (1) control period; (2) domestic competition; and (3) international competition. Methods: Athletes were assigned a probiotic (n = 9) or placebo (n = 10) supplement. Ultrabiotic 60™ or placebo was taken with food twice daily for 17 weeks and SB Floractiv™ 250 mg added twice daily during stage three. Results: Five infections were diagnosed by the team sports physician across the 27-weeks, three within the intervention period in athletes randomised to the placebo group. No significant group x time interaction effects for salivary cortisol, alpha-amylase or s-IgA were identified over the 27-week time period, although a significant main effect for group and time was identified for salivary cortisol, alpha-amylase, and s-IgA (p < 0.05 for all). When considering stage, significant differences were identified in stage one with s-IgA lower in the probiotic group (p = 0.015). In stage two and three, salivary cortisol was higher in the probiotic group (p = 0.016 and p = 0.001 respectively), and salivary alpha-amylase was higher in the probiotic group in stage three (p = 0.007). Conclusion: The probiotic protocol used in this study was associated with an increase in salivary alpha-amylase supporting its possible role as a host defence peptide.

LanguageEnglish
Pages876-881
Number of pages6
JournalJournal of Science and Medicine in Sport
Volume22
Issue number8
Early online date2019
DOIs
Publication statusE-pub ahead of print - 2019

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Football
Probiotics
Salivary alpha-Amylases
Athletes
Randomized Controlled Trials
Hydrocortisone
Immunoglobulin A
Placebos
Secretory Immunoglobulin A
Mucosal Immunity
alpha-Amylases
Respiratory Tract Infections
Sports
Biomarkers
Physicians
Food
Peptides
Incidence
Infection

Cite this

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title = "A novel role of probiotics in improving host defence of elite rugby union athlete: A double blind randomised controlled trial",
abstract = "Objective: To examine the effects of a probiotic protocol on the incidence and severity of respiratory and gastrointestinal infections in elite rugby union athletes across an international competition season. Associations were also investigated between salivary biomarkers of stress (cortisol, alpha-amylase) and mucosal immunity (secretory(s)-IgA). Design: A double-blind RCT was conducted over 27-weeks, divided into three stages: (1) control period; (2) domestic competition; and (3) international competition. Methods: Athletes were assigned a probiotic (n = 9) or placebo (n = 10) supplement. Ultrabiotic 60™ or placebo was taken with food twice daily for 17 weeks and SB Floractiv™ 250 mg added twice daily during stage three. Results: Five infections were diagnosed by the team sports physician across the 27-weeks, three within the intervention period in athletes randomised to the placebo group. No significant group x time interaction effects for salivary cortisol, alpha-amylase or s-IgA were identified over the 27-week time period, although a significant main effect for group and time was identified for salivary cortisol, alpha-amylase, and s-IgA (p < 0.05 for all). When considering stage, significant differences were identified in stage one with s-IgA lower in the probiotic group (p = 0.015). In stage two and three, salivary cortisol was higher in the probiotic group (p = 0.016 and p = 0.001 respectively), and salivary alpha-amylase was higher in the probiotic group in stage three (p = 0.007). Conclusion: The probiotic protocol used in this study was associated with an increase in salivary alpha-amylase supporting its possible role as a host defence peptide.",
keywords = "Alpha amylase, Elite athlete, Illness, Immunity, Stress, Travel",
author = "Pumpa, {Kate L.} and McKune, {Andrew J.} and Joanna Harnett",
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TY - JOUR

T1 - A novel role of probiotics in improving host defence of elite rugby union athlete

T2 - Australian Journal of Science and Medicine in Sport

AU - Pumpa, Kate L.

AU - McKune, Andrew J.

AU - Harnett, Joanna

PY - 2019

Y1 - 2019

N2 - Objective: To examine the effects of a probiotic protocol on the incidence and severity of respiratory and gastrointestinal infections in elite rugby union athletes across an international competition season. Associations were also investigated between salivary biomarkers of stress (cortisol, alpha-amylase) and mucosal immunity (secretory(s)-IgA). Design: A double-blind RCT was conducted over 27-weeks, divided into three stages: (1) control period; (2) domestic competition; and (3) international competition. Methods: Athletes were assigned a probiotic (n = 9) or placebo (n = 10) supplement. Ultrabiotic 60™ or placebo was taken with food twice daily for 17 weeks and SB Floractiv™ 250 mg added twice daily during stage three. Results: Five infections were diagnosed by the team sports physician across the 27-weeks, three within the intervention period in athletes randomised to the placebo group. No significant group x time interaction effects for salivary cortisol, alpha-amylase or s-IgA were identified over the 27-week time period, although a significant main effect for group and time was identified for salivary cortisol, alpha-amylase, and s-IgA (p < 0.05 for all). When considering stage, significant differences were identified in stage one with s-IgA lower in the probiotic group (p = 0.015). In stage two and three, salivary cortisol was higher in the probiotic group (p = 0.016 and p = 0.001 respectively), and salivary alpha-amylase was higher in the probiotic group in stage three (p = 0.007). Conclusion: The probiotic protocol used in this study was associated with an increase in salivary alpha-amylase supporting its possible role as a host defence peptide.

AB - Objective: To examine the effects of a probiotic protocol on the incidence and severity of respiratory and gastrointestinal infections in elite rugby union athletes across an international competition season. Associations were also investigated between salivary biomarkers of stress (cortisol, alpha-amylase) and mucosal immunity (secretory(s)-IgA). Design: A double-blind RCT was conducted over 27-weeks, divided into three stages: (1) control period; (2) domestic competition; and (3) international competition. Methods: Athletes were assigned a probiotic (n = 9) or placebo (n = 10) supplement. Ultrabiotic 60™ or placebo was taken with food twice daily for 17 weeks and SB Floractiv™ 250 mg added twice daily during stage three. Results: Five infections were diagnosed by the team sports physician across the 27-weeks, three within the intervention period in athletes randomised to the placebo group. No significant group x time interaction effects for salivary cortisol, alpha-amylase or s-IgA were identified over the 27-week time period, although a significant main effect for group and time was identified for salivary cortisol, alpha-amylase, and s-IgA (p < 0.05 for all). When considering stage, significant differences were identified in stage one with s-IgA lower in the probiotic group (p = 0.015). In stage two and three, salivary cortisol was higher in the probiotic group (p = 0.016 and p = 0.001 respectively), and salivary alpha-amylase was higher in the probiotic group in stage three (p = 0.007). Conclusion: The probiotic protocol used in this study was associated with an increase in salivary alpha-amylase supporting its possible role as a host defence peptide.

KW - Alpha amylase

KW - Elite athlete

KW - Illness

KW - Immunity

KW - Stress

KW - Travel

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UR - http://www.mendeley.com/research/novel-role-probiotics-improving-host-defence-elite-rugby-union-athlete-double-blind-randomised-contr

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DO - 10.1016/j.jsams.2019.03.013

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EP - 881

JO - Australian Journal of Science and Medicine in Sport

JF - Australian Journal of Science and Medicine in Sport

SN - 1440-2440

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