A Pattern Recognition Bioinformatics Alternative System to Rodent Models in Fundamental Research

Brett Lidbury, Alice Richardson

Research output: A Conference proceeding or a Chapter in BookConference contribution

Abstract

Reliance upon rodent models in fundamental biomedical research is increasing due to technologies that allow the genetic engineering of inbred mouse strains. Through these genetic technologies and other established benefits for biomedical research success, there is a rodent-based experimental “system” that serves the researcher’s needs for whole organism experimentation. Furthermore, it is accepted that medical advances require an “animal model” as an essential aspect to ultimate success. Direct studies on humans are seen to be problematic due to significant heterogeneity and diversity in human populations. Modern bioinformatics, particularly the pattern recognition field, provides potential answers to the problem of overcoming such outbred diversity. Advanced statistical methods and machine learning algorithms developed by computer scientists, for example recursive partitioning and support vector machines (SVMs), applied to human biomedical data, provide a basis for an alternative system to mouse models through unravelling diversity and providing clues to guide investigations into human disease.
Original languageEnglish
Title of host publicationProceedings of the 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montreal 2011
EditorsSvon Aulock, F P Gmber, P Magr, C Rauter Gknimuluache
Place of PublicationSwitzerland
PublisherSpringer
Pages515-520
Number of pages6
Volume1
Publication statusPublished - 2012
EventWC8 - Montreal, Canada
Duration: 21 Aug 201125 Aug 2011

Publication series

NameALTEX Proceedings
PublisherSpringer
Number1
Volume1
ISSN (Print)2194-0479

Conference

ConferenceWC8
CountryCanada
CityMontreal
Period21/08/1125/08/11

Fingerprint

Bioinformatics
Pattern recognition
Genetic engineering
Bioelectric potentials
Learning algorithms
Support vector machines
Learning systems
Statistical methods
Animals
Rodentia

Cite this

Lidbury, B., & Richardson, A. (2012). A Pattern Recognition Bioinformatics Alternative System to Rodent Models in Fundamental Research. In S. Aulock, F. P. Gmber, P. Magr, & C. R. Gknimuluache (Eds.), Proceedings of the 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montreal 2011 (Vol. 1, pp. 515-520). (ALTEX Proceedings; Vol. 1, No. 1). Switzerland: Springer.
Lidbury, Brett ; Richardson, Alice. / A Pattern Recognition Bioinformatics Alternative System to Rodent Models in Fundamental Research. Proceedings of the 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montreal 2011 . editor / Svon Aulock ; F P Gmber ; P Magr ; C Rauter Gknimuluache. Vol. 1 Switzerland : Springer, 2012. pp. 515-520 (ALTEX Proceedings; 1).
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abstract = "Reliance upon rodent models in fundamental biomedical research is increasing due to technologies that allow the genetic engineering of inbred mouse strains. Through these genetic technologies and other established benefits for biomedical research success, there is a rodent-based experimental “system” that serves the researcher’s needs for whole organism experimentation. Furthermore, it is accepted that medical advances require an “animal model” as an essential aspect to ultimate success. Direct studies on humans are seen to be problematic due to significant heterogeneity and diversity in human populations. Modern bioinformatics, particularly the pattern recognition field, provides potential answers to the problem of overcoming such outbred diversity. Advanced statistical methods and machine learning algorithms developed by computer scientists, for example recursive partitioning and support vector machines (SVMs), applied to human biomedical data, provide a basis for an alternative system to mouse models through unravelling diversity and providing clues to guide investigations into human disease.",
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Lidbury, B & Richardson, A 2012, A Pattern Recognition Bioinformatics Alternative System to Rodent Models in Fundamental Research. in S Aulock, FP Gmber, P Magr & CR Gknimuluache (eds), Proceedings of the 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montreal 2011 . vol. 1, ALTEX Proceedings, no. 1, vol. 1, Springer, Switzerland, pp. 515-520, WC8, Montreal, Canada, 21/08/11.

A Pattern Recognition Bioinformatics Alternative System to Rodent Models in Fundamental Research. / Lidbury, Brett; Richardson, Alice.

Proceedings of the 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montreal 2011 . ed. / Svon Aulock; F P Gmber; P Magr; C Rauter Gknimuluache. Vol. 1 Switzerland : Springer, 2012. p. 515-520 (ALTEX Proceedings; Vol. 1, No. 1).

Research output: A Conference proceeding or a Chapter in BookConference contribution

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AU - Lidbury, Brett

AU - Richardson, Alice

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AB - Reliance upon rodent models in fundamental biomedical research is increasing due to technologies that allow the genetic engineering of inbred mouse strains. Through these genetic technologies and other established benefits for biomedical research success, there is a rodent-based experimental “system” that serves the researcher’s needs for whole organism experimentation. Furthermore, it is accepted that medical advances require an “animal model” as an essential aspect to ultimate success. Direct studies on humans are seen to be problematic due to significant heterogeneity and diversity in human populations. Modern bioinformatics, particularly the pattern recognition field, provides potential answers to the problem of overcoming such outbred diversity. Advanced statistical methods and machine learning algorithms developed by computer scientists, for example recursive partitioning and support vector machines (SVMs), applied to human biomedical data, provide a basis for an alternative system to mouse models through unravelling diversity and providing clues to guide investigations into human disease.

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Lidbury B, Richardson A. A Pattern Recognition Bioinformatics Alternative System to Rodent Models in Fundamental Research. In Aulock S, Gmber FP, Magr P, Gknimuluache CR, editors, Proceedings of the 8th World Congress on Alternatives and Animal Use in the Life Sciences, Montreal 2011 . Vol. 1. Switzerland: Springer. 2012. p. 515-520. (ALTEX Proceedings; 1).