A pilot randomised clinical trial of 670 nm red light for reducing retinopathy of prematurity

Alison L. Kent, Mohamed E. Abdel-Latif, Timothy Cochrane, Margaret Broom, Jane E. Dahlstrom, Rohan W. Essex, Bruce Shadbolt, Riccardo Natoli

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background: Photobiomodulation by 670 nm red light in animal models reduced severity of ROP and improved survival. This pilot randomised controlled trial aimed to provide data on 670 nm red light exposure for prevention of ROP and survival for a larger randomised trial. Methods: Neonates <30 weeks gestation or <1150 g at birth were randomised to receive 670 nm for 15 min (9 J/cm2) daily until 34 weeks corrected age. Data collected: placental pathology, growth, days of respiratory support and oxygen, bronchopulmonary dysplasia, patent ductus arteriosus, necrotising enterocolitis, sepsis, worst stage of ROP, need for laser treatment, and survival. Results: Eighty-six neonates enrolled—45 no red light; 41 red light. There was no difference in severity of ROP (<27 weeks—p = 0.463; ≥27 weeks—p = 0.558) or requirement for laser treatment (<27 weeks—p = 1.00; ≥27 weeks—no laser treatment in either group). Survival in 670 nm red light treatment group was 100% (41/41) vs 89% (40/45) in untreated infants (p = 0.057). Conclusion: Randomisation to receive 670 nm red light within 24–48 h after birth is feasible. Although no improvement in ROP or survivability was observed, further testing into the dosage and delivery for this potential therapy are required.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalPediatric Research
Issue number1
Publication statusPublished - 1 Jan 2020
Externally publishedYes


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