@article{1480ad80750147ada6a0524007c44788,
title = "A randomised controlled trial of consumption of dark chocolate in pregnancy to reduce pre-eclampsia: Difficulties in recruitment, allocation and adherence",
abstract = "In 2013–2014 we undertook a randomised controlled trial (RCT) to determine whether the daily ingestion of dark chocolate during pregnancy could reduce the incidence of pre-eclampsia in primigravidae. However, after two years we had not succeeded in recruiting more than 3.5% of the number of participants required to answer the research question, and the trial was halted. We also reviewed the literature on this topic and found it to be limited. We report here our findings and discuss the difficulties facing researchers in this area.",
keywords = "dark chocolate, dark chocolate in pregnancy, flavonoid rich dark chocolate, pre-eclampsia",
author = "Subashini Gnanendran and Jemma Porrett and Cindy Woods and Maryke Buttrose and Clare Jukka and Jane Hollins and Stephen Robson and {de Costa}, Caroline",
note = "Funding Information: 16. McDonald AM, Knight RC, Campbell MK et al. What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies. Trials 2006; 7(1): 9. Publisher Copyright: {\textcopyright} 2017 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists",
year = "2018",
month = jun,
doi = "10.1111/ajo.12694",
language = "English",
volume = "58",
pages = "358--361",
journal = "Australian and New Zealand Journal of Obstetrics and Gynaecology",
issn = "0004-8666",
publisher = "Wiley-Blackwell",
number = "3",
}