TY - JOUR
T1 - A randomized-controlled study of a modified technique to reduce extracardiac activity in myocardial perfusion imaging
AU - Bresser, Philippa L.
AU - Sathekge, Mike M.
AU - Makanjee, Chandra R.
AU - Van Wyk, Delene
AU - Vorster, Mariza
PY - 2017/1
Y1 - 2017/1
N2 - Introduction: Various techniques have been used in an attempt to reduce interfering extra cardiac activity in myocardial perfusion imaging with inconsistent results. The aim of this study was to investigate the effect of a combined intervention on the frequency and intensity of interfering extra cardiac activity.
Methods: Patients (n=230) routinely referred for a 2-day stress-rest myocardial perfusion examination were assigned randomly to one of two groups. Group A (n=114) received a single intervention (diluted lemon juice) before stress imaging and a combined intervention (diluted lemon juice and soda water) before rest imaging. Interventions were reversed for group B (n=116). Three interpreters, blinded to the intervention, assessed early and delayed planar images from 195 patients in terms of the frequency and the intensity of interfering extra cardiac activity.
Results: The myocardial to extra cardiac (MYO : EXC) ratio between groups for the rest studies was marginally not significant (P=0.060 and 0.059), showing an increase in ratio when the combined intervention was administered. There were significant differences (P<=0.001) in the frequency, intensity, and MYO : EXC ratio between the early and the delayed studies.
Conclusion: Combining interventions that stimulate radiopharmaceutical hepatic excretion and utilize the volume effect is advantageous in myocardial perfusion imaging, with delayed imaging being advocated as a complementary intervention.
AB - Introduction: Various techniques have been used in an attempt to reduce interfering extra cardiac activity in myocardial perfusion imaging with inconsistent results. The aim of this study was to investigate the effect of a combined intervention on the frequency and intensity of interfering extra cardiac activity.
Methods: Patients (n=230) routinely referred for a 2-day stress-rest myocardial perfusion examination were assigned randomly to one of two groups. Group A (n=114) received a single intervention (diluted lemon juice) before stress imaging and a combined intervention (diluted lemon juice and soda water) before rest imaging. Interventions were reversed for group B (n=116). Three interpreters, blinded to the intervention, assessed early and delayed planar images from 195 patients in terms of the frequency and the intensity of interfering extra cardiac activity.
Results: The myocardial to extra cardiac (MYO : EXC) ratio between groups for the rest studies was marginally not significant (P=0.060 and 0.059), showing an increase in ratio when the combined intervention was administered. There were significant differences (P<=0.001) in the frequency, intensity, and MYO : EXC ratio between the early and the delayed studies.
Conclusion: Combining interventions that stimulate radiopharmaceutical hepatic excretion and utilize the volume effect is advantageous in myocardial perfusion imaging, with delayed imaging being advocated as a complementary intervention.
KW - hepatobiliary clearance
KW - interfering extracardiac activity
KW - modified intervention
KW - myocardial perfusion imaging
KW - volume effect
KW - Myocardial perfusion imaging
KW - Volume effect
KW - Modified intervention
KW - Hepatobiliary clearance
KW - Interfering extracardiac activity
UR - http://www.scopus.com/inward/record.url?scp=84991489098&partnerID=8YFLogxK
U2 - 10.1097/MNM.0000000000000600
DO - 10.1097/MNM.0000000000000600
M3 - Article
SN - 0143-3636
VL - 38
SP - 21
EP - 28
JO - Nuclear Medicine Communications
JF - Nuclear Medicine Communications
IS - 1
ER -