A review of complementary mechanisms which protect the developing marsupial pouch young

Melanie Edwards; Lyn Hinds; E. Deane; Janine Deakin

doi:10.1016/j.dci.2012.03.013

A review of complementary mechanisms which protect the developing marsupial pouch young

Melanie Edwards, Lyn Hinds, E. Deane, Janine Deakin

Science

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33 Citations (Scopus)

Abstract

Marsupials are born without a functioning adaptive immune system, into a non-sterile environment where they continue to develop. This review examines the extent of exposure of pouch young to microorganisms and describes the protective mechanisms that are complementary to adaptive immunity in the developing young. Complementary protective mechanisms include the role of the innate immune system and maternal protection strategies, such as immune compounds in milk, prenatal transfer of immunoglobulins, antimicrobial compounds secreted in the pouch, and chemical or mechanical cleaning of the pouch and pouch young.

Original language	English
Pages (from-to)	213-220
Number of pages	8
Journal	Developmental Comparative Immunology
Volume	37
DOIs	https://doi.org/10.1016/j.dci.2012.03.013
Publication status	Published - 2012

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10.1016/j.dci.2012.03.013

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abstract = "Marsupials are born without a functioning adaptive immune system, into a non-sterile environment where they continue to develop. This review examines the extent of exposure of pouch young to microorganisms and describes the protective mechanisms that are complementary to adaptive immunity in the developing young. Complementary protective mechanisms include the role of the innate immune system and maternal protection strategies, such as immune compounds in milk, prenatal transfer of immunoglobulins, antimicrobial compounds secreted in the pouch, and chemical or mechanical cleaning of the pouch and pouch young.",

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AU - Hinds, Lyn

AU - Deane, E.

AU - Deakin, Janine

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AB - Marsupials are born without a functioning adaptive immune system, into a non-sterile environment where they continue to develop. This review examines the extent of exposure of pouch young to microorganisms and describes the protective mechanisms that are complementary to adaptive immunity in the developing young. Complementary protective mechanisms include the role of the innate immune system and maternal protection strategies, such as immune compounds in milk, prenatal transfer of immunoglobulins, antimicrobial compounds secreted in the pouch, and chemical or mechanical cleaning of the pouch and pouch young.

KW - Marsupial

KW - Pouch young

KW - Adaptive immunity

KW - Innate immunity

KW - Maternal protection

U2 - 10.1016/j.dci.2012.03.013

DO - 10.1016/j.dci.2012.03.013

M3 - Article

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VL - 37

SP - 213

EP - 220

JO - Developmental Comparative Immunology

JF - Developmental Comparative Immunology

ER -

A review of complementary mechanisms which protect the developing marsupial pouch young

Abstract

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