A review of impurity profiling and synthetic route of manufacture of methylamphetamine, 3,4-methylene

Natasha Stojanovska, Shanlin Fu, Mark Tahtouh, Tamsin KELLY, Alison Beavis, Paul Kirkbride

    Research output: Contribution to journalArticle

    50 Citations (Scopus)

    Abstract

    Amphetamine-type substances (ATS), like other synthetically derived compounds, can be produced by a multitude of synthetic pathways using a variety of precursors and reagents, resulting in a large number of possible contaminants (by-products, intermediates and impurities). This review article describes the common contaminants found in preparations of methylamphetamine (MA), 3,4-methylenedioxymethylamphetamine (MDMA), amphetamine (AP), N,N-dimethylamphetamine (DMA) and p-methoxyamphetamine (PMA) synthesised via common synthetic pathways including reductive amination, Leuckart method, Nagai method, Emde method, Birch reduction, “Moscow” method, Wacker process, “Nitrostyrene” method and the Peracid oxidation method.

    Contaminants can facilitate identification of the synthetic route, origin of precursors and may suggest information as to the location of manufacture of these illicit drugs. Contaminant profiling can provide vital intelligence for investigations in which linking seizures or identifying the synthetic pathway is essential. This review article presents an accessible resource; a compilation of contaminants resulting from a variety of manufacturing methods used to synthesise the most common ATS. It is important for research in this field to continue as valuable information can be extracted from illicit drug samples, increasing discrimination amongst ATS, and in turn, leading to an increase in evidential value and forensic drug intelligence from forensic drug samples
    Original languageEnglish
    Pages (from-to)8-26
    Number of pages19
    JournalForensic Science International
    Volume224
    Issue number1-3
    DOIs
    Publication statusPublished - 2013

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    Amphetamine
    Street Drugs
    Intelligence
    Amination
    Betula
    Moscow
    3-methylamphetamine
    1-(4-methylphenyl)propane-2-amine
    Pharmaceutical Preparations
    Seizures
    Research

    Cite this

    Stojanovska, Natasha ; Fu, Shanlin ; Tahtouh, Mark ; KELLY, Tamsin ; Beavis, Alison ; Kirkbride, Paul. / A review of impurity profiling and synthetic route of manufacture of methylamphetamine, 3,4-methylene. In: Forensic Science International. 2013 ; Vol. 224, No. 1-3. pp. 8-26.
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    abstract = "Amphetamine-type substances (ATS), like other synthetically derived compounds, can be produced by a multitude of synthetic pathways using a variety of precursors and reagents, resulting in a large number of possible contaminants (by-products, intermediates and impurities). This review article describes the common contaminants found in preparations of methylamphetamine (MA), 3,4-methylenedioxymethylamphetamine (MDMA), amphetamine (AP), N,N-dimethylamphetamine (DMA) and p-methoxyamphetamine (PMA) synthesised via common synthetic pathways including reductive amination, Leuckart method, Nagai method, Emde method, Birch reduction, “Moscow” method, Wacker process, “Nitrostyrene” method and the Peracid oxidation method.Contaminants can facilitate identification of the synthetic route, origin of precursors and may suggest information as to the location of manufacture of these illicit drugs. Contaminant profiling can provide vital intelligence for investigations in which linking seizures or identifying the synthetic pathway is essential. This review article presents an accessible resource; a compilation of contaminants resulting from a variety of manufacturing methods used to synthesise the most common ATS. It is important for research in this field to continue as valuable information can be extracted from illicit drug samples, increasing discrimination amongst ATS, and in turn, leading to an increase in evidential value and forensic drug intelligence from forensic drug samples",
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    A review of impurity profiling and synthetic route of manufacture of methylamphetamine, 3,4-methylene. / Stojanovska, Natasha; Fu, Shanlin; Tahtouh, Mark; KELLY, Tamsin; Beavis, Alison; Kirkbride, Paul.

    In: Forensic Science International, Vol. 224, No. 1-3, 2013, p. 8-26.

    Research output: Contribution to journalArticle

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