@article{86af1fba9dfb489885ed29b2e172b28e,
title = "A Sendai virus recombinant vaccine expressing a gene for truncated human metapneumovirus (hMPV) fusion protein protects cotton rats from hMPV challenge",
abstract = "Human metapneumovirus (hMPV) infections pose a serious health risk to young children, particularly in cases of premature birth. No licensed vaccine exists and there is no standard treatment for hMPV infections apart from supportive hospital care. We describe the production of a Sendai virus (SeV) recombinant that carries a gene for a truncated hMPV fusion (F) protein (SeV-MPV-Ft). The vaccine induces binding and neutralizing antibody responses toward hMPV and protection against challenge with hMPV in a cotton rat system. Results encourage advanced development of SeV-MPV-Ft to prevent the morbidity and mortality caused by hMPV infections in young children.",
keywords = "Immunity, Metapneumovirus, Neutralizing antibodies, Recombinant vaccine, Respiratory virus, Sendai virus",
author = "Russell, {Charles J.} and Jones, {Bart G.} and Sealy, {Robert E.} and Surman, {Sherri L.} and Mason, {John N.} and Hayden, {Randall T.} and Tripp, {Ralph A.} and Toru Takimoto and Hurwitz, {Julia L.}",
note = "Funding Information: We thank Virion Systems and Dr. Jorge Blanco (Sigmovir) for providing cotton rat antibody reagents. We thank Dr. John V. Williams (University of Pittsburgh) for the Cl. A1 MPV isolate. We thank Dr. Allen Portner for SeV-specific monoclonal antibodies generated at St. Jude. This work was supported by grants NIH NIAID P01 AI054955, NIH NIAID R01 AI088729, NIH NIAID R01 AI083370, NIH NCI P30-CA21765, and ALSAC. Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",
year = "2017",
month = sep,
doi = "10.1016/j.virol.2017.05.021",
language = "English",
volume = "509",
pages = "60--66",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
}
