A Sendai virus recombinant vaccine expressing a gene for truncated human metapneumovirus (hMPV) fusion protein protects cotton rats from hMPV challenge

Charles J. Russell, Bart G. Jones, Robert E. Sealy, Sherri L. Surman, John N. Mason, Randall T. Hayden, Ralph A. Tripp, Toru Takimoto, Julia L. Hurwitz

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Human metapneumovirus (hMPV) infections pose a serious health risk to young children, particularly in cases of premature birth. No licensed vaccine exists and there is no standard treatment for hMPV infections apart from supportive hospital care. We describe the production of a Sendai virus (SeV) recombinant that carries a gene for a truncated hMPV fusion (F) protein (SeV-MPV-Ft). The vaccine induces binding and neutralizing antibody responses toward hMPV and protection against challenge with hMPV in a cotton rat system. Results encourage advanced development of SeV-MPV-Ft to prevent the morbidity and mortality caused by hMPV infections in young children.

Original languageEnglish
Pages (from-to)60-66
Number of pages7
JournalVirology
Volume509
DOIs
Publication statusPublished - Sept 2017
Externally publishedYes

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