Acute and long-term effects of exposure to sodium monofluoroacetate (1080) in sheep

S. R. Gooneratne, C. T. Eason, L. Milne, D. G. Arthur, C. Cook, M. Wickstrom

Research output: Contribution to journalArticle

7 Citations (Scopus)
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Abstract

Acute and long-term effects of a single, relatively high oral dose (0.25 and 0.30 mg/kg) of sodium monofluoroacetate (1080) on the survival and productivity of sheep were evaluated to establish a better understanding of 1080 poisoning and identify more specific changes diagnostic of toxicosis. In survivors, clinical signs of acute 1080 toxicosis such as salivation and lethargy were generally very mild. Fasted animals were more prone to 1080 toxicity. In animals that died, more severe signs, including tachypnoea, dyspnoea, and tremors occurred for 15-20 min prior to death. 1080 concentrations were highest in the blood > heart > skeletal muscle > liver. 1080 could not be detected in any of these organs of the animals that survived. Serum citrate concentrations were elevated for 4 days after dosing. No clinical or biochemical abnormalities were found in any animal after 4 days. Histopathological lesions were most marked in the heart and lung with inflammation, necrosis, and scattered foci of fibrous tissue in the myocardium, pulmonary oedema and inflammation of the lung. No adverse long-term effects on general health or reproductive performance were observed in any sheep that survived the first 4 days following exposure to 1080. The most reliable diagnostic indicators of 1080 exposure in sheep were measurement of its residues in blood, skeletal muscle and ruminal contents, increased serum citrate concentration, elevated heart rate, and characteristic electrocardiograph changes (up to 4 days after exposure). Death from 1080 is most likely to occur within 96 h, and animals that survived this period appeared normal.

Original languageEnglish
Pages (from-to)127-139
Number of pages13
JournalOnderstepoort Journal of Veterinary Research
Volume75
Issue number2
DOIs
Publication statusPublished - 1 Jan 2008
Externally publishedYes

Fingerprint

long term effects
Sheep
Sodium
sodium
sheep
poisoning
lungs
blood serum
Citric Acid
citrates
skeletal muscle
Pneumonia
animals
Skeletal Muscle
inflammation
heart
death
Animal Structures
Salivation
Tachypnea

Cite this

Gooneratne, S. R., Eason, C. T., Milne, L., Arthur, D. G., Cook, C., & Wickstrom, M. (2008). Acute and long-term effects of exposure to sodium monofluoroacetate (1080) in sheep. Onderstepoort Journal of Veterinary Research, 75(2), 127-139. https://doi.org/10.4102/ojvr.v75i2.11
Gooneratne, S. R. ; Eason, C. T. ; Milne, L. ; Arthur, D. G. ; Cook, C. ; Wickstrom, M. / Acute and long-term effects of exposure to sodium monofluoroacetate (1080) in sheep. In: Onderstepoort Journal of Veterinary Research. 2008 ; Vol. 75, No. 2. pp. 127-139.
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Gooneratne, SR, Eason, CT, Milne, L, Arthur, DG, Cook, C & Wickstrom, M 2008, 'Acute and long-term effects of exposure to sodium monofluoroacetate (1080) in sheep', Onderstepoort Journal of Veterinary Research, vol. 75, no. 2, pp. 127-139. https://doi.org/10.4102/ojvr.v75i2.11

Acute and long-term effects of exposure to sodium monofluoroacetate (1080) in sheep. / Gooneratne, S. R.; Eason, C. T.; Milne, L.; Arthur, D. G.; Cook, C.; Wickstrom, M.

In: Onderstepoort Journal of Veterinary Research, Vol. 75, No. 2, 01.01.2008, p. 127-139.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Acute and long-term effects of exposure to sodium monofluoroacetate (1080) in sheep

AU - Gooneratne, S. R.

AU - Eason, C. T.

AU - Milne, L.

AU - Arthur, D. G.

AU - Cook, C.

AU - Wickstrom, M.

PY - 2008/1/1

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N2 - Acute and long-term effects of a single, relatively high oral dose (0.25 and 0.30 mg/kg) of sodium monofluoroacetate (1080) on the survival and productivity of sheep were evaluated to establish a better understanding of 1080 poisoning and identify more specific changes diagnostic of toxicosis. In survivors, clinical signs of acute 1080 toxicosis such as salivation and lethargy were generally very mild. Fasted animals were more prone to 1080 toxicity. In animals that died, more severe signs, including tachypnoea, dyspnoea, and tremors occurred for 15-20 min prior to death. 1080 concentrations were highest in the blood > heart > skeletal muscle > liver. 1080 could not be detected in any of these organs of the animals that survived. Serum citrate concentrations were elevated for 4 days after dosing. No clinical or biochemical abnormalities were found in any animal after 4 days. Histopathological lesions were most marked in the heart and lung with inflammation, necrosis, and scattered foci of fibrous tissue in the myocardium, pulmonary oedema and inflammation of the lung. No adverse long-term effects on general health or reproductive performance were observed in any sheep that survived the first 4 days following exposure to 1080. The most reliable diagnostic indicators of 1080 exposure in sheep were measurement of its residues in blood, skeletal muscle and ruminal contents, increased serum citrate concentration, elevated heart rate, and characteristic electrocardiograph changes (up to 4 days after exposure). Death from 1080 is most likely to occur within 96 h, and animals that survived this period appeared normal.

AB - Acute and long-term effects of a single, relatively high oral dose (0.25 and 0.30 mg/kg) of sodium monofluoroacetate (1080) on the survival and productivity of sheep were evaluated to establish a better understanding of 1080 poisoning and identify more specific changes diagnostic of toxicosis. In survivors, clinical signs of acute 1080 toxicosis such as salivation and lethargy were generally very mild. Fasted animals were more prone to 1080 toxicity. In animals that died, more severe signs, including tachypnoea, dyspnoea, and tremors occurred for 15-20 min prior to death. 1080 concentrations were highest in the blood > heart > skeletal muscle > liver. 1080 could not be detected in any of these organs of the animals that survived. Serum citrate concentrations were elevated for 4 days after dosing. No clinical or biochemical abnormalities were found in any animal after 4 days. Histopathological lesions were most marked in the heart and lung with inflammation, necrosis, and scattered foci of fibrous tissue in the myocardium, pulmonary oedema and inflammation of the lung. No adverse long-term effects on general health or reproductive performance were observed in any sheep that survived the first 4 days following exposure to 1080. The most reliable diagnostic indicators of 1080 exposure in sheep were measurement of its residues in blood, skeletal muscle and ruminal contents, increased serum citrate concentration, elevated heart rate, and characteristic electrocardiograph changes (up to 4 days after exposure). Death from 1080 is most likely to occur within 96 h, and animals that survived this period appeared normal.

KW - Cardiotoxicity

KW - Sheep

KW - Sodium monofluoroacetate

KW - Vertebrate pest control

U2 - 10.4102/ojvr.v75i2.11

DO - 10.4102/ojvr.v75i2.11

M3 - Article

VL - 75

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JF - The Onderstepoort journal of veterinary science and animal industry

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