Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletes

Andrew Govus, Chris Abbiss, Laura GARVICAN, Dorine Swinkles, Coby Laarakkers, Christopher Gore, Peter Peeling

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    Abstract

    Purpose This study measured the influence of acute hypoxic exercise on Interleukin-6 (IL-6), hepcidin, and iron biomarkers in athletes. Methods In a repeated measures design, 13 moderately trained endurance athletes performed 5 × 4 min intervals at 90 % of their peak oxygen consumption velocity (vVO2peak) in both normoxic [NORM, fraction of inspired oxygen (FIO2) = 0.2093, 15.3 ± 1.7 km h-1] and simulated hypoxic (HYP, FIO2 = 0.1450, 13.2 ± 1.5 km h-1) conditions. Venous blood samples were obtained pre-, post-, and 3 h post-exercise, and analysed for serum hepcidin, IL-6, ferritin, iron, soluble transferrin receptor (sTfR), and transferrin saturation. Results Peak heart rate was significantly lower in HYP compared with NORM (p = 0.01); however, the rating of perceived exertion was similar between trials (p = 0.24). Ferritin (p = 0.02), transferrin (p = 0.03), and IL-6 (p = 0.01) significantly increased immediately post-exercise in both conditions, but returned to baseline 3 h later. Hepcidin levels significantly increased in both conditions 3 h post-exercise (p = 0.05), with no significant differences between trials. A significant treatment effect was observed between trials for sTfR (p = 0.01), but not iron and transferrin saturation. Conclusion Acute exercise in hypoxia did not influence post-exercise IL-6 production, hepcidin activity or iron metabolism compared with exercise at the same relative intensity in normoxia. Hence, acute exercise performed at the same relative intensity in hypoxia poses no further risk to an athlete's iron status, as compared with exercise in normoxia.
    Original languageEnglish
    Pages (from-to)2183-2191
    Number of pages9
    JournalEuropean Journal of Applied Physiology
    Volume114
    Issue number10
    DOIs
    Publication statusPublished - 2014

    Fingerprint

    Athletes
    Iron
    Exercise
    Hepcidins
    Interleukin-6
    Transferrin
    Transferrin Receptors
    Ferritins
    Oxygen Consumption
    Biomarkers
    Heart Rate
    Oxygen
    Serum

    Cite this

    Govus, Andrew ; Abbiss, Chris ; GARVICAN, Laura ; Swinkles, Dorine ; Laarakkers, Coby ; Gore, Christopher ; Peeling, Peter. / Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletes. In: European Journal of Applied Physiology. 2014 ; Vol. 114, No. 10. pp. 2183-2191.
    @article{fe1b2cf3030f4f0bb4b6e93966fe2e3b,
    title = "Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletes",
    abstract = "Purpose This study measured the influence of acute hypoxic exercise on Interleukin-6 (IL-6), hepcidin, and iron biomarkers in athletes. Methods In a repeated measures design, 13 moderately trained endurance athletes performed 5 × 4 min intervals at 90 {\%} of their peak oxygen consumption velocity (vVO2peak) in both normoxic [NORM, fraction of inspired oxygen (FIO2) = 0.2093, 15.3 ± 1.7 km h-1] and simulated hypoxic (HYP, FIO2 = 0.1450, 13.2 ± 1.5 km h-1) conditions. Venous blood samples were obtained pre-, post-, and 3 h post-exercise, and analysed for serum hepcidin, IL-6, ferritin, iron, soluble transferrin receptor (sTfR), and transferrin saturation. Results Peak heart rate was significantly lower in HYP compared with NORM (p = 0.01); however, the rating of perceived exertion was similar between trials (p = 0.24). Ferritin (p = 0.02), transferrin (p = 0.03), and IL-6 (p = 0.01) significantly increased immediately post-exercise in both conditions, but returned to baseline 3 h later. Hepcidin levels significantly increased in both conditions 3 h post-exercise (p = 0.05), with no significant differences between trials. A significant treatment effect was observed between trials for sTfR (p = 0.01), but not iron and transferrin saturation. Conclusion Acute exercise in hypoxia did not influence post-exercise IL-6 production, hepcidin activity or iron metabolism compared with exercise at the same relative intensity in normoxia. Hence, acute exercise performed at the same relative intensity in hypoxia poses no further risk to an athlete's iron status, as compared with exercise in normoxia.",
    keywords = "Altitude training, Hepcidin, Intermittent hypoxic training, Iron deficiency",
    author = "Andrew Govus and Chris Abbiss and Laura GARVICAN and Dorine Swinkles and Coby Laarakkers and Christopher Gore and Peter Peeling",
    year = "2014",
    doi = "10.1007/s00421-014-2938-2",
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    Govus, A, Abbiss, C, GARVICAN, L, Swinkles, D, Laarakkers, C, Gore, C & Peeling, P 2014, 'Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletes', European Journal of Applied Physiology, vol. 114, no. 10, pp. 2183-2191. https://doi.org/10.1007/s00421-014-2938-2

    Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletes. / Govus, Andrew; Abbiss, Chris; GARVICAN, Laura; Swinkles, Dorine; Laarakkers, Coby; Gore, Christopher; Peeling, Peter.

    In: European Journal of Applied Physiology, Vol. 114, No. 10, 2014, p. 2183-2191.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletes

    AU - Govus, Andrew

    AU - Abbiss, Chris

    AU - GARVICAN, Laura

    AU - Swinkles, Dorine

    AU - Laarakkers, Coby

    AU - Gore, Christopher

    AU - Peeling, Peter

    PY - 2014

    Y1 - 2014

    N2 - Purpose This study measured the influence of acute hypoxic exercise on Interleukin-6 (IL-6), hepcidin, and iron biomarkers in athletes. Methods In a repeated measures design, 13 moderately trained endurance athletes performed 5 × 4 min intervals at 90 % of their peak oxygen consumption velocity (vVO2peak) in both normoxic [NORM, fraction of inspired oxygen (FIO2) = 0.2093, 15.3 ± 1.7 km h-1] and simulated hypoxic (HYP, FIO2 = 0.1450, 13.2 ± 1.5 km h-1) conditions. Venous blood samples were obtained pre-, post-, and 3 h post-exercise, and analysed for serum hepcidin, IL-6, ferritin, iron, soluble transferrin receptor (sTfR), and transferrin saturation. Results Peak heart rate was significantly lower in HYP compared with NORM (p = 0.01); however, the rating of perceived exertion was similar between trials (p = 0.24). Ferritin (p = 0.02), transferrin (p = 0.03), and IL-6 (p = 0.01) significantly increased immediately post-exercise in both conditions, but returned to baseline 3 h later. Hepcidin levels significantly increased in both conditions 3 h post-exercise (p = 0.05), with no significant differences between trials. A significant treatment effect was observed between trials for sTfR (p = 0.01), but not iron and transferrin saturation. Conclusion Acute exercise in hypoxia did not influence post-exercise IL-6 production, hepcidin activity or iron metabolism compared with exercise at the same relative intensity in normoxia. Hence, acute exercise performed at the same relative intensity in hypoxia poses no further risk to an athlete's iron status, as compared with exercise in normoxia.

    AB - Purpose This study measured the influence of acute hypoxic exercise on Interleukin-6 (IL-6), hepcidin, and iron biomarkers in athletes. Methods In a repeated measures design, 13 moderately trained endurance athletes performed 5 × 4 min intervals at 90 % of their peak oxygen consumption velocity (vVO2peak) in both normoxic [NORM, fraction of inspired oxygen (FIO2) = 0.2093, 15.3 ± 1.7 km h-1] and simulated hypoxic (HYP, FIO2 = 0.1450, 13.2 ± 1.5 km h-1) conditions. Venous blood samples were obtained pre-, post-, and 3 h post-exercise, and analysed for serum hepcidin, IL-6, ferritin, iron, soluble transferrin receptor (sTfR), and transferrin saturation. Results Peak heart rate was significantly lower in HYP compared with NORM (p = 0.01); however, the rating of perceived exertion was similar between trials (p = 0.24). Ferritin (p = 0.02), transferrin (p = 0.03), and IL-6 (p = 0.01) significantly increased immediately post-exercise in both conditions, but returned to baseline 3 h later. Hepcidin levels significantly increased in both conditions 3 h post-exercise (p = 0.05), with no significant differences between trials. A significant treatment effect was observed between trials for sTfR (p = 0.01), but not iron and transferrin saturation. Conclusion Acute exercise in hypoxia did not influence post-exercise IL-6 production, hepcidin activity or iron metabolism compared with exercise at the same relative intensity in normoxia. Hence, acute exercise performed at the same relative intensity in hypoxia poses no further risk to an athlete's iron status, as compared with exercise in normoxia.

    KW - Altitude training

    KW - Hepcidin

    KW - Intermittent hypoxic training

    KW - Iron deficiency

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    U2 - 10.1007/s00421-014-2938-2

    DO - 10.1007/s00421-014-2938-2

    M3 - Article

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    SP - 2183

    EP - 2191

    JO - European Journal of Applied Physiology and Occupational Physiology

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    SN - 1439-6319

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