Adaptation and conservation insights from the koala genome

Rebecca N. Johnson, Denis O’Meally, Zhiliang Chen, Graham J. Etherington, Simon Y.W. Ho, Will J. Nash, Catherine E. Grueber, Yuanyuan Cheng, Camilla M. Whittington, Siobhan Dennison, Emma Peel, Wilfried Haerty, Rachel J. O’Neill, Don Colgan, Tonia L. Russell, David E. Alquezar-Planas, Val Attenbrow, Jason G. Bragg, Parice A. Brandies, Amanda Yoon Yee Chong & 34 others Janine E. Deakin, Federica Di Palma, Zachary Duda, Mark D.B. Eldridge, Kyle M. Ewart, Carolyn J. Hogg, Greta J. Frankham, Arthur Georges, Amber K. Gillett, Merran Govendir, Alex D. Greenwood, Takashi Hayakawa, Kristofer M. Helgen, Matthew Hobbs, Clare E. Holleley, Thomas N. Heider, Elizabeth A. Jones, Andrew King, Danielle Madden, Jennifer A.Marshall Graves, Katrina M. Morris, Linda E. Neaves, Hardip R. Patel, Adam Polkinghorne, Marilyn B. Renfree, Charles Robin, Ryan Salinas, Kyriakos Tsangaras, Paul D. Waters, Shafagh A. Waters, Belinda Wright, Marc R. Wilkins, Peter Timms, Katherine Belov

    Research output: Contribution to journalArticle

    • 5 Citations

    Abstract

    The koala, the only extant species of the marsupial family Phascolarctidae, is classified as ‘vulnerable’ due to habitat loss and widespread disease. We sequenced the koala genome, producing a complete and contiguous marsupial reference genome, including centromeres. We reveal that the koala’s ability to detoxify eucalypt foliage may be due to expansions within a cytochrome P450 gene family, and its ability to smell, taste and moderate ingestion of plant secondary metabolites may be due to expansions in the vomeronasal and taste receptors. We characterized novel lactation proteins that protect young in the pouch and annotated immune genes important for response to chlamydial disease. Historical demography showed a substantial population crash coincident with the decline of Australian megafauna, while contemporary populations had biogeographic boundaries and increased inbreeding in populations affected by historic translocations. We identified genetically diverse populations that require habitat corridors and instituting of translocation programs to aid the koala’s survival in the wild.

    LanguageEnglish
    Pages1-10
    Number of pages10
    JournalNature Genetics
    DOIs
    StateAccepted/In press - 2 Jul 2018

    Fingerprint

    Phascolarctidae
    Genome
    Marsupialia
    Aptitude
    Population
    Ecosystem
    Inbreeding
    Smell
    Centromere
    Lactation
    Cytochrome P-450 Enzyme System
    Genes
    Eating
    Demography
    Proteins

    Cite this

    Johnson, R. N., O’Meally, D., Chen, Z., Etherington, G. J., Ho, S. Y. W., Nash, W. J., ... Belov, K. (Accepted/In press). Adaptation and conservation insights from the koala genome. Nature Genetics, 1-10. DOI: 10.1038/s41588-018-0153-5
    Johnson, Rebecca N. ; O’Meally, Denis ; Chen, Zhiliang ; Etherington, Graham J. ; Ho, Simon Y.W. ; Nash, Will J. ; Grueber, Catherine E. ; Cheng, Yuanyuan ; Whittington, Camilla M. ; Dennison, Siobhan ; Peel, Emma ; Haerty, Wilfried ; O’Neill, Rachel J. ; Colgan, Don ; Russell, Tonia L. ; Alquezar-Planas, David E. ; Attenbrow, Val ; Bragg, Jason G. ; Brandies, Parice A. ; Chong, Amanda Yoon Yee ; Deakin, Janine E. ; Di Palma, Federica ; Duda, Zachary ; Eldridge, Mark D.B. ; Ewart, Kyle M. ; Hogg, Carolyn J. ; Frankham, Greta J. ; Georges, Arthur ; Gillett, Amber K. ; Govendir, Merran ; Greenwood, Alex D. ; Hayakawa, Takashi ; Helgen, Kristofer M. ; Hobbs, Matthew ; Holleley, Clare E. ; Heider, Thomas N. ; Jones, Elizabeth A. ; King, Andrew ; Madden, Danielle ; Graves, Jennifer A.Marshall ; Morris, Katrina M. ; Neaves, Linda E. ; Patel, Hardip R. ; Polkinghorne, Adam ; Renfree, Marilyn B. ; Robin, Charles ; Salinas, Ryan ; Tsangaras, Kyriakos ; Waters, Paul D. ; Waters, Shafagh A. ; Wright, Belinda ; Wilkins, Marc R. ; Timms, Peter ; Belov, Katherine. / Adaptation and conservation insights from the koala genome. In: Nature Genetics. 2018 ; pp. 1-10
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    abstract = "The koala, the only extant species of the marsupial family Phascolarctidae, is classified as ‘vulnerable’ due to habitat loss and widespread disease. We sequenced the koala genome, producing a complete and contiguous marsupial reference genome, including centromeres. We reveal that the koala’s ability to detoxify eucalypt foliage may be due to expansions within a cytochrome P450 gene family, and its ability to smell, taste and moderate ingestion of plant secondary metabolites may be due to expansions in the vomeronasal and taste receptors. We characterized novel lactation proteins that protect young in the pouch and annotated immune genes important for response to chlamydial disease. Historical demography showed a substantial population crash coincident with the decline of Australian megafauna, while contemporary populations had biogeographic boundaries and increased inbreeding in populations affected by historic translocations. We identified genetically diverse populations that require habitat corridors and instituting of translocation programs to aid the koala’s survival in the wild.",
    author = "Johnson, {Rebecca N.} and Denis O’Meally and Zhiliang Chen and Etherington, {Graham J.} and Ho, {Simon Y.W.} and Nash, {Will J.} and Grueber, {Catherine E.} and Yuanyuan Cheng and Whittington, {Camilla M.} and Siobhan Dennison and Emma Peel and Wilfried Haerty and O’Neill, {Rachel J.} and Don Colgan and Russell, {Tonia L.} and Alquezar-Planas, {David E.} and Val Attenbrow and Bragg, {Jason G.} and Brandies, {Parice A.} and Chong, {Amanda Yoon Yee} and Deakin, {Janine E.} and {Di Palma}, Federica and Zachary Duda and Eldridge, {Mark D.B.} and Ewart, {Kyle M.} and Hogg, {Carolyn J.} and Frankham, {Greta J.} and Arthur Georges and Gillett, {Amber K.} and Merran Govendir and Greenwood, {Alex D.} and Takashi Hayakawa and Helgen, {Kristofer M.} and Matthew Hobbs and Holleley, {Clare E.} and Heider, {Thomas N.} and Jones, {Elizabeth A.} and Andrew King and Danielle Madden and Graves, {Jennifer A.Marshall} and Morris, {Katrina M.} and Neaves, {Linda E.} and Patel, {Hardip R.} and Adam Polkinghorne and Renfree, {Marilyn B.} and Charles Robin and Ryan Salinas and Kyriakos Tsangaras and Waters, {Paul D.} and Waters, {Shafagh A.} and Belinda Wright and Wilkins, {Marc R.} and Peter Timms and Katherine Belov",
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    Johnson, RN, O’Meally, D, Chen, Z, Etherington, GJ, Ho, SYW, Nash, WJ, Grueber, CE, Cheng, Y, Whittington, CM, Dennison, S, Peel, E, Haerty, W, O’Neill, RJ, Colgan, D, Russell, TL, Alquezar-Planas, DE, Attenbrow, V, Bragg, JG, Brandies, PA, Chong, AYY, Deakin, JE, Di Palma, F, Duda, Z, Eldridge, MDB, Ewart, KM, Hogg, CJ, Frankham, GJ, Georges, A, Gillett, AK, Govendir, M, Greenwood, AD, Hayakawa, T, Helgen, KM, Hobbs, M, Holleley, CE, Heider, TN, Jones, EA, King, A, Madden, D, Graves, JAM, Morris, KM, Neaves, LE, Patel, HR, Polkinghorne, A, Renfree, MB, Robin, C, Salinas, R, Tsangaras, K, Waters, PD, Waters, SA, Wright, B, Wilkins, MR, Timms, P & Belov, K 2018, 'Adaptation and conservation insights from the koala genome' Nature Genetics, pp. 1-10. DOI: 10.1038/s41588-018-0153-5

    Adaptation and conservation insights from the koala genome. / Johnson, Rebecca N.; O’Meally, Denis; Chen, Zhiliang; Etherington, Graham J.; Ho, Simon Y.W.; Nash, Will J.; Grueber, Catherine E.; Cheng, Yuanyuan; Whittington, Camilla M.; Dennison, Siobhan; Peel, Emma; Haerty, Wilfried; O’Neill, Rachel J.; Colgan, Don; Russell, Tonia L.; Alquezar-Planas, David E.; Attenbrow, Val; Bragg, Jason G.; Brandies, Parice A.; Chong, Amanda Yoon Yee; Deakin, Janine E.; Di Palma, Federica; Duda, Zachary; Eldridge, Mark D.B.; Ewart, Kyle M.; Hogg, Carolyn J.; Frankham, Greta J.; Georges, Arthur; Gillett, Amber K.; Govendir, Merran; Greenwood, Alex D.; Hayakawa, Takashi; Helgen, Kristofer M.; Hobbs, Matthew; Holleley, Clare E.; Heider, Thomas N.; Jones, Elizabeth A.; King, Andrew; Madden, Danielle; Graves, Jennifer A.Marshall; Morris, Katrina M.; Neaves, Linda E.; Patel, Hardip R.; Polkinghorne, Adam; Renfree, Marilyn B.; Robin, Charles; Salinas, Ryan; Tsangaras, Kyriakos; Waters, Paul D.; Waters, Shafagh A.; Wright, Belinda; Wilkins, Marc R.; Timms, Peter; Belov, Katherine.

    In: Nature Genetics, 02.07.2018, p. 1-10.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Adaptation and conservation insights from the koala genome

    AU - Johnson,Rebecca N.

    AU - O’Meally,Denis

    AU - Chen,Zhiliang

    AU - Etherington,Graham J.

    AU - Ho,Simon Y.W.

    AU - Nash,Will J.

    AU - Grueber,Catherine E.

    AU - Cheng,Yuanyuan

    AU - Whittington,Camilla M.

    AU - Dennison,Siobhan

    AU - Peel,Emma

    AU - Haerty,Wilfried

    AU - O’Neill,Rachel J.

    AU - Colgan,Don

    AU - Russell,Tonia L.

    AU - Alquezar-Planas,David E.

    AU - Attenbrow,Val

    AU - Bragg,Jason G.

    AU - Brandies,Parice A.

    AU - Chong,Amanda Yoon Yee

    AU - Deakin,Janine E.

    AU - Di Palma,Federica

    AU - Duda,Zachary

    AU - Eldridge,Mark D.B.

    AU - Ewart,Kyle M.

    AU - Hogg,Carolyn J.

    AU - Frankham,Greta J.

    AU - Georges,Arthur

    AU - Gillett,Amber K.

    AU - Govendir,Merran

    AU - Greenwood,Alex D.

    AU - Hayakawa,Takashi

    AU - Helgen,Kristofer M.

    AU - Hobbs,Matthew

    AU - Holleley,Clare E.

    AU - Heider,Thomas N.

    AU - Jones,Elizabeth A.

    AU - King,Andrew

    AU - Madden,Danielle

    AU - Graves,Jennifer A.Marshall

    AU - Morris,Katrina M.

    AU - Neaves,Linda E.

    AU - Patel,Hardip R.

    AU - Polkinghorne,Adam

    AU - Renfree,Marilyn B.

    AU - Robin,Charles

    AU - Salinas,Ryan

    AU - Tsangaras,Kyriakos

    AU - Waters,Paul D.

    AU - Waters,Shafagh A.

    AU - Wright,Belinda

    AU - Wilkins,Marc R.

    AU - Timms,Peter

    AU - Belov,Katherine

    PY - 2018/7/2

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    Johnson RN, O’Meally D, Chen Z, Etherington GJ, Ho SYW, Nash WJ et al. Adaptation and conservation insights from the koala genome. Nature Genetics. 2018 Jul 2;1-10. Available from, DOI: 10.1038/s41588-018-0153-5