Adaptation and conservation insights from the koala genome

Rebecca N. Johnson, Denis O’Meally, Zhiliang Chen, Graham J. Etherington, Simon Y.W. Ho, Will J. Nash, Catherine E. Grueber, Yuanyuan Cheng, Camilla M. Whittington, Siobhan Dennison, Emma Peel, Wilfried Haerty, Rachel J. O’Neill, Don Colgan, Tonia L. Russell, David E. Alquezar-Planas, Val Attenbrow, Jason G. Bragg, Parice A. Brandies, Amanda Yoon Yee Chong & 34 others Janine E. Deakin, Federica Di Palma, Zachary Duda, Mark D.B. Eldridge, Kyle M. Ewart, Carolyn J. Hogg, Greta J. Frankham, Arthur Georges, Amber K. Gillett, Merran Govendir, Alex D. Greenwood, Takashi Hayakawa, Kristofer M. Helgen, Matthew Hobbs, Clare E. Holleley, Thomas N. Heider, Elizabeth A. Jones, Andrew King, Danielle Madden, Jennifer A.Marshall Graves, Katrina M. Morris, Linda E. Neaves, Hardip R. Patel, Adam Polkinghorne, Marilyn B. Renfree, Charles Robin, Ryan Salinas, Kyriakos Tsangaras, Paul D. Waters, Shafagh A. Waters, Belinda Wright, Marc R. Wilkins, Peter Timms, Katherine Belov

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The koala, the only extant species of the marsupial family Phascolarctidae, is classified as ‘vulnerable’ due to habitat loss and widespread disease. We sequenced the koala genome, producing a complete and contiguous marsupial reference genome, including centromeres. We reveal that the koala’s ability to detoxify eucalypt foliage may be due to expansions within a cytochrome P450 gene family, and its ability to smell, taste and moderate ingestion of plant secondary metabolites may be due to expansions in the vomeronasal and taste receptors. We characterized novel lactation proteins that protect young in the pouch and annotated immune genes important for response to chlamydial disease. Historical demography showed a substantial population crash coincident with the decline of Australian megafauna, while contemporary populations had biogeographic boundaries and increased inbreeding in populations affected by historic translocations. We identified genetically diverse populations that require habitat corridors and instituting of translocation programs to aid the koala’s survival in the wild.

Original languageEnglish
Pages (from-to)1102-1111
Number of pages10
JournalNature Genetics
Volume50
Issue number8
DOIs
Publication statusPublished - Aug 2018

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Phascolarctidae
Genome
Marsupialia
Aptitude
Population
Ecosystem
Inbreeding
Smell
Centromere
Lactation
Cytochrome P-450 Enzyme System
Genes
Eating
Demography
Proteins

Cite this

Johnson, R. N., O’Meally, D., Chen, Z., Etherington, G. J., Ho, S. Y. W., Nash, W. J., ... Belov, K. (2018). Adaptation and conservation insights from the koala genome. Nature Genetics, 50(8), 1102-1111. https://doi.org/10.1038/s41588-018-0153-5
Johnson, Rebecca N. ; O’Meally, Denis ; Chen, Zhiliang ; Etherington, Graham J. ; Ho, Simon Y.W. ; Nash, Will J. ; Grueber, Catherine E. ; Cheng, Yuanyuan ; Whittington, Camilla M. ; Dennison, Siobhan ; Peel, Emma ; Haerty, Wilfried ; O’Neill, Rachel J. ; Colgan, Don ; Russell, Tonia L. ; Alquezar-Planas, David E. ; Attenbrow, Val ; Bragg, Jason G. ; Brandies, Parice A. ; Chong, Amanda Yoon Yee ; Deakin, Janine E. ; Di Palma, Federica ; Duda, Zachary ; Eldridge, Mark D.B. ; Ewart, Kyle M. ; Hogg, Carolyn J. ; Frankham, Greta J. ; Georges, Arthur ; Gillett, Amber K. ; Govendir, Merran ; Greenwood, Alex D. ; Hayakawa, Takashi ; Helgen, Kristofer M. ; Hobbs, Matthew ; Holleley, Clare E. ; Heider, Thomas N. ; Jones, Elizabeth A. ; King, Andrew ; Madden, Danielle ; Graves, Jennifer A.Marshall ; Morris, Katrina M. ; Neaves, Linda E. ; Patel, Hardip R. ; Polkinghorne, Adam ; Renfree, Marilyn B. ; Robin, Charles ; Salinas, Ryan ; Tsangaras, Kyriakos ; Waters, Paul D. ; Waters, Shafagh A. ; Wright, Belinda ; Wilkins, Marc R. ; Timms, Peter ; Belov, Katherine. / Adaptation and conservation insights from the koala genome. In: Nature Genetics. 2018 ; Vol. 50, No. 8. pp. 1102-1111.
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Johnson, RN, O’Meally, D, Chen, Z, Etherington, GJ, Ho, SYW, Nash, WJ, Grueber, CE, Cheng, Y, Whittington, CM, Dennison, S, Peel, E, Haerty, W, O’Neill, RJ, Colgan, D, Russell, TL, Alquezar-Planas, DE, Attenbrow, V, Bragg, JG, Brandies, PA, Chong, AYY, Deakin, JE, Di Palma, F, Duda, Z, Eldridge, MDB, Ewart, KM, Hogg, CJ, Frankham, GJ, Georges, A, Gillett, AK, Govendir, M, Greenwood, AD, Hayakawa, T, Helgen, KM, Hobbs, M, Holleley, CE, Heider, TN, Jones, EA, King, A, Madden, D, Graves, JAM, Morris, KM, Neaves, LE, Patel, HR, Polkinghorne, A, Renfree, MB, Robin, C, Salinas, R, Tsangaras, K, Waters, PD, Waters, SA, Wright, B, Wilkins, MR, Timms, P & Belov, K 2018, 'Adaptation and conservation insights from the koala genome', Nature Genetics, vol. 50, no. 8, pp. 1102-1111. https://doi.org/10.1038/s41588-018-0153-5

Adaptation and conservation insights from the koala genome. / Johnson, Rebecca N.; O’Meally, Denis; Chen, Zhiliang; Etherington, Graham J.; Ho, Simon Y.W.; Nash, Will J.; Grueber, Catherine E.; Cheng, Yuanyuan; Whittington, Camilla M.; Dennison, Siobhan; Peel, Emma; Haerty, Wilfried; O’Neill, Rachel J.; Colgan, Don; Russell, Tonia L.; Alquezar-Planas, David E.; Attenbrow, Val; Bragg, Jason G.; Brandies, Parice A.; Chong, Amanda Yoon Yee; Deakin, Janine E.; Di Palma, Federica; Duda, Zachary; Eldridge, Mark D.B.; Ewart, Kyle M.; Hogg, Carolyn J.; Frankham, Greta J.; Georges, Arthur; Gillett, Amber K.; Govendir, Merran; Greenwood, Alex D.; Hayakawa, Takashi; Helgen, Kristofer M.; Hobbs, Matthew; Holleley, Clare E.; Heider, Thomas N.; Jones, Elizabeth A.; King, Andrew; Madden, Danielle; Graves, Jennifer A.Marshall; Morris, Katrina M.; Neaves, Linda E.; Patel, Hardip R.; Polkinghorne, Adam; Renfree, Marilyn B.; Robin, Charles; Salinas, Ryan; Tsangaras, Kyriakos; Waters, Paul D.; Waters, Shafagh A.; Wright, Belinda; Wilkins, Marc R.; Timms, Peter; Belov, Katherine.

In: Nature Genetics, Vol. 50, No. 8, 08.2018, p. 1102-1111.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Adaptation and conservation insights from the koala genome

AU - Johnson, Rebecca N.

AU - O’Meally, Denis

AU - Chen, Zhiliang

AU - Etherington, Graham J.

AU - Ho, Simon Y.W.

AU - Nash, Will J.

AU - Grueber, Catherine E.

AU - Cheng, Yuanyuan

AU - Whittington, Camilla M.

AU - Dennison, Siobhan

AU - Peel, Emma

AU - Haerty, Wilfried

AU - O’Neill, Rachel J.

AU - Colgan, Don

AU - Russell, Tonia L.

AU - Alquezar-Planas, David E.

AU - Attenbrow, Val

AU - Bragg, Jason G.

AU - Brandies, Parice A.

AU - Chong, Amanda Yoon Yee

AU - Deakin, Janine E.

AU - Di Palma, Federica

AU - Duda, Zachary

AU - Eldridge, Mark D.B.

AU - Ewart, Kyle M.

AU - Hogg, Carolyn J.

AU - Frankham, Greta J.

AU - Georges, Arthur

AU - Gillett, Amber K.

AU - Govendir, Merran

AU - Greenwood, Alex D.

AU - Hayakawa, Takashi

AU - Helgen, Kristofer M.

AU - Hobbs, Matthew

AU - Holleley, Clare E.

AU - Heider, Thomas N.

AU - Jones, Elizabeth A.

AU - King, Andrew

AU - Madden, Danielle

AU - Graves, Jennifer A.Marshall

AU - Morris, Katrina M.

AU - Neaves, Linda E.

AU - Patel, Hardip R.

AU - Polkinghorne, Adam

AU - Renfree, Marilyn B.

AU - Robin, Charles

AU - Salinas, Ryan

AU - Tsangaras, Kyriakos

AU - Waters, Paul D.

AU - Waters, Shafagh A.

AU - Wright, Belinda

AU - Wilkins, Marc R.

AU - Timms, Peter

AU - Belov, Katherine

PY - 2018/8

Y1 - 2018/8

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KW - Animals

KW - Australia

KW - Chlamydia Infections/genetics

KW - Cytochrome P-450 Enzyme System/genetics

KW - Female

KW - Genome

KW - Molecular Sequence Annotation/methods

KW - Phascolarctidae/genetics

KW - Translocation, Genetic

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Johnson RN, O’Meally D, Chen Z, Etherington GJ, Ho SYW, Nash WJ et al. Adaptation and conservation insights from the koala genome. Nature Genetics. 2018 Aug;50(8):1102-1111. https://doi.org/10.1038/s41588-018-0153-5