Altitude Exposure at 1800 m Increases Haemoglobin Mass in Distance Runners

Laura GARVICAN, Iona Halliday, Chris Abbiss, Philo Saunders, Christopher Gore

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    The influence of low natural altitudes (<2000 m) on erythropoietic adaptation is currently unclear, with current recommendations indicating that such low altitudes may be insufficient to stimulate significant increases in haemoglobin mass (Hb mass). As such, the purpose of this study was to determine the influence of 3 weeks of live high, train high exposure (LHTH) at low natural altitude (i.e. 1800 m) on Hb mass, red blood cell count and iron profile. A total of 16 elite or well-trained runners were assigned into either a LHTH (n = 8) or CONTROL (n = 8) group. Venous blood samples were drawn prior to, at 2 weeks and at 3 weeks following exposure. Hb mass was measured in duplicate prior to exposure and at 2 weeks and at 3 weeks following exposure via carbon monoxide rebreathing. The percentage change in Hb mass from baseline was significantly greater in LHTH, when compared with the CONTROL group at 2 (3.1% vs 0.4%; p = 0.01;) and 3 weeks (3.0% vs -1.1%; p <0.02, respectively) following exposure. Haematocrit was greater in LHTH than CONTROL at 2 (p = 0.01) and 3 weeks (p = 0.04) following exposure. No significant interaction effect was observed for haemoglobin concentration (p = 0.06), serum ferritin (p = 0.43), transferrin (p = 0.52) or reticulocyte percentage (p = 0.16). The results of this study indicate that three week of natural classic (i.e. LHTH) low altitude exposure (1800 m) results in a significant increase in Hb mass of elite distance runners, which is likely due to the continuous exposure to hypoxia
    Original languageEnglish
    Pages (from-to)413-417
    Number of pages5
    JournalJournal of Sports Science and Medicine
    Volume14
    Issue number2
    Publication statusPublished - 2015

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    Hemoglobins
    Erythrocyte Count
    Reticulocytes
    Carbon Monoxide
    Transferrin
    Ferritins
    Hematocrit
    Iron
    Serum

    Cite this

    GARVICAN, L., Halliday, I., Abbiss, C., Saunders, P., & Gore, C. (2015). Altitude Exposure at 1800 m Increases Haemoglobin Mass in Distance Runners. Journal of Sports Science and Medicine, 14(2), 413-417.
    GARVICAN, Laura ; Halliday, Iona ; Abbiss, Chris ; Saunders, Philo ; Gore, Christopher. / Altitude Exposure at 1800 m Increases Haemoglobin Mass in Distance Runners. In: Journal of Sports Science and Medicine. 2015 ; Vol. 14, No. 2. pp. 413-417.
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    title = "Altitude Exposure at 1800 m Increases Haemoglobin Mass in Distance Runners",
    abstract = "The influence of low natural altitudes (<2000 m) on erythropoietic adaptation is currently unclear, with current recommendations indicating that such low altitudes may be insufficient to stimulate significant increases in haemoglobin mass (Hb mass). As such, the purpose of this study was to determine the influence of 3 weeks of live high, train high exposure (LHTH) at low natural altitude (i.e. 1800 m) on Hb mass, red blood cell count and iron profile. A total of 16 elite or well-trained runners were assigned into either a LHTH (n = 8) or CONTROL (n = 8) group. Venous blood samples were drawn prior to, at 2 weeks and at 3 weeks following exposure. Hb mass was measured in duplicate prior to exposure and at 2 weeks and at 3 weeks following exposure via carbon monoxide rebreathing. The percentage change in Hb mass from baseline was significantly greater in LHTH, when compared with the CONTROL group at 2 (3.1{\%} vs 0.4{\%}; p = 0.01;) and 3 weeks (3.0{\%} vs -1.1{\%}; p <0.02, respectively) following exposure. Haematocrit was greater in LHTH than CONTROL at 2 (p = 0.01) and 3 weeks (p = 0.04) following exposure. No significant interaction effect was observed for haemoglobin concentration (p = 0.06), serum ferritin (p = 0.43), transferrin (p = 0.52) or reticulocyte percentage (p = 0.16). The results of this study indicate that three week of natural classic (i.e. LHTH) low altitude exposure (1800 m) results in a significant increase in Hb mass of elite distance runners, which is likely due to the continuous exposure to hypoxia",
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    author = "Laura GARVICAN and Iona Halliday and Chris Abbiss and Philo Saunders and Christopher Gore",
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    GARVICAN, L, Halliday, I, Abbiss, C, Saunders, P & Gore, C 2015, 'Altitude Exposure at 1800 m Increases Haemoglobin Mass in Distance Runners', Journal of Sports Science and Medicine, vol. 14, no. 2, pp. 413-417.

    Altitude Exposure at 1800 m Increases Haemoglobin Mass in Distance Runners. / GARVICAN, Laura; Halliday, Iona; Abbiss, Chris; Saunders, Philo; Gore, Christopher.

    In: Journal of Sports Science and Medicine, Vol. 14, No. 2, 2015, p. 413-417.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Altitude Exposure at 1800 m Increases Haemoglobin Mass in Distance Runners

    AU - GARVICAN, Laura

    AU - Halliday, Iona

    AU - Abbiss, Chris

    AU - Saunders, Philo

    AU - Gore, Christopher

    PY - 2015

    Y1 - 2015

    N2 - The influence of low natural altitudes (<2000 m) on erythropoietic adaptation is currently unclear, with current recommendations indicating that such low altitudes may be insufficient to stimulate significant increases in haemoglobin mass (Hb mass). As such, the purpose of this study was to determine the influence of 3 weeks of live high, train high exposure (LHTH) at low natural altitude (i.e. 1800 m) on Hb mass, red blood cell count and iron profile. A total of 16 elite or well-trained runners were assigned into either a LHTH (n = 8) or CONTROL (n = 8) group. Venous blood samples were drawn prior to, at 2 weeks and at 3 weeks following exposure. Hb mass was measured in duplicate prior to exposure and at 2 weeks and at 3 weeks following exposure via carbon monoxide rebreathing. The percentage change in Hb mass from baseline was significantly greater in LHTH, when compared with the CONTROL group at 2 (3.1% vs 0.4%; p = 0.01;) and 3 weeks (3.0% vs -1.1%; p <0.02, respectively) following exposure. Haematocrit was greater in LHTH than CONTROL at 2 (p = 0.01) and 3 weeks (p = 0.04) following exposure. No significant interaction effect was observed for haemoglobin concentration (p = 0.06), serum ferritin (p = 0.43), transferrin (p = 0.52) or reticulocyte percentage (p = 0.16). The results of this study indicate that three week of natural classic (i.e. LHTH) low altitude exposure (1800 m) results in a significant increase in Hb mass of elite distance runners, which is likely due to the continuous exposure to hypoxia

    AB - The influence of low natural altitudes (<2000 m) on erythropoietic adaptation is currently unclear, with current recommendations indicating that such low altitudes may be insufficient to stimulate significant increases in haemoglobin mass (Hb mass). As such, the purpose of this study was to determine the influence of 3 weeks of live high, train high exposure (LHTH) at low natural altitude (i.e. 1800 m) on Hb mass, red blood cell count and iron profile. A total of 16 elite or well-trained runners were assigned into either a LHTH (n = 8) or CONTROL (n = 8) group. Venous blood samples were drawn prior to, at 2 weeks and at 3 weeks following exposure. Hb mass was measured in duplicate prior to exposure and at 2 weeks and at 3 weeks following exposure via carbon monoxide rebreathing. The percentage change in Hb mass from baseline was significantly greater in LHTH, when compared with the CONTROL group at 2 (3.1% vs 0.4%; p = 0.01;) and 3 weeks (3.0% vs -1.1%; p <0.02, respectively) following exposure. Haematocrit was greater in LHTH than CONTROL at 2 (p = 0.01) and 3 weeks (p = 0.04) following exposure. No significant interaction effect was observed for haemoglobin concentration (p = 0.06), serum ferritin (p = 0.43), transferrin (p = 0.52) or reticulocyte percentage (p = 0.16). The results of this study indicate that three week of natural classic (i.e. LHTH) low altitude exposure (1800 m) results in a significant increase in Hb mass of elite distance runners, which is likely due to the continuous exposure to hypoxia

    KW - Erythropoiesis

    KW - Hypoxia

    KW - Hypoxic dose

    KW - LHTH

    M3 - Article

    VL - 14

    SP - 413

    EP - 417

    JO - Journal of Sports Science and Medicine

    JF - Journal of Sports Science and Medicine

    SN - 1303-2968

    IS - 2

    ER -

    GARVICAN L, Halliday I, Abbiss C, Saunders P, Gore C. Altitude Exposure at 1800 m Increases Haemoglobin Mass in Distance Runners. Journal of Sports Science and Medicine. 2015;14(2):413-417.