Amygdala subnuclei volumes, functional connectivity and social–emotional outcomes in children born very preterm

Study Group For The Piano

doi:10.1093/texcom/tgac028

Amygdala subnuclei volumes, functional connectivity and social–emotional outcomes in children born very preterm

Study Group For The Piano

Optometry and Vision Science

Research output: Contribution to journal › Article › peer-review

57 Downloads (Pure)

Abstract

Children born very preterm can demonstrate social-cognitive impairments, which may result from limbic system dysfunction. Altered development of the subnuclei of the amygdala, stress-sensitive regions involved in emotional processing, may be a key predictor of social-skill development.

In a prospective cohort study, 7-year-old children born very preterm underwent neurodevelopmental testing and brain MRI. The Child Behavioral Checklist (CBCL) was used to assess social–emotional outcomes. Subnuclei volumes were extracted automatically from structural scans (n = 69) and functional connectivity (n = 66) was examined. General Linear Models were employed to examine the relationships between amygdala subnuclei volumes and functional connectivity values and social–emotional outcomes.

Sex was a significant predictor of all social–emotional outcomes (P
Dysregulated maturation of the amygdala subnuclei, along with altered connectivity strength in stress-sensitive regions, may reflect stress-induced dysfunction and can be predictive of social–emotional outcomes.

Original language	English
Pages (from-to)	1-19
Number of pages	19
Journal	Cerebral Cortex Communications
DOIs	https://doi.org/10.1093/texcom/tgac028
Publication status	Published - 22 Jul 2022

Access to Document

10.1093/texcom/tgac028Licence: CC BY

ArticleFinal published version, 479 KBLicence: CC BY

Cite this

@article{d21f592965e243abb32c328535a12403,

title = "Amygdala subnuclei volumes, functional connectivity and social–emotional outcomes in children born very preterm",

abstract = "Children born very preterm can demonstrate social-cognitive impairments, which may result from limbic system dysfunction. Altered development of the subnuclei of the amygdala, stress-sensitive regions involved in emotional processing, may be a key predictor of social-skill development.In a prospective cohort study, 7-year-old children born very preterm underwent neurodevelopmental testing and brain MRI. The Child Behavioral Checklist (CBCL) was used to assess social–emotional outcomes. Subnuclei volumes were extracted automatically from structural scans (n = 69) and functional connectivity (n = 66) was examined. General Linear Models were employed to examine the relationships between amygdala subnuclei volumes and functional connectivity values and social–emotional outcomes.Sex was a significant predictor of all social–emotional outcomes (P Dysregulated maturation of the amygdala subnuclei, along with altered connectivity strength in stress-sensitive regions, may reflect stress-induced dysfunction and can be predictive of social–emotional outcomes.",

author = "{Study Group For The Piano} and Megan Mueller and Benjamin Thompson and Tanya Poppe and Jane Alsweiler and Greg Gamble and Yannan Jiang and Myra Leung and Tottman, {Anna C} and Trecia Wouldes and Harding, {Jane E} and Duerden, {Emma G}",

year = "2022",

month = jul,

day = "22",

doi = "10.1093/texcom/tgac028",

language = "English",

pages = "1--19",

journal = "Cerebral Cortex Communications",

issn = "2632-7376",

}

TY - JOUR

T1 - Amygdala subnuclei volumes, functional connectivity and social–emotional outcomes in children born very preterm

AU - Study Group For The Piano

AU - Mueller, Megan

AU - Thompson, Benjamin

AU - Poppe, Tanya

AU - Alsweiler, Jane

AU - Gamble, Greg

AU - Jiang, Yannan

AU - Leung, Myra

AU - Tottman, Anna C

AU - Wouldes, Trecia

AU - Harding, Jane E

AU - Duerden, Emma G

PY - 2022/7/22

Y1 - 2022/7/22

N2 - Children born very preterm can demonstrate social-cognitive impairments, which may result from limbic system dysfunction. Altered development of the subnuclei of the amygdala, stress-sensitive regions involved in emotional processing, may be a key predictor of social-skill development.In a prospective cohort study, 7-year-old children born very preterm underwent neurodevelopmental testing and brain MRI. The Child Behavioral Checklist (CBCL) was used to assess social–emotional outcomes. Subnuclei volumes were extracted automatically from structural scans (n = 69) and functional connectivity (n = 66) was examined. General Linear Models were employed to examine the relationships between amygdala subnuclei volumes and functional connectivity values and social–emotional outcomes.Sex was a significant predictor of all social–emotional outcomes (P Dysregulated maturation of the amygdala subnuclei, along with altered connectivity strength in stress-sensitive regions, may reflect stress-induced dysfunction and can be predictive of social–emotional outcomes.

AB - Children born very preterm can demonstrate social-cognitive impairments, which may result from limbic system dysfunction. Altered development of the subnuclei of the amygdala, stress-sensitive regions involved in emotional processing, may be a key predictor of social-skill development.In a prospective cohort study, 7-year-old children born very preterm underwent neurodevelopmental testing and brain MRI. The Child Behavioral Checklist (CBCL) was used to assess social–emotional outcomes. Subnuclei volumes were extracted automatically from structural scans (n = 69) and functional connectivity (n = 66) was examined. General Linear Models were employed to examine the relationships between amygdala subnuclei volumes and functional connectivity values and social–emotional outcomes.Sex was a significant predictor of all social–emotional outcomes (P Dysregulated maturation of the amygdala subnuclei, along with altered connectivity strength in stress-sensitive regions, may reflect stress-induced dysfunction and can be predictive of social–emotional outcomes.

U2 - 10.1093/texcom/tgac028

DO - 10.1093/texcom/tgac028

M3 - Article

SN - 2632-7376

SP - 1

EP - 19

JO - Cerebral Cortex Communications

JF - Cerebral Cortex Communications

ER -

Amygdala subnuclei volumes, functional connectivity and social–emotional outcomes in children born very preterm

Abstract

Access to Document

Fingerprint

Cite this