An insight into chiral monolithic stationary phases for enantioselective high-performance liquid chromatography applications

Ali Fouad, Diana Ibrahim, Frady G. Adly, Ashraf Ghanem

Research output: Contribution to journalReview article

1 Citation (Scopus)


In this review, three main classes of chiral monolithic stationary phases, namely silica-, organic polymer-, and hybrid-based monolithic stationary phases, are covered. Their preparations, applications, and advantages compared with the conventional-packed and open-tubular capillary columns are discussed. A detailed description of the different types and techniques used for the introduction of chiral selectors into the monolithic matrices such as immobilization, functionalization, coating, encapsulation, and bonding. Special emphasis is given to the recent developments of chiral selectors in HPLC monolithic stationary phases during the past 18 years.

Original languageEnglish
Pages (from-to)2303-2340
Number of pages38
JournalJournal of Separation Science
Issue number14
Early online date3 May 2019
Publication statusPublished - Jul 2019


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