An insight into chiral monolithic stationary phases for enantioselective high-performance liquid chromatography applications

Ali Fouad, Diana Ibrahim, Frady G. Adly, Ashraf Ghanem

Research output: Contribution to journalReview article

Abstract

In this review, three main classes of chiral monolithic stationary phases, namely silica-, organic polymer-, and hybrid-based monolithic stationary phases, are covered. Their preparations, applications, and advantages compared with the conventional-packed and open-tubular capillary columns are discussed. A detailed description of the different types and techniques used for the introduction of chiral selectors into the monolithic matrices such as immobilization, functionalization, coating, encapsulation, and bonding. Special emphasis is given to the recent developments of chiral selectors in HPLC monolithic stationary phases during the past 18 years.

LanguageEnglish
Pages2303-2340
Number of pages38
JournalJournal of Separation Science
DOIs
Publication statusE-pub ahead of print - 3 May 2019

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Organic polymers
High performance liquid chromatography
Encapsulation
Silicon Dioxide
Silica
Coatings

Cite this

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abstract = "In this review, three main classes of chiral monolithic stationary phases, namely silica-, organic polymer-, and hybrid-based monolithic stationary phases, are covered. Their preparations, applications, and advantages compared with the conventional-packed and open-tubular capillary columns are discussed. A detailed description of the different types and techniques used for the introduction of chiral selectors into the monolithic matrices such as immobilization, functionalization, coating, encapsulation, and bonding. Special emphasis is given to the recent developments of chiral selectors in HPLC monolithic stationary phases during the past 18 years.",
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An insight into chiral monolithic stationary phases for enantioselective high-performance liquid chromatography applications. / Fouad, Ali; Ibrahim, Diana; Adly, Frady G.; Ghanem, Ashraf.

In: Journal of Separation Science, 03.05.2019, p. 2303-2340.

Research output: Contribution to journalReview article

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T1 - An insight into chiral monolithic stationary phases for enantioselective high-performance liquid chromatography applications

AU - Fouad, Ali

AU - Ibrahim, Diana

AU - Adly, Frady G.

AU - Ghanem, Ashraf

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KW - chirality

KW - enantioslective separation

KW - HPLC

KW - monoliths

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