TY - JOUR
T1 - An insight into chiral monolithic stationary phases for enantioselective high-performance liquid chromatography applications
AU - Fouad, Ali
AU - Ibrahim, Diana
AU - Adly, Frady G.
AU - Ghanem, Ashraf
N1 - Funding Information:
The Egyptian Cultural Affairs and the University of Canberra are highly acknowledged for the joint PhD program offered to Mr Ali Fouad.
Publisher Copyright:
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2019/7
Y1 - 2019/7
N2 - In this review, three main classes of chiral monolithic stationary phases, namely silica-, organic polymer-, and hybrid-based monolithic stationary phases, are covered. Their preparations, applications, and advantages compared with the conventional-packed and open-tubular capillary columns are discussed. A detailed description of the different types and techniques used for the introduction of chiral selectors into the monolithic matrices such as immobilization, functionalization, coating, encapsulation, and bonding. Special emphasis is given to the recent developments of chiral selectors in HPLC monolithic stationary phases during the past 18 years.
AB - In this review, three main classes of chiral monolithic stationary phases, namely silica-, organic polymer-, and hybrid-based monolithic stationary phases, are covered. Their preparations, applications, and advantages compared with the conventional-packed and open-tubular capillary columns are discussed. A detailed description of the different types and techniques used for the introduction of chiral selectors into the monolithic matrices such as immobilization, functionalization, coating, encapsulation, and bonding. Special emphasis is given to the recent developments of chiral selectors in HPLC monolithic stationary phases during the past 18 years.
KW - chirality
KW - enantioslective separation
KW - HPLC
KW - monoliths
UR - http://www.scopus.com/inward/record.url?scp=85066882277&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/insight-chiral-monolithic-stationary-phases-enantioselective-hplc-applications
U2 - 10.1002/jssc.201900159
DO - 10.1002/jssc.201900159
M3 - Article
C2 - 31050176
AN - SCOPUS:85066882277
SN - 1615-9306
VL - 42
SP - 2303
EP - 2340
JO - Journal of Separation Science
JF - Journal of Separation Science
IS - 14
ER -