Animal and Human Models of Retinal Diseases

Erica L. Fletcher; Alice Pebay; Matt Rutar; Kiana Kakavand; Anna Y. Wang; Kirstan A. Vessey; Andrew I. Jobling; Ursula Greferath

doi:10.1016/B978-0-12-809324-5.24191-6

Animal and Human Models of Retinal Diseases

Erica L. Fletcher, Alice Pebay, Matt Rutar, Kiana Kakavand, Anna Y. Wang, Kirstan A. Vessey, Andrew I. Jobling, Ursula Greferath

Research output: A Conference proceeding or a Chapter in Book › Chapter › peer-review

Abstract

Complex diseases of the retina are the leading causes of irreversible vision loss in industrialized nations. Often the first step in developing novel treatments for these diseases is the use of animal models to support investigations. There are many genetic and environmental models in rodents, cats, dogs and pigs which show features of age related macular degeneration, glaucoma and diabetic retinopathy. This chapter summarizes the most commonly available models and the features of human disease that they replicate.

Original language	English
Title of host publication	The Senses
Subtitle of host publication	A Comprehensive Reference: Volume 1-7, Second Edition
Editors	Bernd Fritzsch
Place of Publication	United States
Publisher	Academic Press
Chapter	1.36
Pages	590-613
Number of pages	24
Volume	1
Edition	2
ISBN (Electronic)	9780128054093
ISBN (Print)	9780128054086
DOIs	https://doi.org/10.1016/B978-0-12-809324-5.24191-6
Publication status	Published - 1 Jan 2020
Externally published	Yes

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10.1016/B978-0-12-809324-5.24191-6

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keywords = "Retinitis pigmentosa, Photoreceptor, Retinal pigment epithelium, Diabetic retinopathy, Animal model, Age related macular degeneration",

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AU - Fletcher, Erica L.

AU - Pebay, Alice

AU - Rutar, Matt

AU - Kakavand, Kiana

AU - Wang, Anna Y.

AU - Vessey, Kirstan A.

AU - Jobling, Andrew I.

AU - Greferath, Ursula

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AB - Complex diseases of the retina are the leading causes of irreversible vision loss in industrialized nations. Often the first step in developing novel treatments for these diseases is the use of animal models to support investigations. There are many genetic and environmental models in rodents, cats, dogs and pigs which show features of age related macular degeneration, glaucoma and diabetic retinopathy. This chapter summarizes the most commonly available models and the features of human disease that they replicate.

KW - Retinitis pigmentosa

KW - Photoreceptor

KW - Retinal pigment epithelium

KW - Diabetic retinopathy

KW - Animal model

KW - Age related macular degeneration

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BT - The Senses

A2 - Fritzsch, Bernd

PB - Academic Press

CY - United States

ER -

Animal and Human Models of Retinal Diseases

Abstract

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