Anti-Aβ antibody target engagement: a response to Siemers et al

Andrew D Watt; Gabriela A N Crespi; Russell A Down; David B Ascher; Adam Gunn; Keyla A Perez; Catriona A McLean; Victor L Villemagne; Michael W Parker; Kevin J Barnham; Luke A Miles

doi:10.1007/s00401-014-1333-8

Anti-Aβ antibody target engagement: a response to Siemers et al

Andrew D Watt, Gabriela A N Crespi, Russell A Down, David B Ascher, Adam Gunn, Keyla A Perez, Catriona A McLean, Victor L Villemagne, Michael W Parker, Kevin J Barnham, Luke A Miles

Research output: Contribution to journal › Comment/debate › peer-review

3 Citations (Scopus)

Abstract

We have read with interest the commentary by Siemers et al. [28] regarding our paper describing the ability of the three anti-Aβ antibodies, bapineuzumab, crenezumab and solanezumab to engage Aβ in both a synthetic and a biological setting. We appreciate the opportunity to clarify any misunderstandings and here provide a brief response to their concerns.

Original language	English
Pages (from-to)	611-614
Number of pages	4
Journal	Acta Neuropathologica
Volume	128
Issue number	4
DOIs	https://doi.org/10.1007/s00401-014-1333-8
Publication status	Published - Oct 2014
Externally published	Yes

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abstract = "We have read with interest the commentary by Siemers et al. [28] regarding our paper describing the ability of the three anti-Aβ antibodies, bapineuzumab, crenezumab and solanezumab to engage Aβ in both a synthetic and a biological setting. We appreciate the opportunity to clarify any misunderstandings and here provide a brief response to their concerns.",

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AU - Watt, Andrew D

AU - Crespi, Gabriela A N

AU - Down, Russell A

AU - Ascher, David B

AU - Gunn, Adam

AU - Perez, Keyla A

AU - McLean, Catriona A

AU - Villemagne, Victor L

AU - Parker, Michael W

AU - Barnham, Kevin J

AU - Miles, Luke A

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AB - We have read with interest the commentary by Siemers et al. [28] regarding our paper describing the ability of the three anti-Aβ antibodies, bapineuzumab, crenezumab and solanezumab to engage Aβ in both a synthetic and a biological setting. We appreciate the opportunity to clarify any misunderstandings and here provide a brief response to their concerns.

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Anti-Aβ antibody target engagement: a response to Siemers et al

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