Anti-Aβ antibody target engagement: a response to Siemers et al

Andrew D Watt; Gabriela A N Crespi; Russell A Down; David B Ascher; Adam Gunn; Keyla A Perez; Catriona A McLean; Victor L Villemagne; Michael W Parker; Kevin J Barnham; Luke A Miles

doi:10.1007/s00401-014-1333-8

Anti-Aβ antibody target engagement: a response to Siemers et al

Andrew D Watt
, Gabriela A N Crespi
, Russell A Down
, David B Ascher
, Adam Gunn
, Keyla A Perez
, Catriona A McLean
, Victor L Villemagne
, Michael W Parker
, Kevin J Barnham
, Luke A Miles

Research output: Contribution to journal › Comment/debate › peer-review

3 Citations (Scopus)

Abstract

We have read with interest the commentary by Siemers et al. [28] regarding our paper describing the ability of the three anti-Aβ antibodies, bapineuzumab, crenezumab and solanezumab to engage Aβ in both a synthetic and a biological setting. We appreciate the opportunity to clarify any misunderstandings and here provide a brief response to their concerns.

Original language	English
Pages (from-to)	611-614
Number of pages	4
Journal	Acta Neuropathologica
Volume	128
Issue number	4
DOIs	https://doi.org/10.1007/s00401-014-1333-8
Publication status	Published - Oct 2014
Externally published	Yes

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title = "Anti-Aβ antibody target engagement: a response to Siemers et al",

abstract = "We have read with interest the commentary by Siemers et al. [28] regarding our paper describing the ability of the three anti-Aβ antibodies, bapineuzumab, crenezumab and solanezumab to engage Aβ in both a synthetic and a biological setting. We appreciate the opportunity to clarify any misunderstandings and here provide a brief response to their concerns.",

author = "Watt, \{Andrew D\} and Crespi, \{Gabriela A N\} and Down, \{Russell A\} and Ascher, \{David B\} and Adam Gunn and Perez, \{Keyla A\} and McLean, \{Catriona A\} and Villemagne, \{Victor L\} and Parker, \{Michael W\} and Barnham, \{Kevin J\} and Miles, \{Luke A\}",

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AU - Watt, Andrew D

AU - Crespi, Gabriela A N

AU - Down, Russell A

AU - Ascher, David B

AU - Gunn, Adam

AU - Perez, Keyla A

AU - McLean, Catriona A

AU - Villemagne, Victor L

AU - Parker, Michael W

AU - Barnham, Kevin J

AU - Miles, Luke A

PY - 2014/10

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AB - We have read with interest the commentary by Siemers et al. [28] regarding our paper describing the ability of the three anti-Aβ antibodies, bapineuzumab, crenezumab and solanezumab to engage Aβ in both a synthetic and a biological setting. We appreciate the opportunity to clarify any misunderstandings and here provide a brief response to their concerns.

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DO - 10.1007/s00401-014-1333-8

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JO - Acta Neuropathologica

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Anti-Aβ antibody target engagement: a response to Siemers et al

Abstract

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