Antibacterial 5α-Spirostane Saponins from the Fruit of Cordyline manners-suttoniae

Trong D. Tran, Malin A. Olsson, Md Abu Choudhury, David J. McMillan, Jason K. Cullen, Peter G. Parsons, Paul V. Bernhardt, Paul W. Reddell, Steven M. Ogbourne

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Antibacterial-activity-guided fractionation of a dichloromethane extract from the fruit of Cordyline manners-suttoniae and subsequent structure-activity investigations resulted in the identification of 10 new (1-10) and one known (11) 5α-spirostane saponin. The structures of the new compounds were established by 1D and 2D NMR analyses. The absolute configurations of the isolated compounds were determined by X-ray diffraction analysis or chemical derivatizations. The most active compound, suttonigenin F (6), inhibited the Gram-positive bacteria Staphylococcus aureus with MIC75 values that were comparable to those of the antibiotic chloramphenicol. Structure-activity relationships were also obtained from the assessment of antibacterial and cytotoxic activities of the isolated saponins.

Original languageEnglish
Pages (from-to)2809-2817
Number of pages9
JournalJournal of Natural Products
Volume82
Issue number10
DOIs
Publication statusPublished - 25 Oct 2019
Externally publishedYes

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