TY - JOUR
T1 - Antioxidant and anti-proliferative properties of Davidson's plum (Davidsonia pruriens F. Muell) phenolic-enriched extracts as affected by different extraction solvents
AU - Chuen, Tiffany L.K.
AU - Vuong, Quan V.
AU - Hirun, Sathira
AU - Bowyer, Michael C.
AU - Predebon, Melanie J.
AU - Goldsmith, Chloe D.
AU - Sakoff, Jennette A.
AU - Scarlett, Christopher J.
N1 - Funding Information:
We acknowledge the following funding support: Ramaciotti Foundation ( ES2012/0104 ), and the University of Newcastle . The authors thank Rainforest Bounty (Queensland, Australia) for donating samples for the current study.
Publisher Copyright:
© 2016 Elsevier GmbH
PY - 2016/12
Y1 - 2016/12
N2 - The Davidson's plum (DP; Davidsonia pruriens F. Muell) is a fruit native to Australia that is a rich source of phenolic compounds. This study investigated the effects of various extraction solvents (ethanol, methanol, acetone and water) on total phenolic content (TPC), antioxidant capacity (ABTS, DPPH, CUPRAC, FRAP assays) and anti-proliferative activity (MTT, CCK-8 assays) of DP. Our data revealed that extraction solvents significantly affected the physico-chemical, antioxidant and anti-proliferative properties of DP extracts. Within the tested solvents, ethanol was found to be the optimal solvent for extraction of bioactive compounds from DP as its extract had the greatest TPC (94.13 GAE/g), flavonoids (78.33 mg RUE/g), proanthocyanidins (5.33 mg CAE/g), anthocyanidins (2.81 mg CGE/g), as well as possessed the highest antioxidant capacity and anti-proliferative activity against a panel of cancer cell lines. This included cancers of the pancreas, breast, lung, brain, skin, colon and ovary. Therefore, further investigations should be conducted to identify key bioactive compounds to determine the potential for utilization in the nutraceutical and phytopharmaceutical industries.
AB - The Davidson's plum (DP; Davidsonia pruriens F. Muell) is a fruit native to Australia that is a rich source of phenolic compounds. This study investigated the effects of various extraction solvents (ethanol, methanol, acetone and water) on total phenolic content (TPC), antioxidant capacity (ABTS, DPPH, CUPRAC, FRAP assays) and anti-proliferative activity (MTT, CCK-8 assays) of DP. Our data revealed that extraction solvents significantly affected the physico-chemical, antioxidant and anti-proliferative properties of DP extracts. Within the tested solvents, ethanol was found to be the optimal solvent for extraction of bioactive compounds from DP as its extract had the greatest TPC (94.13 GAE/g), flavonoids (78.33 mg RUE/g), proanthocyanidins (5.33 mg CAE/g), anthocyanidins (2.81 mg CGE/g), as well as possessed the highest antioxidant capacity and anti-proliferative activity against a panel of cancer cell lines. This included cancers of the pancreas, breast, lung, brain, skin, colon and ovary. Therefore, further investigations should be conducted to identify key bioactive compounds to determine the potential for utilization in the nutraceutical and phytopharmaceutical industries.
KW - Anti-proliferative
KW - Antioxidant
KW - Davidson's plum
KW - Polyphenols
UR - http://www.scopus.com/inward/record.url?scp=84998537538&partnerID=8YFLogxK
U2 - 10.1016/j.hermed.2016.08.005
DO - 10.1016/j.hermed.2016.08.005
M3 - Article
AN - SCOPUS:84998537538
SN - 2210-8033
VL - 6
SP - 187
EP - 192
JO - Journal of Herbal Medicine
JF - Journal of Herbal Medicine
IS - 4
ER -
