Antioxidant and anti-proliferative properties of Davidson's plum (Davidsonia pruriens F. Muell) phenolic-enriched extracts as affected by different extraction solvents

Tiffany L.K. Chuen; Quan V. Vuong; Sathira Hirun; Michael C. Bowyer; Melanie J. Predebon; Chloe D. Goldsmith; Jennette A. Sakoff; Christopher J. Scarlett

doi:10.1016/j.hermed.2016.08.005

Antioxidant and anti-proliferative properties of Davidson's plum (Davidsonia pruriens F. Muell) phenolic-enriched extracts as affected by different extraction solvents

Tiffany L.K. Chuen
, Quan V. Vuong
, Sathira Hirun
, Michael C. Bowyer
, Melanie J. Predebon
, Chloe D. Goldsmith
, Jennette A. Sakoff
, Christopher J. Scarlett

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

The Davidson's plum (DP; Davidsonia pruriens F. Muell) is a fruit native to Australia that is a rich source of phenolic compounds. This study investigated the effects of various extraction solvents (ethanol, methanol, acetone and water) on total phenolic content (TPC), antioxidant capacity (ABTS, DPPH, CUPRAC, FRAP assays) and anti-proliferative activity (MTT, CCK-8 assays) of DP. Our data revealed that extraction solvents significantly affected the physico-chemical, antioxidant and anti-proliferative properties of DP extracts. Within the tested solvents, ethanol was found to be the optimal solvent for extraction of bioactive compounds from DP as its extract had the greatest TPC (94.13 GAE/g), flavonoids (78.33 mg RUE/g), proanthocyanidins (5.33 mg CAE/g), anthocyanidins (2.81 mg CGE/g), as well as possessed the highest antioxidant capacity and anti-proliferative activity against a panel of cancer cell lines. This included cancers of the pancreas, breast, lung, brain, skin, colon and ovary. Therefore, further investigations should be conducted to identify key bioactive compounds to determine the potential for utilization in the nutraceutical and phytopharmaceutical industries.

Original language	English
Pages (from-to)	187-192
Number of pages	6
Journal	Journal of Herbal Medicine
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/j.hermed.2016.08.005
Publication status	Published - Dec 2016
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.hermed.2016.08.005

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Chuen, T. L. K., Vuong, Q. V., Hirun, S., Bowyer, M. C., Predebon, M. J., Goldsmith, C. D., Sakoff, J. A., & Scarlett, C. J. (2016). Antioxidant and anti-proliferative properties of Davidson's plum (Davidsonia pruriens F. Muell) phenolic-enriched extracts as affected by different extraction solvents. Journal of Herbal Medicine, 6(4), 187-192. https://doi.org/10.1016/j.hermed.2016.08.005

@article{b4d2f7ee68e640ba8e45aa0ad5e18dd7,

title = "Antioxidant and anti-proliferative properties of Davidson's plum (Davidsonia pruriens F. Muell) phenolic-enriched extracts as affected by different extraction solvents",

abstract = "The Davidson's plum (DP; Davidsonia pruriens F. Muell) is a fruit native to Australia that is a rich source of phenolic compounds. This study investigated the effects of various extraction solvents (ethanol, methanol, acetone and water) on total phenolic content (TPC), antioxidant capacity (ABTS, DPPH, CUPRAC, FRAP assays) and anti-proliferative activity (MTT, CCK-8 assays) of DP. Our data revealed that extraction solvents significantly affected the physico-chemical, antioxidant and anti-proliferative properties of DP extracts. Within the tested solvents, ethanol was found to be the optimal solvent for extraction of bioactive compounds from DP as its extract had the greatest TPC (94.13 GAE/g), flavonoids (78.33 mg RUE/g), proanthocyanidins (5.33 mg CAE/g), anthocyanidins (2.81 mg CGE/g), as well as possessed the highest antioxidant capacity and anti-proliferative activity against a panel of cancer cell lines. This included cancers of the pancreas, breast, lung, brain, skin, colon and ovary. Therefore, further investigations should be conducted to identify key bioactive compounds to determine the potential for utilization in the nutraceutical and phytopharmaceutical industries.",

keywords = "Anti-proliferative, Antioxidant, Davidson's plum, Polyphenols",

author = "Chuen, \{Tiffany L.K.\} and Vuong, \{Quan V.\} and Sathira Hirun and Bowyer, \{Michael C.\} and Predebon, \{Melanie J.\} and Goldsmith, \{Chloe D.\} and Sakoff, \{Jennette A.\} and Scarlett, \{Christopher J.\}",

note = "Funding Information: We acknowledge the following funding support: Ramaciotti Foundation ( ES2012/0104 ), and the University of Newcastle . The authors thank Rainforest Bounty (Queensland, Australia) for donating samples for the current study. Publisher Copyright: {\textcopyright} 2016 Elsevier GmbH",

year = "2016",

month = dec,

doi = "10.1016/j.hermed.2016.08.005",

language = "English",

volume = "6",

pages = "187--192",

journal = "Journal of Herbal Medicine",

issn = "2210-8033",

publisher = "Urban und Fischer Verlag Jena",

number = "4",

}

Chuen, TLK, Vuong, QV, Hirun, S, Bowyer, MC, Predebon, MJ, Goldsmith, CD, Sakoff, JA & Scarlett, CJ 2016, 'Antioxidant and anti-proliferative properties of Davidson's plum (Davidsonia pruriens F. Muell) phenolic-enriched extracts as affected by different extraction solvents', Journal of Herbal Medicine, vol. 6, no. 4, pp. 187-192. https://doi.org/10.1016/j.hermed.2016.08.005

TY - JOUR

T1 - Antioxidant and anti-proliferative properties of Davidson's plum (Davidsonia pruriens F. Muell) phenolic-enriched extracts as affected by different extraction solvents

AU - Chuen, Tiffany L.K.

AU - Vuong, Quan V.

AU - Hirun, Sathira

AU - Bowyer, Michael C.

AU - Predebon, Melanie J.

AU - Goldsmith, Chloe D.

AU - Sakoff, Jennette A.

AU - Scarlett, Christopher J.

N1 - Funding Information: We acknowledge the following funding support: Ramaciotti Foundation ( ES2012/0104 ), and the University of Newcastle . The authors thank Rainforest Bounty (Queensland, Australia) for donating samples for the current study. Publisher Copyright: © 2016 Elsevier GmbH

PY - 2016/12

Y1 - 2016/12

N2 - The Davidson's plum (DP; Davidsonia pruriens F. Muell) is a fruit native to Australia that is a rich source of phenolic compounds. This study investigated the effects of various extraction solvents (ethanol, methanol, acetone and water) on total phenolic content (TPC), antioxidant capacity (ABTS, DPPH, CUPRAC, FRAP assays) and anti-proliferative activity (MTT, CCK-8 assays) of DP. Our data revealed that extraction solvents significantly affected the physico-chemical, antioxidant and anti-proliferative properties of DP extracts. Within the tested solvents, ethanol was found to be the optimal solvent for extraction of bioactive compounds from DP as its extract had the greatest TPC (94.13 GAE/g), flavonoids (78.33 mg RUE/g), proanthocyanidins (5.33 mg CAE/g), anthocyanidins (2.81 mg CGE/g), as well as possessed the highest antioxidant capacity and anti-proliferative activity against a panel of cancer cell lines. This included cancers of the pancreas, breast, lung, brain, skin, colon and ovary. Therefore, further investigations should be conducted to identify key bioactive compounds to determine the potential for utilization in the nutraceutical and phytopharmaceutical industries.

AB - The Davidson's plum (DP; Davidsonia pruriens F. Muell) is a fruit native to Australia that is a rich source of phenolic compounds. This study investigated the effects of various extraction solvents (ethanol, methanol, acetone and water) on total phenolic content (TPC), antioxidant capacity (ABTS, DPPH, CUPRAC, FRAP assays) and anti-proliferative activity (MTT, CCK-8 assays) of DP. Our data revealed that extraction solvents significantly affected the physico-chemical, antioxidant and anti-proliferative properties of DP extracts. Within the tested solvents, ethanol was found to be the optimal solvent for extraction of bioactive compounds from DP as its extract had the greatest TPC (94.13 GAE/g), flavonoids (78.33 mg RUE/g), proanthocyanidins (5.33 mg CAE/g), anthocyanidins (2.81 mg CGE/g), as well as possessed the highest antioxidant capacity and anti-proliferative activity against a panel of cancer cell lines. This included cancers of the pancreas, breast, lung, brain, skin, colon and ovary. Therefore, further investigations should be conducted to identify key bioactive compounds to determine the potential for utilization in the nutraceutical and phytopharmaceutical industries.

KW - Anti-proliferative

KW - Antioxidant

KW - Davidson's plum

KW - Polyphenols

UR - https://www.scopus.com/pages/publications/84998537538

U2 - 10.1016/j.hermed.2016.08.005

DO - 10.1016/j.hermed.2016.08.005

M3 - Article

AN - SCOPUS:84998537538

SN - 2210-8033

VL - 6

SP - 187

EP - 192

JO - Journal of Herbal Medicine

JF - Journal of Herbal Medicine

IS - 4

ER -

Antioxidant and anti-proliferative properties of Davidson's plum (Davidsonia pruriens F. Muell) phenolic-enriched extracts as affected by different extraction solvents

Abstract

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