Applications of enzymatic and non-enzymatic methods to access enantiomerically pure compounds using kinetic resolution and racemisation

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    Abstract

    The augmented awareness of the importance of chirality and its strong association with biological activity created an immense need for development of enantiomerically pure compounds at a reduced cost. The global sales of chiral technology products in 2008 were 4.3 billion dollars, which increased to 4.5 billion dollars in 2009 (representing 3.3% growth). The market is expected to expand at a compound annual growth rate (CAGR) of 2.8% to reach 5.1 billion dollars by 2014.1 Various methods have been reported to access enantiomerically pure compounds including synthesis from chiral pool, asymmetric synthesis from prochiral substrates and resolution of racemic mixtures2
    Original languageEnglish
    Pages (from-to)6781-6802
    Number of pages22
    JournalTetrahedron
    Volume68
    Issue number34
    DOIs
    Publication statusPublished - 2012

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    Kinetics
    Chirality
    Growth
    Bioactivity
    Sales
    Association reactions
    Technology
    Costs and Cost Analysis
    Substrates
    Costs

    Cite this

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    abstract = "The augmented awareness of the importance of chirality and its strong association with biological activity created an immense need for development of enantiomerically pure compounds at a reduced cost. The global sales of chiral technology products in 2008 were 4.3 billion dollars, which increased to 4.5 billion dollars in 2009 (representing 3.3{\%} growth). The market is expected to expand at a compound annual growth rate (CAGR) of 2.8{\%} to reach 5.1 billion dollars by 2014.1 Various methods have been reported to access enantiomerically pure compounds including synthesis from chiral pool, asymmetric synthesis from prochiral substrates and resolution of racemic mixtures2",
    keywords = "Lipase, Chirality, Resolution",
    author = "Marwa Ahmed and Tamsin Kelly and Ashraf Ghanem",
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    T1 - Applications of enzymatic and non-enzymatic methods to access enantiomerically pure compounds using kinetic resolution and racemisation

    AU - Ahmed, Marwa

    AU - Kelly, Tamsin

    AU - Ghanem, Ashraf

    PY - 2012

    Y1 - 2012

    N2 - The augmented awareness of the importance of chirality and its strong association with biological activity created an immense need for development of enantiomerically pure compounds at a reduced cost. The global sales of chiral technology products in 2008 were 4.3 billion dollars, which increased to 4.5 billion dollars in 2009 (representing 3.3% growth). The market is expected to expand at a compound annual growth rate (CAGR) of 2.8% to reach 5.1 billion dollars by 2014.1 Various methods have been reported to access enantiomerically pure compounds including synthesis from chiral pool, asymmetric synthesis from prochiral substrates and resolution of racemic mixtures2

    AB - The augmented awareness of the importance of chirality and its strong association with biological activity created an immense need for development of enantiomerically pure compounds at a reduced cost. The global sales of chiral technology products in 2008 were 4.3 billion dollars, which increased to 4.5 billion dollars in 2009 (representing 3.3% growth). The market is expected to expand at a compound annual growth rate (CAGR) of 2.8% to reach 5.1 billion dollars by 2014.1 Various methods have been reported to access enantiomerically pure compounds including synthesis from chiral pool, asymmetric synthesis from prochiral substrates and resolution of racemic mixtures2

    KW - Lipase

    KW - Chirality

    KW - Resolution

    U2 - 10.1016/j.tet.2012.05.049

    DO - 10.1016/j.tet.2012.05.049

    M3 - Article

    VL - 68

    SP - 6781

    EP - 6802

    JO - Tetrahedron

    JF - Tetrahedron

    SN - 0040-4020

    IS - 34

    ER -