Association of physical inactivity with increased cardiovascular risk in patients with rheumatoid arthritis

Giorgos S. Metsios, Antonios Stavropoulos-Kalinoglou, Vasileios F. Panoulas, Mat Wilson, Alan M. Nevill, Yiannis Koutedakis, George D. Kitas

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Patients with rheumatoid arthritis (RA) are characterized by reduced physical activity and increased morbidity and mortality from cardiovascular disease (CVD). The aim of this study was to investigate associations between levels of physical activity and CVD risk profile in RA patients. Levels of physical activity were assessed in 65 RA patients (43 females). Using the International Physical Activity Questionnaire, patients were allocated into three groups: active, moderately active and inactive. Anthropometric characteristics, RA activity/severity, multiple classical and novel CVD risk factors and 10-year CVD event probability were assessed and compared among the three groups. Significant differences were detected among groups in systolic blood pressure (P = 0.006), cholesterol (P < 0.001), low-density lipoprotein (P = 0.01), homeostasis model assessment (P = 0.001), type-1 plasminogen activator inhibitor antigen (P < 0.001), tissue-type plasminogen activator antigen (P = 0.019), homocysteine (P = 0.027), fibrinogen (P = 0.001), apolipoprotein B (P = 0.002) and von Willebrand Factor (P = 0.001), with a consistent deterioration from the physically active to the physically inactive group. Multivariate analysis of variance revealed that levels of physical activity were significantly associated with the differences in all of the above variables (P < 0.05) after adjustment for age, weight, sex, smoking status, as well as RA disease activity and severity. This cross-sectional study suggests that physically inactive RA patients have significantly worse CVD risk profile compared with physically active patients. The possible beneficial impact of increased physical activity, including structured exercise, to the CVD risk of RA patients needs to be accurately assessed in prospective studies.

Original languageEnglish
Pages (from-to)188-194
Number of pages7
JournalEuropean Journal of Preventive Cardiology
Volume16
Issue number2
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Rheumatoid Arthritis
Exercise
Cardiovascular Diseases
Blood Pressure
Antigens
Plasminogen Activator Inhibitor 1
von Willebrand Factor
Apolipoproteins B
Homocysteine
Tissue Plasminogen Activator
LDL Lipoproteins
Fibrinogen
Analysis of Variance
Homeostasis
Multivariate Analysis
Cross-Sectional Studies
Smoking
Cholesterol
Prospective Studies
Morbidity

Cite this

Metsios, G. S., Stavropoulos-Kalinoglou, A., Panoulas, V. F., Wilson, M., Nevill, A. M., Koutedakis, Y., & Kitas, G. D. (2009). Association of physical inactivity with increased cardiovascular risk in patients with rheumatoid arthritis. European Journal of Preventive Cardiology, 16(2), 188-194. https://doi.org/10.1097/HJR.0b013e3283271ceb
Metsios, Giorgos S. ; Stavropoulos-Kalinoglou, Antonios ; Panoulas, Vasileios F. ; Wilson, Mat ; Nevill, Alan M. ; Koutedakis, Yiannis ; Kitas, George D. / Association of physical inactivity with increased cardiovascular risk in patients with rheumatoid arthritis. In: European Journal of Preventive Cardiology. 2009 ; Vol. 16, No. 2. pp. 188-194.
@article{3387a81baf8e4590bee2b13b255494e4,
title = "Association of physical inactivity with increased cardiovascular risk in patients with rheumatoid arthritis",
abstract = "Patients with rheumatoid arthritis (RA) are characterized by reduced physical activity and increased morbidity and mortality from cardiovascular disease (CVD). The aim of this study was to investigate associations between levels of physical activity and CVD risk profile in RA patients. Levels of physical activity were assessed in 65 RA patients (43 females). Using the International Physical Activity Questionnaire, patients were allocated into three groups: active, moderately active and inactive. Anthropometric characteristics, RA activity/severity, multiple classical and novel CVD risk factors and 10-year CVD event probability were assessed and compared among the three groups. Significant differences were detected among groups in systolic blood pressure (P = 0.006), cholesterol (P < 0.001), low-density lipoprotein (P = 0.01), homeostasis model assessment (P = 0.001), type-1 plasminogen activator inhibitor antigen (P < 0.001), tissue-type plasminogen activator antigen (P = 0.019), homocysteine (P = 0.027), fibrinogen (P = 0.001), apolipoprotein B (P = 0.002) and von Willebrand Factor (P = 0.001), with a consistent deterioration from the physically active to the physically inactive group. Multivariate analysis of variance revealed that levels of physical activity were significantly associated with the differences in all of the above variables (P < 0.05) after adjustment for age, weight, sex, smoking status, as well as RA disease activity and severity. This cross-sectional study suggests that physically inactive RA patients have significantly worse CVD risk profile compared with physically active patients. The possible beneficial impact of increased physical activity, including structured exercise, to the CVD risk of RA patients needs to be accurately assessed in prospective studies.",
keywords = "cardiovascular disease, cardiovascular risk, exercise, physical activity, rheumatoid arthritis, risk factors",
author = "Metsios, {Giorgos S.} and Antonios Stavropoulos-Kalinoglou and Panoulas, {Vasileios F.} and Mat Wilson and Nevill, {Alan M.} and Yiannis Koutedakis and Kitas, {George D.}",
year = "2009",
doi = "10.1097/HJR.0b013e3283271ceb",
language = "English",
volume = "16",
pages = "188--194",
journal = "European Journal of Preventive Cardiology",
issn = "2047-4873",
publisher = "SAGE Publications Ltd",
number = "2",

}

Metsios, GS, Stavropoulos-Kalinoglou, A, Panoulas, VF, Wilson, M, Nevill, AM, Koutedakis, Y & Kitas, GD 2009, 'Association of physical inactivity with increased cardiovascular risk in patients with rheumatoid arthritis', European Journal of Preventive Cardiology, vol. 16, no. 2, pp. 188-194. https://doi.org/10.1097/HJR.0b013e3283271ceb

Association of physical inactivity with increased cardiovascular risk in patients with rheumatoid arthritis. / Metsios, Giorgos S.; Stavropoulos-Kalinoglou, Antonios; Panoulas, Vasileios F.; Wilson, Mat; Nevill, Alan M.; Koutedakis, Yiannis; Kitas, George D.

In: European Journal of Preventive Cardiology, Vol. 16, No. 2, 2009, p. 188-194.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of physical inactivity with increased cardiovascular risk in patients with rheumatoid arthritis

AU - Metsios, Giorgos S.

AU - Stavropoulos-Kalinoglou, Antonios

AU - Panoulas, Vasileios F.

AU - Wilson, Mat

AU - Nevill, Alan M.

AU - Koutedakis, Yiannis

AU - Kitas, George D.

PY - 2009

Y1 - 2009

N2 - Patients with rheumatoid arthritis (RA) are characterized by reduced physical activity and increased morbidity and mortality from cardiovascular disease (CVD). The aim of this study was to investigate associations between levels of physical activity and CVD risk profile in RA patients. Levels of physical activity were assessed in 65 RA patients (43 females). Using the International Physical Activity Questionnaire, patients were allocated into three groups: active, moderately active and inactive. Anthropometric characteristics, RA activity/severity, multiple classical and novel CVD risk factors and 10-year CVD event probability were assessed and compared among the three groups. Significant differences were detected among groups in systolic blood pressure (P = 0.006), cholesterol (P < 0.001), low-density lipoprotein (P = 0.01), homeostasis model assessment (P = 0.001), type-1 plasminogen activator inhibitor antigen (P < 0.001), tissue-type plasminogen activator antigen (P = 0.019), homocysteine (P = 0.027), fibrinogen (P = 0.001), apolipoprotein B (P = 0.002) and von Willebrand Factor (P = 0.001), with a consistent deterioration from the physically active to the physically inactive group. Multivariate analysis of variance revealed that levels of physical activity were significantly associated with the differences in all of the above variables (P < 0.05) after adjustment for age, weight, sex, smoking status, as well as RA disease activity and severity. This cross-sectional study suggests that physically inactive RA patients have significantly worse CVD risk profile compared with physically active patients. The possible beneficial impact of increased physical activity, including structured exercise, to the CVD risk of RA patients needs to be accurately assessed in prospective studies.

AB - Patients with rheumatoid arthritis (RA) are characterized by reduced physical activity and increased morbidity and mortality from cardiovascular disease (CVD). The aim of this study was to investigate associations between levels of physical activity and CVD risk profile in RA patients. Levels of physical activity were assessed in 65 RA patients (43 females). Using the International Physical Activity Questionnaire, patients were allocated into three groups: active, moderately active and inactive. Anthropometric characteristics, RA activity/severity, multiple classical and novel CVD risk factors and 10-year CVD event probability were assessed and compared among the three groups. Significant differences were detected among groups in systolic blood pressure (P = 0.006), cholesterol (P < 0.001), low-density lipoprotein (P = 0.01), homeostasis model assessment (P = 0.001), type-1 plasminogen activator inhibitor antigen (P < 0.001), tissue-type plasminogen activator antigen (P = 0.019), homocysteine (P = 0.027), fibrinogen (P = 0.001), apolipoprotein B (P = 0.002) and von Willebrand Factor (P = 0.001), with a consistent deterioration from the physically active to the physically inactive group. Multivariate analysis of variance revealed that levels of physical activity were significantly associated with the differences in all of the above variables (P < 0.05) after adjustment for age, weight, sex, smoking status, as well as RA disease activity and severity. This cross-sectional study suggests that physically inactive RA patients have significantly worse CVD risk profile compared with physically active patients. The possible beneficial impact of increased physical activity, including structured exercise, to the CVD risk of RA patients needs to be accurately assessed in prospective studies.

KW - cardiovascular disease

KW - cardiovascular risk

KW - exercise

KW - physical activity

KW - rheumatoid arthritis

KW - risk factors

UR - http://www.scopus.com/inward/record.url?scp=67449096042&partnerID=8YFLogxK

U2 - 10.1097/HJR.0b013e3283271ceb

DO - 10.1097/HJR.0b013e3283271ceb

M3 - Article

VL - 16

SP - 188

EP - 194

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

SN - 2047-4873

IS - 2

ER -