'Aussie normals'

An a priori study to develop clinical chemistry reference intervals in a healthy Australian population

Gus KOERBIN, John A. Cavanaugh, Julia Potter, W Abhayaratna, Nicholas West, Nicholas Glasgow, Chloe Hawkins, D Armbruster, Carmen Oakman, Peter Hickman

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Development of reference intervalsisdifficult, time consuming, expensive and beyond the scope of most laboratories. The Aussie Normals study is a direct a priori study to determine reference intervals in healthy Australian adults. All volunteers completed a health and lifestyle questionnaire and exclusion was basedon conditions such as pregnancy, diabetes, renal or cardiovascular disease. Up to 91 biochemical analyses were undertaken on a variety of analytical platforms using serum samples collected from 1856 volunteers. We report on our findings for 40 of these analytesand two calculated parameters performed on the Abbott ARCHITECTci8200/ci16200 analysers. Not all samples were analysed for all assays due to volume requirements or assay/instrument availability. Results with elevated interference indices and those deemed unsuitable after clinical evaluation were removed from the database. Reference intervals were partitioned based on the method of Harris and Boyd into three scenarios, combined gender, males and females and age and gender. We have performed a detailed reference interval study on a healthy Australian popu-lationconsideringtheeffectsofsex, ageandbodymass. These reference intervals may be adapted to other manufacturer's analytical methods using method transference.
Original languageEnglish
Pages (from-to)138-144
Number of pages7
JournalPathology
Volume47
Issue number2
DOIs
Publication statusPublished - Feb 2015

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Clinical Chemistry
Volunteers
Population
Life Style
Cardiovascular Diseases
Databases
Kidney
Pregnancy
Health
Serum

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KOERBIN, G., Cavanaugh, J. A., Potter, J., Abhayaratna, W., West, N., Glasgow, N., ... Hickman, P. (2015). 'Aussie normals': An a priori study to develop clinical chemistry reference intervals in a healthy Australian population. Pathology, 47(2), 138-144. https://doi.org/10.1097/PAT.0000000000000227
KOERBIN, Gus ; Cavanaugh, John A. ; Potter, Julia ; Abhayaratna, W ; West, Nicholas ; Glasgow, Nicholas ; Hawkins, Chloe ; Armbruster, D ; Oakman, Carmen ; Hickman, Peter. / 'Aussie normals' : An a priori study to develop clinical chemistry reference intervals in a healthy Australian population. In: Pathology. 2015 ; Vol. 47, No. 2. pp. 138-144.
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KOERBIN, G, Cavanaugh, JA, Potter, J, Abhayaratna, W, West, N, Glasgow, N, Hawkins, C, Armbruster, D, Oakman, C & Hickman, P 2015, ''Aussie normals': An a priori study to develop clinical chemistry reference intervals in a healthy Australian population', Pathology, vol. 47, no. 2, pp. 138-144. https://doi.org/10.1097/PAT.0000000000000227

'Aussie normals' : An a priori study to develop clinical chemistry reference intervals in a healthy Australian population. / KOERBIN, Gus; Cavanaugh, John A.; Potter, Julia; Abhayaratna, W; West, Nicholas; Glasgow, Nicholas; Hawkins, Chloe; Armbruster, D; Oakman, Carmen; Hickman, Peter.

In: Pathology, Vol. 47, No. 2, 02.2015, p. 138-144.

Research output: Contribution to journalArticle

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