BAFF augments certain Th1-associated inflammatory responses

Andrew P. R Sutherland, Lai Guan Ng, Carrie A. Fletcher, Bennett Shum, Rebecca A. Newton, Shane T. Grey, Michael Rolph, Fabienne Mackay, Charles Mackay

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Abstract

B cell-activating factor belonging to the TNF family (BAFF; BLyS) is a critical regulator of B cell maturation and survival, and its overexpression in BAFF transgenic (Tg) mice results in the development of autoimmune disorders. BAFF also affects T cell function through binding to one of the BAFF receptors, BAFF-R. Using BAFF Tg mice, we examined a typical Th1-mediated response, the cutaneous delayed-type hypersensitivity reaction, and found a much greater degree of paw swelling and inflammation than in control mice. Importantly, delayed-type hypersensitivity scores correlated directly with BAFF levels in serum. Conversely, in a Th2-mediated model of allergic airway inflammation, BAFF Tg mice were largely protected and showed markedly reduced Ag-specific T cell proliferation and eosinophil infiltration associated with the airways. Thus, local and/or systemically distributed BAFF affects Th1 and Th2 responses and impacts on the course of some T cell-mediated inflammatory reactions. Our results are consistent with the idea that BAFF augments T cell as well as B cell responses, particularly Th1-type responses. Results in BAFF Tg mice may reflect the situation in certain autoimmune patients or virally infected individuals, because BAFF levels in blood are comparable
Original languageEnglish
Pages (from-to)5537-5544
Number of pages8
JournalJournal of Immunology
Volume174
DOIs
Publication statusPublished - 2005
Externally publishedYes

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Sutherland, A. P. R., Ng, L. G., Fletcher, C. A., Shum, B., Newton, R. A., Grey, S. T., ... Mackay, C. (2005). BAFF augments certain Th1-associated inflammatory responses. Journal of Immunology, 174, 5537-5544. https://doi.org/10.4049/jimmunol.174.9.5537