BAFF augments certain Th1-associated inflammatory responses

Andrew P. R Sutherland, Lai Guan Ng, Carrie A. Fletcher, Bennett Shum, Rebecca A. Newton, Shane T. Grey, Michael Rolph, Fabienne Mackay, Charles Mackay

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B cell-activating factor belonging to the TNF family (BAFF; BLyS) is a critical regulator of B cell maturation and survival, and its overexpression in BAFF transgenic (Tg) mice results in the development of autoimmune disorders. BAFF also affects T cell function through binding to one of the BAFF receptors, BAFF-R. Using BAFF Tg mice, we examined a typical Th1-mediated response, the cutaneous delayed-type hypersensitivity reaction, and found a much greater degree of paw swelling and inflammation than in control mice. Importantly, delayed-type hypersensitivity scores correlated directly with BAFF levels in serum. Conversely, in a Th2-mediated model of allergic airway inflammation, BAFF Tg mice were largely protected and showed markedly reduced Ag-specific T cell proliferation and eosinophil infiltration associated with the airways. Thus, local and/or systemically distributed BAFF affects Th1 and Th2 responses and impacts on the course of some T cell-mediated inflammatory reactions. Our results are consistent with the idea that BAFF augments T cell as well as B cell responses, particularly Th1-type responses. Results in BAFF Tg mice may reflect the situation in certain autoimmune patients or virally infected individuals, because BAFF levels in blood are comparable
Original languageEnglish
Pages (from-to)5537-5544
Number of pages8
JournalJournal of Immunology
Publication statusPublished - 2005
Externally publishedYes


Cite this

Sutherland, A. P. R., Ng, L. G., Fletcher, C. A., Shum, B., Newton, R. A., Grey, S. T., ... Mackay, C. (2005). BAFF augments certain Th1-associated inflammatory responses. Journal of Immunology, 174, 5537-5544.