Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 189-197 |
| Number of pages | 9 |
| Journal | Food Chemistry |
| Volume | 212 |
| DOIs | |
| Publication status | Published - 2016 |
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Bioaccessibility and degradation of naturally occurring arsenic species from food in the human gastrointestinal tract. / GONZALEZ DE CHAVEZ CAPILLA, Teresa; Beshai, Mona; MAHER, Bill; KELLY, Tamsin; FOSTER, Simon.
In: Food Chemistry, Vol. 212, 2016, p. 189-197.Research output: Contribution to journal › Article
TY - JOUR
T1 - Bioaccessibility and degradation of naturally occurring arsenic species from food in the human gastrointestinal tract
AU - GONZALEZ DE CHAVEZ CAPILLA, Teresa
AU - Beshai, Mona
AU - MAHER, Bill
AU - KELLY, Tamsin
AU - FOSTER, Simon
PY - 2016
Y1 - 2016
N2 - Humans are exposed to organic arsenic species through their diet and therefore, are susceptible to arsenic toxicity. Investigating the transformations occurring in the gastrointestinal tract will influence which arsenic species to focus on when studying metabolism in cells. Using a physiologically based extraction test, the bioaccessibility of arsenic species was determined after the simulated gastrointestinal digestion of rice, seaweed and fish. Pure standards of the major arsenic species present in these foodstuffs (arsenic glutathione complexes, arsenosugars and short chain fatty acids) were also evaluated to assess the effect of the food matrix on bioaccessibility and transformation. Approximately 80% of arsenic is released from these foodstuffs, potentially becoming available. Hydrolysis and demethylation of arsenic glutathione complexes and arsenosugars standards was observed, but no transformations occurred to arsenosugars present in seaweed. Demethylation of MA and DMA from rice occurs increasing the amount of inorganic arsenic species available for metabolism.
AB - Humans are exposed to organic arsenic species through their diet and therefore, are susceptible to arsenic toxicity. Investigating the transformations occurring in the gastrointestinal tract will influence which arsenic species to focus on when studying metabolism in cells. Using a physiologically based extraction test, the bioaccessibility of arsenic species was determined after the simulated gastrointestinal digestion of rice, seaweed and fish. Pure standards of the major arsenic species present in these foodstuffs (arsenic glutathione complexes, arsenosugars and short chain fatty acids) were also evaluated to assess the effect of the food matrix on bioaccessibility and transformation. Approximately 80% of arsenic is released from these foodstuffs, potentially becoming available. Hydrolysis and demethylation of arsenic glutathione complexes and arsenosugars standards was observed, but no transformations occurred to arsenosugars present in seaweed. Demethylation of MA and DMA from rice occurs increasing the amount of inorganic arsenic species available for metabolism.
KW - Arsenic glutathione complexes
KW - Arsenolipids
KW - Arsenosugars
KW - Fish
KW - Gastrointestinal digestion
KW - Rice
KW - Seaweed
UR - http://www.scopus.com/inward/record.url?scp=84974602538&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/bioaccessibility-degradation-naturally-occurring-arsenic-species-food-human-gastrointestinal-tract
U2 - 10.1016/j.foodchem.2016.05.163
DO - 10.1016/j.foodchem.2016.05.163
M3 - Article
VL - 212
SP - 189
EP - 197
JO - Journal of Micronutrient Analysis
JF - Journal of Micronutrient Analysis
SN - 0308-8146
ER -