Bioaccessibility and degradation of naturally occurring arsenic species from food in the human gastrointestinal tract

Teresa GONZALEZ DE CHAVEZ CAPILLA, Mona Beshai, Bill MAHER, Tamsin KELLY, Simon FOSTER

    Research output: Contribution to journal › Article

    19 Citations (Scopus)

    Abstract

    Humans are exposed to organic arsenic species through their diet and therefore, are susceptible to arsenic toxicity. Investigating the transformations occurring in the gastrointestinal tract will influence which arsenic species to focus on when studying metabolism in cells. Using a physiologically based extraction test, the bioaccessibility of arsenic species was determined after the simulated gastrointestinal digestion of rice, seaweed and fish. Pure standards of the major arsenic species present in these foodstuffs (arsenic glutathione complexes, arsenosugars and short chain fatty acids) were also evaluated to assess the effect of the food matrix on bioaccessibility and transformation. Approximately 80% of arsenic is released from these foodstuffs, potentially becoming available. Hydrolysis and demethylation of arsenic glutathione complexes and arsenosugars standards was observed, but no transformations occurred to arsenosugars present in seaweed. Demethylation of MA and DMA from rice occurs increasing the amount of inorganic arsenic species available for metabolism.
    Original languageEnglish
    Pages (from-to)189-197
    Number of pages9
    JournalFood Chemistry
    Volume212
    DOIs
    Publication statusPublished - 2016

    Fingerprint

    Arsenic
    arsenic
    gastrointestinal system
    Gastrointestinal Tract
    Food
    Degradation
    degradation
    Seaweed
    edible seaweed
    Metabolism
    Glutathione
    glutathione
    rice
    metabolism
    Volatile Fatty Acids
    food matrix
    short chain fatty acids
    Dynamic mechanical analysis
    Nutrition
    Fish

    Cite this

    GONZALEZ DE CHAVEZ CAPILLA, Teresa ; Beshai, Mona ; MAHER, Bill ; KELLY, Tamsin ; FOSTER, Simon. / Bioaccessibility and degradation of naturally occurring arsenic species from food in the human gastrointestinal tract. In: Food Chemistry. 2016 ; Vol. 212. pp. 189-197.
    @article{548c09217613481ab2fc9d19d2c30606,
    title = "Bioaccessibility and degradation of naturally occurring arsenic species from food in the human gastrointestinal tract",
    abstract = "Humans are exposed to organic arsenic species through their diet and therefore, are susceptible to arsenic toxicity. Investigating the transformations occurring in the gastrointestinal tract will influence which arsenic species to focus on when studying metabolism in cells. Using a physiologically based extraction test, the bioaccessibility of arsenic species was determined after the simulated gastrointestinal digestion of rice, seaweed and fish. Pure standards of the major arsenic species present in these foodstuffs (arsenic glutathione complexes, arsenosugars and short chain fatty acids) were also evaluated to assess the effect of the food matrix on bioaccessibility and transformation. Approximately 80{\%} of arsenic is released from these foodstuffs, potentially becoming available. Hydrolysis and demethylation of arsenic glutathione complexes and arsenosugars standards was observed, but no transformations occurred to arsenosugars present in seaweed. Demethylation of MA and DMA from rice occurs increasing the amount of inorganic arsenic species available for metabolism.",
    keywords = "Arsenic glutathione complexes, Arsenolipids, Arsenosugars, Fish, Gastrointestinal digestion, Rice, Seaweed",
    author = "{GONZALEZ DE CHAVEZ CAPILLA}, Teresa and Mona Beshai and Bill MAHER and Tamsin KELLY and Simon FOSTER",
    year = "2016",
    doi = "10.1016/j.foodchem.2016.05.163",
    language = "English",
    volume = "212",
    pages = "189--197",
    journal = "Journal of Micronutrient Analysis",
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    GONZALEZ DE CHAVEZ CAPILLA, T, Beshai, M, MAHER, B, KELLY, T & FOSTER, S 2016, 'Bioaccessibility and degradation of naturally occurring arsenic species from food in the human gastrointestinal tract', Food Chemistry, vol. 212, pp. 189-197. https://doi.org/10.1016/j.foodchem.2016.05.163

    Bioaccessibility and degradation of naturally occurring arsenic species from food in the human gastrointestinal tract. / GONZALEZ DE CHAVEZ CAPILLA, Teresa; Beshai, Mona; MAHER, Bill; KELLY, Tamsin; FOSTER, Simon.

    In: Food Chemistry, Vol. 212, 2016, p. 189-197.

    Research output: Contribution to journal › Article

    TY - JOUR

    T1 - Bioaccessibility and degradation of naturally occurring arsenic species from food in the human gastrointestinal tract

    AU - GONZALEZ DE CHAVEZ CAPILLA, Teresa

    AU - Beshai, Mona

    AU - MAHER, Bill

    AU - KELLY, Tamsin

    AU - FOSTER, Simon

    PY - 2016

    Y1 - 2016

    N2 - Humans are exposed to organic arsenic species through their diet and therefore, are susceptible to arsenic toxicity. Investigating the transformations occurring in the gastrointestinal tract will influence which arsenic species to focus on when studying metabolism in cells. Using a physiologically based extraction test, the bioaccessibility of arsenic species was determined after the simulated gastrointestinal digestion of rice, seaweed and fish. Pure standards of the major arsenic species present in these foodstuffs (arsenic glutathione complexes, arsenosugars and short chain fatty acids) were also evaluated to assess the effect of the food matrix on bioaccessibility and transformation. Approximately 80% of arsenic is released from these foodstuffs, potentially becoming available. Hydrolysis and demethylation of arsenic glutathione complexes and arsenosugars standards was observed, but no transformations occurred to arsenosugars present in seaweed. Demethylation of MA and DMA from rice occurs increasing the amount of inorganic arsenic species available for metabolism.

    AB - Humans are exposed to organic arsenic species through their diet and therefore, are susceptible to arsenic toxicity. Investigating the transformations occurring in the gastrointestinal tract will influence which arsenic species to focus on when studying metabolism in cells. Using a physiologically based extraction test, the bioaccessibility of arsenic species was determined after the simulated gastrointestinal digestion of rice, seaweed and fish. Pure standards of the major arsenic species present in these foodstuffs (arsenic glutathione complexes, arsenosugars and short chain fatty acids) were also evaluated to assess the effect of the food matrix on bioaccessibility and transformation. Approximately 80% of arsenic is released from these foodstuffs, potentially becoming available. Hydrolysis and demethylation of arsenic glutathione complexes and arsenosugars standards was observed, but no transformations occurred to arsenosugars present in seaweed. Demethylation of MA and DMA from rice occurs increasing the amount of inorganic arsenic species available for metabolism.

    KW - Arsenic glutathione complexes

    KW - Arsenolipids

    KW - Arsenosugars

    KW - Fish

    KW - Gastrointestinal digestion

    KW - Rice

    KW - Seaweed

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    DO - 10.1016/j.foodchem.2016.05.163

    M3 - Article

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    GONZALEZ DE CHAVEZ CAPILLA T, Beshai M, MAHER B, KELLY T, FOSTER S. Bioaccessibility and degradation of naturally occurring arsenic species from food in the human gastrointestinal tract. Food Chemistry. 2016;212:189-197. https://doi.org/10.1016/j.foodchem.2016.05.163

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