Borrelia burgdorferi Has Minimal Impact on the Lyme Disease Reservoir Host Peromyscus leucopus

Lisa Schwanz, Maarten Voordouw, D Brisson, R Ostfeld

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


The epidemiology of vector-borne zoonotic diseases is determined by encounter rates between vectors and hosts. Alterations to the behavior of reservoir hosts caused by the infectious agent have the potential to dramatically alter disease transmission and human risk. We examined the effect of Borrelia burgdorferi, the etiological agent of Lyme disease, on one of its most important reservoir hosts, the white-footed mouse, Peromyscus leucopus. We mimic natural infections in mice using the vector (Black-legged ticks, Ixodes scapularis) and examine the immunological and behavioral responses of mouse hosts. Despite producing antibodies against B. burgdorferi, infected mice did not have elevated white blood cells compared with uninfected mice. In addition, nfected and uninfected mice did not differ in their wheel-running activity. Our results suggest that infection with the spirochete B. burgdorferi has little impact on the field activity of white-footed mice. Lyme disease transmission appears to be uncomplicated by pathogen-altered behavior of this reservoir host.
Original languageEnglish
Pages (from-to)117-124
Number of pages8
JournalVector-Borne and Zoonotic Diseases
Publication statusPublished - 2011
Externally publishedYes


Dive into the research topics of 'Borrelia burgdorferi Has Minimal Impact on the Lyme Disease Reservoir Host Peromyscus leucopus'. Together they form a unique fingerprint.

Cite this