Cardiac autonomic function and its association with cardiometabolic disease risk factors in Black South African children

Stuart SEMPLE, Andrew MCKUNE, Anneke Van Biljon, Katrina D. DuBose, Unathi Kolanisi

Research output: Contribution to journalArticle

Abstract

Objective:This study evaluated the associations between cardiac autonomic nervous system (ANS) activity andcardiometabolic disease (CMD) risk factors among black South African children.Design:The participants included 34 black South African children (11.85 ± 0.89 y). CMD risk factors includedwaist circumference (WC), hip circumference (HC), body mass index z-score (BMI z-score), blood pressure (SBP,DBP), total cholesterol (TC), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol(LDL), fasting glucose (FG), fasting insulin (FINS), and vessel stiffness index (SI). Heart rate variability was usedto quantify cardiac ANS activity.Results:lnRMSSD, pNN50 and lnSD1 were inversely associated with FINS (r=−0.33,p= 0.05;r=−0.36,p= 0.03;r=−0.41,p= 0.01), WC (r=−0.45,p= 0.01;r=−0.39,p= 0.02; r =−0.45,p= 0.01), and HC(r =−0.41,p= 0.01; r =−0.36,p= 0.03;r=−0.43,p= 0.01). HDL was positively associated withlnRMSSD (r= 0.37;p= 0.03) and lnSD1 (r = 0.37;p= 0.03) while, LDL was negatively associated with HF(r =−0.41;p= 0.01). Regression analysis identified WC as the primary predictor for parasympathetic mod-ulation in time domain (lnRMSSD: r2 = 0.21,p= 0.01; pNN50: r2 = 0.18,p= 0.01) and non-linear domain(lnSD1: r2 = 0.21,p= 0.01).Conclusion:Elevated resting parasympathetic activity in children is associated with lower CMD risk factors andan elevation in the protective HDL.
LanguageEnglish
Article number219
Pages1-4
Number of pages4
JournalAutonomic Neuroscience
Volume219
DOIs
Publication statusPublished - 1 Jul 2019

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HDL Cholesterol
Fasting
Autonomic Nervous System
LDL Cholesterol
Hip
Insulin
Body Mass Index
Heart Rate
Cholesterol
Regression Analysis
Blood Pressure
Glucose

Cite this

@article{fe47f8eb3e154e1884581176bdc975b5,
title = "Cardiac autonomic function and its association with cardiometabolic disease risk factors in Black South African children",
abstract = "Objective:This study evaluated the associations between cardiac autonomic nervous system (ANS) activity andcardiometabolic disease (CMD) risk factors among black South African children.Design:The participants included 34 black South African children (11.85 ± 0.89 y). CMD risk factors includedwaist circumference (WC), hip circumference (HC), body mass index z-score (BMI z-score), blood pressure (SBP,DBP), total cholesterol (TC), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol(LDL), fasting glucose (FG), fasting insulin (FINS), and vessel stiffness index (SI). Heart rate variability was usedto quantify cardiac ANS activity.Results:lnRMSSD, pNN50 and lnSD1 were inversely associated with FINS (r=−0.33,p= 0.05;r=−0.36,p= 0.03;r=−0.41,p= 0.01), WC (r=−0.45,p= 0.01;r=−0.39,p= 0.02; r =−0.45,p= 0.01), and HC(r =−0.41,p= 0.01; r =−0.36,p= 0.03;r=−0.43,p= 0.01). HDL was positively associated withlnRMSSD (r= 0.37;p= 0.03) and lnSD1 (r = 0.37;p= 0.03) while, LDL was negatively associated with HF(r =−0.41;p= 0.01). Regression analysis identified WC as the primary predictor for parasympathetic mod-ulation in time domain (lnRMSSD: r2 = 0.21,p= 0.01; pNN50: r2 = 0.18,p= 0.01) and non-linear domain(lnSD1: r2 = 0.21,p= 0.01).Conclusion:Elevated resting parasympathetic activity in children is associated with lower CMD risk factors andan elevation in the protective HDL.",
keywords = "Black children, Cardiac autonomic nervous system, Cardiometabolic disease risk factors, Insulin concentrations, Lipid profile, Obesity indicators",
author = "Stuart SEMPLE and Andrew MCKUNE and {Van Biljon}, Anneke and {D. DuBose}, Katrina and Unathi Kolanisi",
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Cardiac autonomic function and its association with cardiometabolic disease risk factors in Black South African children. / SEMPLE, Stuart; MCKUNE, Andrew; Van Biljon, Anneke ; D. DuBose, Katrina ; Kolanisi, Unathi.

In: Autonomic Neuroscience, Vol. 219, 219, 01.07.2019, p. 1-4.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cardiac autonomic function and its association with cardiometabolic disease risk factors in Black South African children

AU - SEMPLE, Stuart

AU - MCKUNE, Andrew

AU - Van Biljon, Anneke

AU - D. DuBose, Katrina

AU - Kolanisi, Unathi

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Objective:This study evaluated the associations between cardiac autonomic nervous system (ANS) activity andcardiometabolic disease (CMD) risk factors among black South African children.Design:The participants included 34 black South African children (11.85 ± 0.89 y). CMD risk factors includedwaist circumference (WC), hip circumference (HC), body mass index z-score (BMI z-score), blood pressure (SBP,DBP), total cholesterol (TC), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol(LDL), fasting glucose (FG), fasting insulin (FINS), and vessel stiffness index (SI). Heart rate variability was usedto quantify cardiac ANS activity.Results:lnRMSSD, pNN50 and lnSD1 were inversely associated with FINS (r=−0.33,p= 0.05;r=−0.36,p= 0.03;r=−0.41,p= 0.01), WC (r=−0.45,p= 0.01;r=−0.39,p= 0.02; r =−0.45,p= 0.01), and HC(r =−0.41,p= 0.01; r =−0.36,p= 0.03;r=−0.43,p= 0.01). HDL was positively associated withlnRMSSD (r= 0.37;p= 0.03) and lnSD1 (r = 0.37;p= 0.03) while, LDL was negatively associated with HF(r =−0.41;p= 0.01). Regression analysis identified WC as the primary predictor for parasympathetic mod-ulation in time domain (lnRMSSD: r2 = 0.21,p= 0.01; pNN50: r2 = 0.18,p= 0.01) and non-linear domain(lnSD1: r2 = 0.21,p= 0.01).Conclusion:Elevated resting parasympathetic activity in children is associated with lower CMD risk factors andan elevation in the protective HDL.

AB - Objective:This study evaluated the associations between cardiac autonomic nervous system (ANS) activity andcardiometabolic disease (CMD) risk factors among black South African children.Design:The participants included 34 black South African children (11.85 ± 0.89 y). CMD risk factors includedwaist circumference (WC), hip circumference (HC), body mass index z-score (BMI z-score), blood pressure (SBP,DBP), total cholesterol (TC), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol(LDL), fasting glucose (FG), fasting insulin (FINS), and vessel stiffness index (SI). Heart rate variability was usedto quantify cardiac ANS activity.Results:lnRMSSD, pNN50 and lnSD1 were inversely associated with FINS (r=−0.33,p= 0.05;r=−0.36,p= 0.03;r=−0.41,p= 0.01), WC (r=−0.45,p= 0.01;r=−0.39,p= 0.02; r =−0.45,p= 0.01), and HC(r =−0.41,p= 0.01; r =−0.36,p= 0.03;r=−0.43,p= 0.01). HDL was positively associated withlnRMSSD (r= 0.37;p= 0.03) and lnSD1 (r = 0.37;p= 0.03) while, LDL was negatively associated with HF(r =−0.41;p= 0.01). Regression analysis identified WC as the primary predictor for parasympathetic mod-ulation in time domain (lnRMSSD: r2 = 0.21,p= 0.01; pNN50: r2 = 0.18,p= 0.01) and non-linear domain(lnSD1: r2 = 0.21,p= 0.01).Conclusion:Elevated resting parasympathetic activity in children is associated with lower CMD risk factors andan elevation in the protective HDL.

KW - Black children

KW - Cardiac autonomic nervous system

KW - Cardiometabolic disease risk factors

KW - Insulin concentrations

KW - Lipid profile

KW - Obesity indicators

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