TY - JOUR
T1 - Cerebral atrophy in mild cognitive impairment
T2 - A systematic review with meta-analysis
AU - Tabatabaei-Jafari, Hossein
AU - Shaw, Marnie E.
AU - Cherbuin, Nicolas
N1 - Funding Information:
This study was funded by Australian Research Council project grant number 120101705 . The funding sources were not involved in the design, collection, analysis or interpretation of data; or in the writing of the report or the decision to submit.
Publisher Copyright:
© 2015 The Authors.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Introduction: Although mild cognitive impairment (MCI) diagnosis is mainly based on cognitive assessment, reliable estimates of structural changes in specific brain regions, that could be contrasted against normal brain aging and inform diagnosis, are lacking. This study aimed to systematically review the literature reporting on MCI-related brain changes. Methods: The MEDLINE database was searched for studies investigating longitudinal structural changes in MCI. Studies with compatible data were included in the meta-analyses. A qualitative review was conducted for studies excluded from meta-analyses. Results: The analyses revealed a 2.2-fold higher volume loss in the hippocampus, 1.8-fold in the whole brain, and 1.5-fold in the entorhinal cortex in MCI participants. Conclusion: Although the medial temporal lobe is likely to be more vulnerable to MCI pathology, atrophy in this brain area represents a relatively small proportion of whole brain loss, suggesting that future investigations are needed to identify the source of unaccounted volume loss in MCI.
AB - Introduction: Although mild cognitive impairment (MCI) diagnosis is mainly based on cognitive assessment, reliable estimates of structural changes in specific brain regions, that could be contrasted against normal brain aging and inform diagnosis, are lacking. This study aimed to systematically review the literature reporting on MCI-related brain changes. Methods: The MEDLINE database was searched for studies investigating longitudinal structural changes in MCI. Studies with compatible data were included in the meta-analyses. A qualitative review was conducted for studies excluded from meta-analyses. Results: The analyses revealed a 2.2-fold higher volume loss in the hippocampus, 1.8-fold in the whole brain, and 1.5-fold in the entorhinal cortex in MCI participants. Conclusion: Although the medial temporal lobe is likely to be more vulnerable to MCI pathology, atrophy in this brain area represents a relatively small proportion of whole brain loss, suggesting that future investigations are needed to identify the source of unaccounted volume loss in MCI.
KW - Brain atrophy
KW - Entorhinal cortex
KW - Hippocampus
KW - Mild cognitive impairment
KW - MRI
UR - http://www.scopus.com/inward/record.url?scp=84954124863&partnerID=8YFLogxK
U2 - 10.1016/j.dadm.2015.11.002
DO - 10.1016/j.dadm.2015.11.002
M3 - Article
AN - SCOPUS:84954124863
SN - 2352-8729
VL - 1
SP - 487
EP - 504
JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
IS - 4
ER -
