TY - JOUR
T1 - Challenges and Opportunities in the Management of Onychomycosis
AU - Christenson, Julia K.
AU - Peterson, Gregory M.
AU - Naunton, Mark
AU - Bushell, Mary
AU - Kosari, Sam
AU - Baby, Kavya E.
AU - Thomas, Jackson
PY - 2018/7/24
Y1 - 2018/7/24
N2 - Onychomycosis is an increasingly common fungal nail infection, chiefly caused by dermatophyte fungi. The disease is notoriously difficult to treat due to the deep-seated nature of fungi within the nail plate, prolonged treatment requirements, poor patient adherence and frequent recurrences. Given the poor efficacy of currently available topical and systemic therapies, there is a renewed interest in exploring alternative treatment modalities for onychomycosis. Natural therapies, physical treatments and various combination therapies have all shown potential for the management of onychomycosis, though research on many of these methods is still in preliminary stages. Further large, well-designed, randomised controlled trials are necessary to confirm the efficacy of these novel treatments in order to make formal recommendations regarding their use in the management of onychomycosis.
AB - Onychomycosis is an increasingly common fungal nail infection, chiefly caused by dermatophyte fungi. The disease is notoriously difficult to treat due to the deep-seated nature of fungi within the nail plate, prolonged treatment requirements, poor patient adherence and frequent recurrences. Given the poor efficacy of currently available topical and systemic therapies, there is a renewed interest in exploring alternative treatment modalities for onychomycosis. Natural therapies, physical treatments and various combination therapies have all shown potential for the management of onychomycosis, though research on many of these methods is still in preliminary stages. Further large, well-designed, randomised controlled trials are necessary to confirm the efficacy of these novel treatments in order to make formal recommendations regarding their use in the management of onychomycosis.
KW - onychomycosis
KW - nail
KW - fungi
KW - infection
KW - treatment
KW - alternative treatment
KW - combination therapy
UR - http://www.scopus.com/inward/record.url?scp=85056747303&partnerID=8YFLogxK
U2 - 10.3390/jof4030087
DO - 10.3390/jof4030087
M3 - Review article
C2 - 30042327
SN - 2309-608X
VL - 4
SP - 1
EP - 10
JO - Journal of fungi (Basel, Switzerland)
JF - Journal of fungi (Basel, Switzerland)
IS - 87
ER -