Changes in Macular function with Multifocal Pupillography and its spatial correlation with severity of Diabetic Retinopathy

Faran SABETI, Corinne F. Carle, Christopher Nolan, Alicia J. Jenkins, Rohan W. Essex, Lauren Baker, Rakesh Iyer, Caitlin Coombes, Veronica Cheung, Melody Chiou, Ted Maddess

Research output: Contribution to conference (non-published works)Paperpeer-review

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Purpose. We compared the relationship between central retinal structure, and central retinal function as assessed multifocal pupillographic objective perimetry (mfPOP), in patients with Type 1 and Type 2 diabetes.
Methods. Pupillary responses were measured in thirty patients without retinopathy and thirty patients with retinopathy (25 with Type 1 diabetes, aged 52.7 ± 15.8 y; 35 with Type 2 diabetes, 61.6 ± 10.9 yr), and 43 age-matched controls (61.2 ± 9.3 y). mfPOP response amplitudes and delays within the central 30° of fixation were compared to the spatially corresponding full retinal thickness regions in the Early Treatment Diabetic Retinopathy Study (ETDRS) zones measured with optical coherence tomography (OCT).
Results. The results showed that there was no significant difference in central retinal thickness, retinal nerve fiber layer (RNFL) thickness, or HbA1c for all subject groups. Patients with Type 1 diabetes (T1D) had significantly reduced response amplitudes compared to controls and T2D group (P < 0.001), and this functional loss increased with progression to retinopathy. Response delays were significantly greater in both T1D and T2D compared to controls. Local correlations between retinal thickness and mfPOP reached significance towards the borders of macula in both patient groups (P < 0.05).
Conclusion. Neuroretinal dysfunction measured by mfPOP amplitude loss and delays in T1D is worse than in T2D. A positive spatial correlation between retinal thickness and mfPOP responses in peripheral ETDRS regions in eyes with retinopathy might indicate that regions outside the central retina are more vulnerable in earlier stages of disease.
Original languageEnglish
Number of pages11
Publication statusPublished - Jul 2018
EventScientific and Educators Meeting in Optometry: SEMO - Melbourne, Melbourne, Australia
Duration: 5 Apr 20186 Apr 2018 (Facebook event)


ConferenceScientific and Educators Meeting in Optometry
Internet address


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