Characterization of gene expression profiles in HBV-related liver fibrosis patients and identification of ITGBL1 as a key regulator of fibrogenesis

Mingjie Wang, Qiming Gong, Jiming Zhang, Liang Chen, Zhanqing Zhang, Lungen Lu, Demin Yu, Yue Han, Donghua Zhang, Peizhan Chen, Xiaonan Zhang, Zhenghong Yuan, Jinyan Huang, Xinxin Zhang

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Although hepatitis B virus (HBV) infection is the leading cause of liver fibrosis (LF), the mechanisms underlying liver fibrotic progression remain unclear. Here, we investigated the gene expression profiles of HBV-related LF patients. Whole genome expression arrays were used to detect gene expression in liver biopsy samples from chronically HBV infected patients. Through integrative data analysis, we identified several pathways and key genes involved in the initiation and exacerbation of liver fibrosis. Weight gene co-expression analysis revealed that integrin subunit β-like 1 (ITGBL1) was a key regulator of fibrogenesis. Functional experiments demonstrated that ITGBL1 was an upstream regulator of LF via interactions with transforming growth factor β1. In summary, we investigated the gene expression profiles of HBV-related LF patients and identified a key regulator ITGBL1. Our findings provide a foundation for future studies of gene functions and promote the development of novel antifibrotic therapies.

Original languageEnglish
Article number43446
Pages (from-to)1-13
Number of pages13
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 6 Mar 2017
Externally publishedYes

Fingerprint Dive into the research topics of 'Characterization of gene expression profiles in HBV-related liver fibrosis patients and identification of ITGBL1 as a key regulator of fibrogenesis'. Together they form a unique fingerprint.

Cite this