Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system

K. Belov, C.E. Sanderson, J.E. Deakin, E.S.W. Wong, D. Assange, K.A. McColl, A. Gout, B. De Bono, A.D. Barrow, T.P. Speed, J. Trowsdale, A.T. Papenfuss

    Research output: Contribution to journalArticle

    79 Citations (Scopus)

    Abstract

    The availability of the first marsupial genome sequence has allowed us to characterize the immunome of the gray short-tailed opossum (Monodelphis domestica). Here we report the identification of key immune genes, including the highly divergent chemokines, defensins, cathelicidins, and Natural Killer cell receptors. It appears that the increase in complexity of the mammalian immune system occurred prior to the divergence of the marsupial and eutherian lineages ∼180 million years ago. Genomes of ancestral mammals most likely contained all of the key mammalian immune gene families, with evolution on different continents, in the presence of different pathogens leading to lineage specific expansions and contractions, resulting in some minor differences in gene number and composition between different mammalian lineages. Gene expansion and extensive heterogeneity in opossum antimicrobial peptide genes may have evolved as a consequence of the newborn young needing to survive without an adaptive immune system in a pathogen laden environment. Given the similarities in the genomic architecture of the marsupial and eutherian immune systems, we propose that marsupials are ideal model organisms for the study of developmental immunology. ©2007 by Cold Spring Harbor Laboratory Press.
    Original languageUndefined
    Pages (from-to)982-991
    Number of pages10
    JournalGenome Research
    Volume17
    Issue number7
    DOIs
    Publication statusPublished - 2007

    Cite this

    Belov, K., Sanderson, C. E., Deakin, J. E., Wong, E. S. W., Assange, D., McColl, K. A., ... Papenfuss, A. T. (2007). Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system. Genome Research, 17(7), 982-991. https://doi.org/10.1101/gr.6121807
    Belov, K. ; Sanderson, C.E. ; Deakin, J.E. ; Wong, E.S.W. ; Assange, D. ; McColl, K.A. ; Gout, A. ; De Bono, B. ; Barrow, A.D. ; Speed, T.P. ; Trowsdale, J. ; Papenfuss, A.T. / Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system. In: Genome Research. 2007 ; Vol. 17, No. 7. pp. 982-991.
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    abstract = "The availability of the first marsupial genome sequence has allowed us to characterize the immunome of the gray short-tailed opossum (Monodelphis domestica). Here we report the identification of key immune genes, including the highly divergent chemokines, defensins, cathelicidins, and Natural Killer cell receptors. It appears that the increase in complexity of the mammalian immune system occurred prior to the divergence of the marsupial and eutherian lineages ∼180 million years ago. Genomes of ancestral mammals most likely contained all of the key mammalian immune gene families, with evolution on different continents, in the presence of different pathogens leading to lineage specific expansions and contractions, resulting in some minor differences in gene number and composition between different mammalian lineages. Gene expansion and extensive heterogeneity in opossum antimicrobial peptide genes may have evolved as a consequence of the newborn young needing to survive without an adaptive immune system in a pathogen laden environment. Given the similarities in the genomic architecture of the marsupial and eutherian immune systems, we propose that marsupials are ideal model organisms for the study of developmental immunology. {\circledC}2007 by Cold Spring Harbor Laboratory Press.",
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    Belov, K, Sanderson, CE, Deakin, JE, Wong, ESW, Assange, D, McColl, KA, Gout, A, De Bono, B, Barrow, AD, Speed, TP, Trowsdale, J & Papenfuss, AT 2007, 'Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system', Genome Research, vol. 17, no. 7, pp. 982-991. https://doi.org/10.1101/gr.6121807

    Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system. / Belov, K.; Sanderson, C.E.; Deakin, J.E.; Wong, E.S.W.; Assange, D.; McColl, K.A.; Gout, A.; De Bono, B.; Barrow, A.D.; Speed, T.P.; Trowsdale, J.; Papenfuss, A.T.

    In: Genome Research, Vol. 17, No. 7, 2007, p. 982-991.

    Research output: Contribution to journalArticle

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    AU - Sanderson, C.E.

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    AU - Wong, E.S.W.

    AU - Assange, D.

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