Chemokines and viruses: friends or foes?

Surendran Mahalingam, Jon Friedland, Mark Heise, Nestr Rulli, Jayesh Meanger, Brett Lidbury

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract

    The chemokine-mediated movement of leukocytes from peripheral blood into tissues is essential for immunity in higher organisms. In addition, chemokines play crucial roles in controlling the development and functional aspects of leukocytes, and it is now apparent that their role is not only restricted to cell attraction. Recent in vitro and in vivo findings support the contribution of the chemokine system in the resolution of viral infections. However, the chemokine response to other viral infections can be detrimental to the host because of aberrant cellular activity. This review aims to provide insights into both sides of the chemokine spectrum, and will touch on aspects of chemokine mimicry by RNA viruses and the possible implication for disease outcome.
    Original languageEnglish
    Pages (from-to)383-391
    Number of pages9
    JournalTrends in Microbiology
    Volume11
    Issue number8
    DOIs
    Publication statusPublished - 2003

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