Chirasil-β-Dex with a new C11-spacer for enantioselective gas chromatography. Application to the kinetic resolution of secondary alcohols catalyzed by lipase

A. Ghanem, C. Ginatta, Z. J. Jiang, V. Schurig

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was synthesized and used as a chiral stationary phase (CSP) in enantioselective GC. The versatility of the new CSP for the simultaneous enantiomeric separation of underivatized secondary alcohols and their corresponding acetates is demonstrated. The determination of enantiomeric excesses, ee, of substrate and product resulting from the lipase-catalyzed transesterification of secondary alcohols with isopropenylacetate in toluene was investigated using the title CSP.

Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalChromatographia
Volume57
Issue numberSUPPL.
DOIs
Publication statusPublished - 3 Jun 2003
Externally publishedYes

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Lipase
Gas chromatography
Gas Chromatography
Alcohols
Kinetics
Transesterification
Toluene
Acetates
Substrates
Chirasil-Dex

Cite this

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abstract = "Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was synthesized and used as a chiral stationary phase (CSP) in enantioselective GC. The versatility of the new CSP for the simultaneous enantiomeric separation of underivatized secondary alcohols and their corresponding acetates is demonstrated. The determination of enantiomeric excesses, ee, of substrate and product resulting from the lipase-catalyzed transesterification of secondary alcohols with isopropenylacetate in toluene was investigated using the title CSP.",
keywords = "C11-Chirasil-β-Dex stationary phase, Enantiomeric separations, Enzymatic kinetic resolution, Gas chromatography, Secondary alcohols",
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Chirasil-β-Dex with a new C11-spacer for enantioselective gas chromatography. Application to the kinetic resolution of secondary alcohols catalyzed by lipase. / Ghanem, A.; Ginatta, C.; Jiang, Z. J.; Schurig, V.

In: Chromatographia, Vol. 57, No. SUPPL., 03.06.2003, p. 275-281.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Chirasil-β-Dex with a new C11-spacer for enantioselective gas chromatography. Application to the kinetic resolution of secondary alcohols catalyzed by lipase

AU - Ghanem, A.

AU - Ginatta, C.

AU - Jiang, Z. J.

AU - Schurig, V.

PY - 2003/6/3

Y1 - 2003/6/3

N2 - Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was synthesized and used as a chiral stationary phase (CSP) in enantioselective GC. The versatility of the new CSP for the simultaneous enantiomeric separation of underivatized secondary alcohols and their corresponding acetates is demonstrated. The determination of enantiomeric excesses, ee, of substrate and product resulting from the lipase-catalyzed transesterification of secondary alcohols with isopropenylacetate in toluene was investigated using the title CSP.

AB - Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was synthesized and used as a chiral stationary phase (CSP) in enantioselective GC. The versatility of the new CSP for the simultaneous enantiomeric separation of underivatized secondary alcohols and their corresponding acetates is demonstrated. The determination of enantiomeric excesses, ee, of substrate and product resulting from the lipase-catalyzed transesterification of secondary alcohols with isopropenylacetate in toluene was investigated using the title CSP.

KW - C11-Chirasil-β-Dex stationary phase

KW - Enantiomeric separations

KW - Enzymatic kinetic resolution

KW - Gas chromatography

KW - Secondary alcohols

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JF - Chromatographia

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