Chirasil-β-Dex with a new C11-spacer for enantioselective gas chromatography. Application to the kinetic resolution of secondary alcohols catalyzed by lipase

A. Ghanem; C. Ginatta; Z. J. Jiang; V. Schurig

doi:10.1007/BF02492116

Chirasil-β-Dex with a new C11-spacer for enantioselective gas chromatography. Application to the kinetic resolution of secondary alcohols catalyzed by lipase

A. Ghanem, C. Ginatta, Z. J. Jiang, V. Schurig

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was synthesized and used as a chiral stationary phase (CSP) in enantioselective GC. The versatility of the new CSP for the simultaneous enantiomeric separation of underivatized secondary alcohols and their corresponding acetates is demonstrated. The determination of enantiomeric excesses, ee, of substrate and product resulting from the lipase-catalyzed transesterification of secondary alcohols with isopropenylacetate in toluene was investigated using the title CSP.

Original language	English
Pages (from-to)	275-281
Number of pages	7
Journal	Chromatographia
Volume	57
Issue number	SUPPL.
DOIs	https://doi.org/10.1007/BF02492116
Publication status	Published - 3 Jun 2003
Externally published	Yes

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10.1007/BF02492116

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title = "Chirasil-β-Dex with a new C11-spacer for enantioselective gas chromatography. Application to the kinetic resolution of secondary alcohols catalyzed by lipase",

abstract = "Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was synthesized and used as a chiral stationary phase (CSP) in enantioselective GC. The versatility of the new CSP for the simultaneous enantiomeric separation of underivatized secondary alcohols and their corresponding acetates is demonstrated. The determination of enantiomeric excesses, ee, of substrate and product resulting from the lipase-catalyzed transesterification of secondary alcohols with isopropenylacetate in toluene was investigated using the title CSP.",

keywords = "C11-Chirasil-β-Dex stationary phase, Enantiomeric separations, Enzymatic kinetic resolution, Gas chromatography, Secondary alcohols",

author = "A. Ghanem and C. Ginatta and Jiang, {Z. J.} and V. Schurig",

year = "2003",

month = jun,

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doi = "10.1007/BF02492116",

language = "English",

volume = "57",

pages = "275--281",

journal = "Chromatographia",

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TY - JOUR

T1 - Chirasil-β-Dex with a new C11-spacer for enantioselective gas chromatography. Application to the kinetic resolution of secondary alcohols catalyzed by lipase

AU - Ghanem, A.

AU - Ginatta, C.

AU - Jiang, Z. J.

AU - Schurig, V.

PY - 2003/6/3

Y1 - 2003/6/3

N2 - Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was synthesized and used as a chiral stationary phase (CSP) in enantioselective GC. The versatility of the new CSP for the simultaneous enantiomeric separation of underivatized secondary alcohols and their corresponding acetates is demonstrated. The determination of enantiomeric excesses, ee, of substrate and product resulting from the lipase-catalyzed transesterification of secondary alcohols with isopropenylacetate in toluene was investigated using the title CSP.

AB - Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was synthesized and used as a chiral stationary phase (CSP) in enantioselective GC. The versatility of the new CSP for the simultaneous enantiomeric separation of underivatized secondary alcohols and their corresponding acetates is demonstrated. The determination of enantiomeric excesses, ee, of substrate and product resulting from the lipase-catalyzed transesterification of secondary alcohols with isopropenylacetate in toluene was investigated using the title CSP.

KW - C11-Chirasil-β-Dex stationary phase

KW - Enantiomeric separations

KW - Enzymatic kinetic resolution

KW - Gas chromatography

KW - Secondary alcohols

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U2 - 10.1007/BF02492116

DO - 10.1007/BF02492116

M3 - Article

AN - SCOPUS:0038294457

SN - 0009-5893

VL - 57

SP - 275

EP - 281

JO - Chromatographia

JF - Chromatographia

IS - SUPPL.

ER -

Chirasil-β-Dex with a new C11-spacer for enantioselective gas chromatography. Application to the kinetic resolution of secondary alcohols catalyzed by lipase

Abstract

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