Coated protein nanoclusters from influenza H7N9 HA are highly immunogenic and induce robust protective immunity

Li Wang, Timothy Z. Chang, Yuan He, Jong R. Kim, Shelly Wang, Teena Mohan, Zachary Berman, S. Mark Tompkins, Ralph A. Tripp, Richard W. Compans, Julie A. Champion, Bao Zhong Wang

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Recurring influenza viruses pose an annual threat to public health. A time-saving, cost-effective and egg-independent influenza vaccine approach is important particularly when responding to an emerging pandemic. We fabricated coated, two-layer protein nanoclusters from recombinant trimeric hemagglutinin from an avian-origin H7N9 influenza A virus as an approach for vaccine development in response to an emerging pandemic. Assessment of the virus-specific immune responses and protective efficacy in mice immunized with the nanoclusters demonstrated that the vaccine candidates were highly immunogenic, able to induce protective immunity and long-lasting humoral antibody responses to this virus without the use of adjuvants. Because the advantages of the highly immunogenic coated nanoclusters also include rapid productions in an egg-independent system, this approach has great potential for influenza vaccine production not only in response to an emerging pandemic, but also as a replacement for conventional seasonal influenza vaccines.

Original languageEnglish
Pages (from-to)253-262
Number of pages10
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume13
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

Fingerprint

Dive into the research topics of 'Coated protein nanoclusters from influenza H7N9 HA are highly immunogenic and induce robust protective immunity'. Together they form a unique fingerprint.

Cite this