TY - JOUR
T1 - Cocoa and chocolate, their clinical benefits
T2 - Insights in study design
AU - Mellor, Duane D.
AU - Georgousopoulou, Ekavi N.
AU - Naumovski, Nenad
PY - 2017
Y1 - 2017
N2 - Randomized controlled trials and meta-analyses have demonstrated the potential protective effect of cocoa and chocolate consumption with respect to cardiovascular disease (CVD) risk markers. Findings from experimental studies are in concordance with observational data, which include reduction in clinical disease (especially stroke) being associated with chocolate consumption. However, the effect size of any benefit, and the exact mechanism of action due to variability in reporting of dose and type potential bioactive compounds remains unclear. Thus, the present review aimed to analyse the published work where cocoa and chocolate have been assessed for their potential to protect against CVD and highlight the role of study design and type of product used in the variances of outcomes and how that might be used in formulating health advice.
AB - Randomized controlled trials and meta-analyses have demonstrated the potential protective effect of cocoa and chocolate consumption with respect to cardiovascular disease (CVD) risk markers. Findings from experimental studies are in concordance with observational data, which include reduction in clinical disease (especially stroke) being associated with chocolate consumption. However, the effect size of any benefit, and the exact mechanism of action due to variability in reporting of dose and type potential bioactive compounds remains unclear. Thus, the present review aimed to analyse the published work where cocoa and chocolate have been assessed for their potential to protect against CVD and highlight the role of study design and type of product used in the variances of outcomes and how that might be used in formulating health advice.
KW - Cardiovascular disease
KW - Chocolate
KW - Cocoa
KW - Review
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=85023632940&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/cocoa-chocolate-clinical-benefits-insights-study-design
U2 - 10.1079/PAVSNNR201712018
DO - 10.1079/PAVSNNR201712018
M3 - Review article
AN - SCOPUS:85023632940
SN - 1749-8848
VL - 12
SP - 1
EP - 7
JO - CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources
JF - CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources
ER -