Cognition in breast cancer survivors

A pilot study of interval and continuous exercise

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVES: The current study investigated the effects of two exercise interventions on cognitive function amongst breast cancer survivors.

DESIGN: Pilot randomised-controlled trial.

METHODS: Seventeen female cancer survivors (mean: 62.9±7.8years) were randomised into three groups: high-intensity interval training (HIIT, n=6); moderate-intensity continuous training (MOD, n=5); or wait-list control (CON, n=6). The HIIT and MOD groups exercised on a cycle ergometer 3days/week for 12-weeks. Primary outcomes were cognitive function assessments utilising CogState. Secondary outcomes were resting middle cerebral artery blood flow velocity, cerebrovascular reactivity and aerobic fitness (VO2peak). Data were analysed with General Linear Mixed Models and Cohen's d effect sizes were calculated.

RESULTS: All 17 participants who were randomised were available for follow-up analysis and adherence was similar for HIIT and MOD (78.7±13.2% vs 79.4±12.0%; p=0.93). Although there were no significant differences in the cognitive and cerebrovascular outcomes, HIIT produced moderate to large positive effects in comparison to MOD and CON for outcomes including episodic memory, working memory, executive function, cerebral blood flow and cerebrovascular reactivity. HIIT significantly increased VO2peak by 19.3% (d=1.28) and MOD had a non-significant 5.6% (d=0.72) increase, compared to CON which had a 2.6% decrease.

CONCLUSIONS: This study provides preliminary evidence that HIIT may be an effective exercise intervention to improve cognitive performance, cerebrovascular function and aerobic fitness in breast cancer survivors. Considering the sample size is small, these results should be confirmed through larger clinical trials.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalJournal of Science and Medicine in Sport
DOIs
Publication statusE-pub ahead of print - 6 Dec 2018

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Cerebrovascular Circulation
Cognition
Breast Neoplasms
Episodic Memory
Blood Flow Velocity
Executive Function
Middle Cerebral Artery
Short-Term Memory
Sample Size
Linear Models
Randomized Controlled Trials
Clinical Trials
Neoplasms

Cite this

@article{3eed9a003e37453eb81c5893f8f9291c,
title = "Cognition in breast cancer survivors: A pilot study of interval and continuous exercise",
abstract = "OBJECTIVES: The current study investigated the effects of two exercise interventions on cognitive function amongst breast cancer survivors.DESIGN: Pilot randomised-controlled trial.METHODS: Seventeen female cancer survivors (mean: 62.9±7.8years) were randomised into three groups: high-intensity interval training (HIIT, n=6); moderate-intensity continuous training (MOD, n=5); or wait-list control (CON, n=6). The HIIT and MOD groups exercised on a cycle ergometer 3days/week for 12-weeks. Primary outcomes were cognitive function assessments utilising CogState. Secondary outcomes were resting middle cerebral artery blood flow velocity, cerebrovascular reactivity and aerobic fitness (VO2peak). Data were analysed with General Linear Mixed Models and Cohen's d effect sizes were calculated.RESULTS: All 17 participants who were randomised were available for follow-up analysis and adherence was similar for HIIT and MOD (78.7±13.2{\%} vs 79.4±12.0{\%}; p=0.93). Although there were no significant differences in the cognitive and cerebrovascular outcomes, HIIT produced moderate to large positive effects in comparison to MOD and CON for outcomes including episodic memory, working memory, executive function, cerebral blood flow and cerebrovascular reactivity. HIIT significantly increased VO2peak by 19.3{\%} (d=1.28) and MOD had a non-significant 5.6{\%} (d=0.72) increase, compared to CON which had a 2.6{\%} decrease.CONCLUSIONS: This study provides preliminary evidence that HIIT may be an effective exercise intervention to improve cognitive performance, cerebrovascular function and aerobic fitness in breast cancer survivors. Considering the sample size is small, these results should be confirmed through larger clinical trials.",
keywords = "High-intensity interval training, Cerebrovascular circulation, Cognitive function, Cardiorespiratory fitness",
author = "Northey, {Joseph M} and Pumpa, {Kate L} and Clare Quinlan and Ashley Ikin and Kellie Toohey and Smee, {Disa J} and Ben Rattray",
note = "Copyright {\circledC} 2018 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.",
year = "2018",
month = "12",
day = "6",
doi = "10.1016/j.jsams.2018.11.026",
language = "English",
pages = "1--6",
journal = "Australian Journal of Science and Medicine in Sport",
issn = "1440-2440",
publisher = "Elsevier",

}

TY - JOUR

T1 - Cognition in breast cancer survivors

T2 - A pilot study of interval and continuous exercise

AU - Northey, Joseph M

AU - Pumpa, Kate L

AU - Quinlan, Clare

AU - Ikin, Ashley

AU - Toohey, Kellie

AU - Smee, Disa J

AU - Rattray, Ben

N1 - Copyright © 2018 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

PY - 2018/12/6

Y1 - 2018/12/6

N2 - OBJECTIVES: The current study investigated the effects of two exercise interventions on cognitive function amongst breast cancer survivors.DESIGN: Pilot randomised-controlled trial.METHODS: Seventeen female cancer survivors (mean: 62.9±7.8years) were randomised into three groups: high-intensity interval training (HIIT, n=6); moderate-intensity continuous training (MOD, n=5); or wait-list control (CON, n=6). The HIIT and MOD groups exercised on a cycle ergometer 3days/week for 12-weeks. Primary outcomes were cognitive function assessments utilising CogState. Secondary outcomes were resting middle cerebral artery blood flow velocity, cerebrovascular reactivity and aerobic fitness (VO2peak). Data were analysed with General Linear Mixed Models and Cohen's d effect sizes were calculated.RESULTS: All 17 participants who were randomised were available for follow-up analysis and adherence was similar for HIIT and MOD (78.7±13.2% vs 79.4±12.0%; p=0.93). Although there were no significant differences in the cognitive and cerebrovascular outcomes, HIIT produced moderate to large positive effects in comparison to MOD and CON for outcomes including episodic memory, working memory, executive function, cerebral blood flow and cerebrovascular reactivity. HIIT significantly increased VO2peak by 19.3% (d=1.28) and MOD had a non-significant 5.6% (d=0.72) increase, compared to CON which had a 2.6% decrease.CONCLUSIONS: This study provides preliminary evidence that HIIT may be an effective exercise intervention to improve cognitive performance, cerebrovascular function and aerobic fitness in breast cancer survivors. Considering the sample size is small, these results should be confirmed through larger clinical trials.

AB - OBJECTIVES: The current study investigated the effects of two exercise interventions on cognitive function amongst breast cancer survivors.DESIGN: Pilot randomised-controlled trial.METHODS: Seventeen female cancer survivors (mean: 62.9±7.8years) were randomised into three groups: high-intensity interval training (HIIT, n=6); moderate-intensity continuous training (MOD, n=5); or wait-list control (CON, n=6). The HIIT and MOD groups exercised on a cycle ergometer 3days/week for 12-weeks. Primary outcomes were cognitive function assessments utilising CogState. Secondary outcomes were resting middle cerebral artery blood flow velocity, cerebrovascular reactivity and aerobic fitness (VO2peak). Data were analysed with General Linear Mixed Models and Cohen's d effect sizes were calculated.RESULTS: All 17 participants who were randomised were available for follow-up analysis and adherence was similar for HIIT and MOD (78.7±13.2% vs 79.4±12.0%; p=0.93). Although there were no significant differences in the cognitive and cerebrovascular outcomes, HIIT produced moderate to large positive effects in comparison to MOD and CON for outcomes including episodic memory, working memory, executive function, cerebral blood flow and cerebrovascular reactivity. HIIT significantly increased VO2peak by 19.3% (d=1.28) and MOD had a non-significant 5.6% (d=0.72) increase, compared to CON which had a 2.6% decrease.CONCLUSIONS: This study provides preliminary evidence that HIIT may be an effective exercise intervention to improve cognitive performance, cerebrovascular function and aerobic fitness in breast cancer survivors. Considering the sample size is small, these results should be confirmed through larger clinical trials.

KW - High-intensity interval training

KW - Cerebrovascular circulation

KW - Cognitive function

KW - Cardiorespiratory fitness

U2 - 10.1016/j.jsams.2018.11.026

DO - 10.1016/j.jsams.2018.11.026

M3 - Article

SP - 1

EP - 6

JO - Australian Journal of Science and Medicine in Sport

JF - Australian Journal of Science and Medicine in Sport

SN - 1440-2440

ER -