TY - JOUR
T1 - Cognition in breast cancer survivors
T2 - A pilot study of interval and continuous exercise
AU - Northey, Joseph M
AU - Pumpa, Kate L
AU - Quinlan, Clare
AU - Ikin, Ashley
AU - Toohey, Kellie
AU - Smee, Disa J
AU - Rattray, Ben
N1 - Publisher Copyright:
© 2018 Sports Medicine Australia
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/5
Y1 - 2019/5
N2 - OBJECTIVES: The current study investigated the effects of two exercise interventions on cognitive function amongst breast cancer survivors.DESIGN: Pilot randomised-controlled trial.METHODS: Seventeen female cancer survivors (mean: 62.9±7.8years) were randomised into three groups: high-intensity interval training (HIIT, n=6); moderate-intensity continuous training (MOD, n=5); or wait-list control (CON, n=6). The HIIT and MOD groups exercised on a cycle ergometer 3days/week for 12-weeks. Primary outcomes were cognitive function assessments utilising CogState. Secondary outcomes were resting middle cerebral artery blood flow velocity, cerebrovascular reactivity and aerobic fitness (VO2peak). Data were analysed with General Linear Mixed Models and Cohen's d effect sizes were calculated.RESULTS: All 17 participants who were randomised were available for follow-up analysis and adherence was similar for HIIT and MOD (78.7±13.2% vs 79.4±12.0%; p=0.93). Although there were no significant differences in the cognitive and cerebrovascular outcomes, HIIT produced moderate to large positive effects in comparison to MOD and CON for outcomes including episodic memory, working memory, executive function, cerebral blood flow and cerebrovascular reactivity. HIIT significantly increased VO2peak by 19.3% (d=1.28) and MOD had a non-significant 5.6% (d=0.72) increase, compared to CON which had a 2.6% decrease.CONCLUSIONS: This study provides preliminary evidence that HIIT may be an effective exercise intervention to improve cognitive performance, cerebrovascular function and aerobic fitness in breast cancer survivors. Considering the sample size is small, these results should be confirmed through larger clinical trials.
AB - OBJECTIVES: The current study investigated the effects of two exercise interventions on cognitive function amongst breast cancer survivors.DESIGN: Pilot randomised-controlled trial.METHODS: Seventeen female cancer survivors (mean: 62.9±7.8years) were randomised into three groups: high-intensity interval training (HIIT, n=6); moderate-intensity continuous training (MOD, n=5); or wait-list control (CON, n=6). The HIIT and MOD groups exercised on a cycle ergometer 3days/week for 12-weeks. Primary outcomes were cognitive function assessments utilising CogState. Secondary outcomes were resting middle cerebral artery blood flow velocity, cerebrovascular reactivity and aerobic fitness (VO2peak). Data were analysed with General Linear Mixed Models and Cohen's d effect sizes were calculated.RESULTS: All 17 participants who were randomised were available for follow-up analysis and adherence was similar for HIIT and MOD (78.7±13.2% vs 79.4±12.0%; p=0.93). Although there were no significant differences in the cognitive and cerebrovascular outcomes, HIIT produced moderate to large positive effects in comparison to MOD and CON for outcomes including episodic memory, working memory, executive function, cerebral blood flow and cerebrovascular reactivity. HIIT significantly increased VO2peak by 19.3% (d=1.28) and MOD had a non-significant 5.6% (d=0.72) increase, compared to CON which had a 2.6% decrease.CONCLUSIONS: This study provides preliminary evidence that HIIT may be an effective exercise intervention to improve cognitive performance, cerebrovascular function and aerobic fitness in breast cancer survivors. Considering the sample size is small, these results should be confirmed through larger clinical trials.
KW - High-intensity interval training
KW - Cerebrovascular circulation
KW - Cognitive function
KW - Cardiorespiratory fitness
UR - http://www.scopus.com/inward/record.url?scp=85058233396&partnerID=8YFLogxK
U2 - 10.1016/j.jsams.2018.11.026
DO - 10.1016/j.jsams.2018.11.026
M3 - Article
C2 - 30554923
SN - 1440-2440
VL - 22
SP - 580
EP - 585
JO - Journal of Science and Medicine in Sport
JF - Journal of Science and Medicine in Sport
IS - 5
ER -