TY - JOUR
T1 - Cognitive/functional measures predict alzheimer's disease, dependent on hippocampal volume
AU - Tabatabaei-Jafari, Hossein
AU - Shaw, Marnie E.
AU - Walsh, Erin
AU - Cherbuin, Nicolas
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2019/1/21
Y1 - 2019/1/21
N2 - Objectives: This study aimed to investigate the predictive value of cognitive/functional measures in combination with hippocampal volume (HCV) on the probability of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Methods: The Rey Auditory Verbal Learning Test for immediate memory, Mini-Mental State Examination, a functional assessment for independent daily activities and Alzheimer's Disease Assessment Scale were used as cognitive/functional measures and HCV as neuroimaging measure. Logistic regression and Cox proportional hazard analyses were used to explore the measures' predictive values for AD conversion and time to conversion. Results: The probability of conversion from MCI to AD was associated with cognitive function, but this was moderated by HCV: Higher at lower HCV and lower at higher HCV. General cognitive/functional measures were less predictive than immediate memory in predicting time to conversion to AD at small HCVs. Conclusion: Effectiveness of cognitive measures and subtle functional abnormality in predicting conversion from MCI to AD is dependent on HCV, thus combined evaluation should be considered. A combination of HCV and immediate memory appear to perform best in predicting time to conversion.
AB - Objectives: This study aimed to investigate the predictive value of cognitive/functional measures in combination with hippocampal volume (HCV) on the probability of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD). Methods: The Rey Auditory Verbal Learning Test for immediate memory, Mini-Mental State Examination, a functional assessment for independent daily activities and Alzheimer's Disease Assessment Scale were used as cognitive/functional measures and HCV as neuroimaging measure. Logistic regression and Cox proportional hazard analyses were used to explore the measures' predictive values for AD conversion and time to conversion. Results: The probability of conversion from MCI to AD was associated with cognitive function, but this was moderated by HCV: Higher at lower HCV and lower at higher HCV. General cognitive/functional measures were less predictive than immediate memory in predicting time to conversion to AD at small HCVs. Conclusion: Effectiveness of cognitive measures and subtle functional abnormality in predicting conversion from MCI to AD is dependent on HCV, thus combined evaluation should be considered. A combination of HCV and immediate memory appear to perform best in predicting time to conversion.
KW - Brain/cognitive reserve
KW - Hippocampus
KW - Mild cognitive impairment
KW - MRI
KW - Neuropsychological tests
UR - http://www.scopus.com/inward/record.url?scp=85072838355&partnerID=8YFLogxK
U2 - 10.1093/geronb/gbz011
DO - 10.1093/geronb/gbz011
M3 - Article
C2 - 30668830
AN - SCOPUS:85072838355
SN - 1079-5014
VL - 75
SP - 1393
EP - 1402
JO - Journals of Gerontology - Series B Psychological Sciences and Social Sciences
JF - Journals of Gerontology - Series B Psychological Sciences and Social Sciences
IS - 7
ER -